INT10844

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Context Info
Confidence 0.13
First Reported 1990
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 4.77
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh) extracellular region (Ghrh, Gh) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 1
Ghrh (Rattus norvegicus)
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 41 99.84 Very High Very High Very High
Somatostatin 8 99.80 Very High Very High Very High
Sumatriptan 11 99.58 Very High Very High Very High
agonist 5 93.92 High High
Opioid 4 82.96 Quite High
opiate 2 74.88 Quite High
antagonist 3 74.32 Quite High
tolerance 1 56.40 Quite High
Neurotransmitter 1 52.08 Quite High
Endogenous opioid 2 48.40 Quite Low
Disease Link Frequency Relevance Heat
Cushing's Syndrome /

Hypercortisolism

5 99.54 Very High Very High Very High
Obesity 42 99.34 Very High Very High Very High
Depression 2 96.84 Very High Very High Very High
Polycystic Ovary Syndrome 8 96.16 Very High Very High Very High
Alcohol Addiction 1 93.24 High High
Anxiety Disorder 1 91.48 High High
Obsessive-compulsive Disorder 1 91.28 High High
Hypoglycemia 2 87.80 High High
Syndrome 6 86.04 High High
Disease 3 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present.
GHRH Regulation (values) of GH
1) Confidence 0.13 Published 1997 Journal Psychiatry Res Section Abstract Doc Link 9109183 Disease Relevance 0.18 Pain Relevance 0.26
Unexpectedly, we found that five of the 21 (26%) normal controls had no GH secretory response to either GRF or clonidine.
GRF Neg (no) Regulation (response) of GH associated with clonidine
2) Confidence 0.12 Published 1990 Journal Psychoneuroendocrinology Section Abstract Doc Link 2087535 Disease Relevance 0 Pain Relevance 1.06
Basal GH and SmC levels, and GH response to GHRH did not differ in patients and controls, whereas responses to clonidine were significantly higher in some and lower in other patients than in controls.
GHRH Regulation (response) of GH associated with clonidine
3) Confidence 0.10 Published 1994 Journal Biol. Psychiatry Section Abstract Doc Link 8080904 Disease Relevance 0.17 Pain Relevance 0.26
Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase?
GHRH Regulation (response) of Growth hormone associated with obesity, somatostatin and clonidine
4) Confidence 0.09 Published 1995 Journal Eur. J. Endocrinol. Section Title Doc Link 7788012 Disease Relevance 0.50 Pain Relevance 0.30
Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase?
hormone-releasing hormone Regulation (response) of Growth hormone associated with obesity, somatostatin and clonidine
5) Confidence 0.08 Published 1995 Journal Eur. J. Endocrinol. Section Title Doc Link 7788012 Disease Relevance 0.50 Pain Relevance 0.30
In normals, SU is able to decrease GH response to GHRH, thus confirming that 5-HT1D receptors are able to modulate GH secretion in normals.
GHRH Regulation (response) of GH associated with sumatriptan
6) Confidence 0.06 Published 1997 Journal Recenti Prog Med Section Abstract Doc Link 9233053 Disease Relevance 0.07 Pain Relevance 0.69
These data are compatible with the hypothesis that beta-endorphin levels affect the GH response to GHRH in prepubertal children, but have no discernible effect on the GH response to GHRH in pubertal children.
GHRH Regulation (response) of GH
7) Confidence 0.06 Published 1992 Journal Endocr. Res. Section Abstract Doc Link 1576976 Disease Relevance 0.05 Pain Relevance 0
The GH is regulated by the influence of GRF and somatostatin that respectively are under the adrenergic and cholinergic control, for this reason we studied how and in which measure a cholinergic agonist (pyridostigmine) acts on GH release during the clonidine and GRF stimulation tests.
GRF Regulation (regulated) of GH associated with agonist, somatostatin and clonidine
8) Confidence 0.06 Published 1991 Journal Minerva Pediatr. Section Abstract Doc Link 1758382 Disease Relevance 0 Pain Relevance 0.61
This is mainly due to the impaired GH secretion observed during hypercortisolism, a situation in which GH responses to a number of stimuli, including GHRH, are blunted.
GHRH Regulation (responses) of GH
9) Confidence 0.05 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.04
Dividing the patients into two groups according to age-of-onset (less than 60 years greater than), there was a trend toward larger GH responses to GHRH for the early-onset group.
GHRH Regulation (responses) of GH
10) Confidence 0.02 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522942 Disease Relevance 0.15 Pain Relevance 0.28
NTX treatment reduced fasting insulin levels in patients with EO (P < .05) and restored a normal GH response to GHRH without affecting IGF-1 and IGFBP-3 levels.
GHRH Regulation (response) of GH associated with obesity
11) Confidence 0.02 Published 1997 Journal Metab. Clin. Exp. Section Abstract Doc Link 9160821 Disease Relevance 1.60 Pain Relevance 0.55
The GH responses to GHRH+ARG and GHRH+PD in NC were similar and higher than that to CLO (p<0.001).
GHRH Regulation (responses) of GH
12) Confidence 0.01 Published 2000 Journal J. Endocrinol. Invest. Section Abstract Doc Link 10800760 Disease Relevance 0.58 Pain Relevance 0.08
The GH responses to GHRH+ARG and GHRH+PD in NC were similar and higher than that to CLO (p<0.001).
GHRH Regulation (responses) of GH
13) Confidence 0.01 Published 2000 Journal J. Endocrinol. Invest. Section Abstract Doc Link 10800760 Disease Relevance 0.57 Pain Relevance 0.08
To evaluate pituitary responsiveness to direct stimulation with GHRH, we have studied the GH and PRL response to GHRH in 10 alcoholics during early abstinence.
GHRH Regulation (response) of GH in pituitary
14) Confidence 0.01 Published 1993 Journal Psychoneuroendocrinology Section Abstract Doc Link 8265735 Disease Relevance 0.18 Pain Relevance 0.21

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