INT108468

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
nucleus accumbens 3
striatum 2
frontal cortex 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 11 100.00 Very High Very High Very High
substance P 17 99.84 Very High Very High Very High
Nucleus accumbens 4 99.40 Very High Very High Very High
narcan 2 89.16 High High
Morphine 6 87.08 High High
withdrawal 10 86.64 High High
Opioid 6 85.24 High High
addiction 2 65.44 Quite High
Neuropeptide 4 50.00 Quite Low
Glutamate receptor 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 98.52 Very High Very High Very High
Substance Withdrawal Syndrome 2 86.64 High High
Opiate Addiction 2 69.92 Quite High
Schizophrenia 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that the level of the dopamine D2 receptor transcript was significantly reduced by SP(1-7) in nucleus accumbens and frontal cortex but not altered in the striatum.
Neg (not) Negative_regulation (reduced) of Gene_expression (level) of dopamine D2 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, urological neuroanatomy and substance p
1) Confidence 0.41 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.33 Pain Relevance 1.29
RESULTS: The main results are the postpubertal onset of increased NR1 mRNA expression in all cortical regions and decreased dopamine D2 receptor, substance P and enkephalin mRNA expression in the striatum only in rats lesioned as neonates.
Negative_regulation (decreased) of Gene_expression (expression) of dopamine D2 receptor in striatum
2) Confidence 0.39 Published 2009 Journal Schizophr. Res. Section Body Doc Link 19500946 Disease Relevance 0 Pain Relevance 0
The results indicated that the level of the dopamine D2 receptor transcript was significantly reduced by SP(1-7) in nucleus accumbens and frontal cortex but not altered in the striatum.
Neg (not) Negative_regulation (reduced) of in frontal cortex Gene_expression (level) of dopamine D2 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, urological neuroanatomy and substance p
3) Confidence 0.14 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.33 Pain Relevance 1.29

General Comments

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