INT10847

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 39
Total Number 47
Disease Relevance 27.00
Pain Relevance 12.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMC2) extracellular region (LAMC2) cell adhesion (LAMC2)
Anatomy Link Frequency
CSF 13
T cells 3
blood 2
bands 2
Plasma 1
LAMC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
substance P 12 99.96 Very High Very High Very High
anesthesia 6 99.82 Very High Very High Very High
Somatostatin 7 99.48 Very High Very High Very High
unmyelinated 1 99.48 Very High Very High Very High
Pain 20 99.44 Very High Very High Very High
electroacupuncture 8 99.32 Very High Very High Very High
Enkephalin 1 98.88 Very High Very High Very High
Migraine 14 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphocytosis 84 100.00 Very High Very High Very High
Closed Head Injuries 6 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 3 100.00 Very High Very High Very High
Lumbar Puncture Related Headaches 14 99.76 Very High Very High Very High
Obesity 8 99.68 Very High Very High Very High
Syndrome 54 99.60 Very High Very High Very High
Neurodegenerative Disease 1 99.56 Very High Very High Very High
Disease 114 99.46 Very High Very High Very High
Transverse Myelitis 28 99.38 Very High Very High Very High
Solid Tumor 2 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data from the one patient with Pick's disease demonstrates that reduced CSF levels of neurophysins and hormones is not confined to Alzheimer-type dementia.
Gene_expression (levels) of CSF in CSF associated with dementia and disease
1) Confidence 0.75 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.45 Pain Relevance 0.11
Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain.
Gene_expression (levels) of CSF in CSF associated with central sensitization, migraine, somatostatin and headache
2) Confidence 0.75 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.08 Pain Relevance 2.56
We infer that by enhancing the production of dynorphin in CSF, high-frequency EA decrease the excitability of the motor neurons in the anterior horns through the kappa opiate receptors, thus ameliorating the muscle spasticity of spinal origin.
Gene_expression (production) of CSF in motor neurons associated with spasticity, dynorphin, opiate and electroacupuncture
3) Confidence 0.75 Published 1993 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 8313180 Disease Relevance 0.25 Pain Relevance 0.59
Plasma and CSF levels of both the parent drug and its active metabolite were correlated.
Gene_expression (levels) of CSF in CSF
4) Confidence 0.75 Published 1989 Journal Acta Psychiatr Scand Section Abstract Doc Link 2475012 Disease Relevance 0.15 Pain Relevance 0.58
Blood and CSF levels of HIV viral load, monocyte chemotactic protein-1, macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-2, and tumor necrosis factor-alpha were measured in addition to CD4 lymphocyte cell count.
Gene_expression (levels) of CSF in lymphocyte
5) Confidence 0.75 Published 2005 Journal Neurology Section Body Doc Link 15753420 Disease Relevance 0.17 Pain Relevance 0
The objectives of this study were (1) to determine how cerebrospinal fluid (CSF) neurofilament heavy chain (NfH(SM134) and NfH(SM135)) levels relate to clinical outcome in optic neuritis (ON) and multiple sclerosis (MS) relapse patients treated with high dose oral methylprednisolone; and (2) to correlate neurofilament and myelin basic protein (MBP) concentrations, particularly as the latter was previously associated with clinical disability.
Gene_expression (levels) of CSF in cerebrospinal fluid associated with multiple sclerosis, optic neuritis, neuritis and recurrence
6) Confidence 0.65 Published 2005 Journal Mult. Scler. Section Abstract Doc Link 16193890 Disease Relevance 0.75 Pain Relevance 0.46
the host spinal CSF revealed only slight further
Gene_expression (revealed) of CSF in spinal
7) Confidence 0.65 Published 1994 Journal Journal of Neural Transplantation & Plasticity Section Abstract Doc Link PMC2565279 Disease Relevance 0.19 Pain Relevance 0.78
Serum and CSF lack aquaporin-4-specific IgM, and plasma cells in CNS lesions of NMO contain only IgG.
Gene_expression (contain) of CSF in plasma cells
8) Confidence 0.65 Published 2007 Journal Neurology Section Body Doc Link 17928579 Disease Relevance 0 Pain Relevance 0
Lumbar puncture showed low CSF glucose, high CSF protein and no tumor cells.
Gene_expression (glucose) of CSF in puncture associated with cancer and lumbar puncture related headaches
9) Confidence 0.65 Published 2009 Journal Clin Neurol Neurosurg Section Abstract Doc Link 19128871 Disease Relevance 1.10 Pain Relevance 0.34
Temozolomide CSF levels are 10-20% of blood levels.
Gene_expression (levels) of CSF in blood
10) Confidence 0.65 Published 2009 Journal J. Neurooncol. Section Abstract Doc Link 19322519 Disease Relevance 0.49 Pain Relevance 0.07
Patients were diagnosed by India ink(100%), CSF cryptococcal antigen detection(100%), and CSF culture in 6(85.7%).
Gene_expression (detection) of CSF in CSF
11) Confidence 0.65 Published 2009 Journal Nippon Ishinkin Gakkai Zasshi Section Abstract Doc Link 19430184 Disease Relevance 0.70 Pain Relevance 0.09
Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS
Gene_expression (levels) of CSF associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.65 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1187874 Disease Relevance 0.20 Pain Relevance 0.04
Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients.
Neg (negative) Gene_expression (levels) of CSF in CSF associated with neuromyelitis optica and disease
13) Confidence 0.65 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20128675 Disease Relevance 1.14 Pain Relevance 0.13
NMO and transverse myelitis patients had higher serum and CSF IL-6 levels than other groups.
Gene_expression (levels) of CSF in CSF associated with neuromyelitis optica and transverse myelitis
14) Confidence 0.65 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20128675 Disease Relevance 1.17 Pain Relevance 0.14
Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients.
Gene_expression (levels) of CSF in CSF associated with neuromyelitis optica and disease
15) Confidence 0.65 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20128675 Disease Relevance 1.16 Pain Relevance 0.14
When correctly performed under local anesthesia, lumbar CSF collection in ruminants is a safe procedure and there are no harmful sequelae.
Gene_expression (collection) of CSF in CSF associated with anesthesia
16) Confidence 0.65 Published 2004 Journal Vet. Clin. North Am. Food Anim. Pract. Section Abstract Doc Link 15203223 Disease Relevance 0.44 Pain Relevance 0.28
Significantly elevated levels of IL-18 were detected at 7 days after CHI and in human CSF up to 10 days after trauma.
Gene_expression (detected) of CSF associated with injury and closed head injuries
17) Confidence 0.65 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 12172382 Disease Relevance 1.14 Pain Relevance 0.18
The term CSF hypovolemia is proposed for this syndrome because the term intracranial hypotension no longer seems adequate to embrace all the variations that have emerged.
Neg (no) Gene_expression (proposed) of CSF in CSF associated with intracranial hypotension, pressure volume 2 under development and syndrome
18) Confidence 0.65 Published 1999 Journal Mayo Clin. Proc. Section Abstract Doc Link 10560599 Disease Relevance 1.22 Pain Relevance 0.60
The percentage of cases with at least one altered CSF IgG parameter (IgG index, IgG synthesis/day and IgG oligoclonal bands) has been higher than that of cases with one or more altered neurophysiological tests, regardless of the apparently intact eye VEP.
Gene_expression (synthesis/day) of CSF in eye
19) Confidence 0.65 Published 1987 Journal Acta Neurol. Scand. Section Abstract Doc Link 3577677 Disease Relevance 0.44 Pain Relevance 0.50
In addition, we have carried out a large-scale expression and purification of recombinant hGM-CSF in B. mori pupae and developed a new approach to the oral administration of these recombinant proteins [20].
Gene_expression (expression) of CSF
20) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592543 Disease Relevance 0.28 Pain Relevance 0

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