INT108479

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 19.93
Pain Relevance 10.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
microglial cells 2
skin 2
lymph nodes 1
blood 1
B cells 1
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 573 100.00 Very High Very High Very High
Multiple sclerosis 20 99.84 Very High Very High Very High
Dorsal horn neuron 5 99.84 Very High Very High Very High
spinothalamic tract 5 99.82 Very High Very High Very High
Thalamus 15 99.68 Very High Very High Very High
endometriosis 420 99.60 Very High Very High Very High
intrathecal 4 99.50 Very High Very High Very High
Neuritis 12 99.36 Very High Very High Very High
Lasting pain 5 98.42 Very High Very High Very High
Central nervous system 9 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Demyelinating Disease 20 99.84 Very High Very High Very High
Sialadenitis 3 99.84 Very High Very High Very High
Frailty 36 99.80 Very High Very High Very High
Endometriosis 486 99.60 Very High Very High Very High
Leukemia 19 99.44 Very High Very High Very High
Neurological Disease 14 99.44 Very High Very High Very High
Optic Neuritis 12 99.36 Very High Very High Very High
Malignant Neoplastic Disease 8 98.64 Very High Very High Very High
Pain 26 98.42 Very High Very High Very High
Infection 202 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that CCL21 is upregulated in dorsal horn neurons, that tissue levels are increased in the dorsal horn and ventral posterolateral (VPL) nucleus of the thalamus 4 weeks after SCI, and that the increase can be differentially reduced by spinal blockade at T1 or L1.
Positive_regulation (upregulated) of CCL21 in neurons associated with frailty, dorsal horn, thalamus and dorsal horn neuron
1) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.85 Pain Relevance 0.75
In contrast, in women with endometriosis, eutopic CCL16 and CCL21 mRNA levels were increased in some subjects but with significant patient-to-patient variability.
Positive_regulation (increased) of CCL21 mRNA associated with endometriosis
2) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.59 Pain Relevance 0.33
How an elevation of CCL21 may contribute to endometriosis is not certain.
Positive_regulation (elevation) of CCL21 associated with endometriosis
3) Confidence 0.64 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.97 Pain Relevance 0.37
These data identify a novel pathway by which SCI triggers upregulation of the neuroimmune modulator CCL21 in the thalamus, which induces microglial activation in association with pain phenomena.
Positive_regulation (upregulation) of CCL21 in thalamus associated with pain, frailty and thalamus
4) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.82 Pain Relevance 0.68
Here, we examined whether microglial cells in the thalamus contribute to the modulation of chronic pain after SCI, and whether microglial activation is governed by spinally mediated increases in the microglial activator cysteine-cysteine chemokine ligand 21 (CCL21).
Spec (whether) Positive_regulation (increases) of cysteine-cysteine chemokine ligand 21 in microglial cells associated with chemokine, lasting pain, frailty and thalamus
5) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.86 Pain Relevance 0.76
Here, we examined whether microglial cells in the thalamus contribute to the modulation of chronic pain after SCI, and whether microglial activation is governed by spinally mediated increases in the microglial activator cysteine-cysteine chemokine ligand 21 (CCL21).
Spec (whether) Positive_regulation (increases) of CCL21 in microglial cells associated with chemokine, lasting pain, frailty and thalamus
6) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.86 Pain Relevance 0.76
In intact animals, electrical stimulation of the spinothalamic tract induces increases in thalamic CCL21 levels.
Positive_regulation (increases) of CCL21 associated with spinothalamic tract
7) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.90 Pain Relevance 0.83
Since the findings from the cDNA array and real time RT-PCR experiments supported a role for CCL21 and CCL16 in at least some women with endometriosis, immunohistochemistry was performed to establish the presence and cellular location of the protein for these 2 chemokines in eutopic and ectopic endometrial samples.
Positive_regulation (role) of CCL21 associated with chemokine and endometriosis
8) Confidence 0.46 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.66 Pain Relevance 0.47
This data thus adds CCL16 and CCL21 to the chemokines found to be elevated in endometriosis supporting a role for chemokines in the pathogenesis of endometriosis.
Positive_regulation (adds) of CCL21 associated with endometriosis and chemokine
9) Confidence 0.46 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.59 Pain Relevance 0.55
On the other hand, our group and others have demonstrated that up-regulation of CCL21 could also take place in dermal LEC from patients with other diseases.
Positive_regulation (regulation) of CCL21 associated with disease
10) Confidence 0.46 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.28 Pain Relevance 0.31
CCL16 and CCL21 mRNA was confirmed as elevated in some women with endometriosis compared to controls on individual samples.
Positive_regulation (elevated) of CCL21 mRNA associated with endometriosis
11) Confidence 0.43 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.64 Pain Relevance 0.52
CCL21 mRNA was more abundant than that of CCL16 and was markedly elevated in eutopic glands from one endometriosis patient (mean, 0.61 fg/pg 18S RNA) (Figure 2B).
Positive_regulation (elevated) of CCL21 mRNA in glands associated with endometriosis
12) Confidence 0.43 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.63 Pain Relevance 0.38
To block unspecific sites, tissue samples were incubated with Blocking solution (CSA, DAKO Corporation, USA) in PBS for 10 min, incubated for 1 hours with goat anti human CCL21 (SC-5808, Santa Cruz Biotechnologies) at 0.067 ?
Positive_regulation (incubated) of CCL21
13) Confidence 0.43 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0 Pain Relevance 0
Immunohistochemical studies showed up-regulation of CCL21 by lymphatic endothelial cells in all the biopsies taken from ICD and ACD lesions compared to normal skin.
Positive_regulation (up-regulation) of CCL21 in skin associated with allergic dermatitis and contact dermatitis
14) Confidence 0.40 Published 2004 Journal BMC Immunol Section Abstract Doc Link PMC419342 Disease Relevance 0.80 Pain Relevance 0.13
Based upon these results, we concluded that two different types of stress signals affecting the skin, antigen specific or non-specific immune responses are capable of inducing CCL21 up-regulation by LEC.
Positive_regulation (inducing) of CCL21 in skin associated with stress
15) Confidence 0.40 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.52 Pain Relevance 0.18
It is therefore unlikely that SF PMN favor the formation of ectopic germinal centers, in which increased levels of CCL21 were detected [45].
Positive_regulation (increased) of CCL21
16) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.36 Pain Relevance 0.51
We found that CCL19 but not CCL21 mRNA was increased 8-fold in lymph nodes at 12 weeks post infection, but only in animals that progressed to AIDS (Figure 4E).
Positive_regulation (increased) of CCL21 in lymph nodes associated with acquired immune deficiency syndrome or hiv infection and infection
17) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.91 Pain Relevance 0
Accordingly, CXCL13 and CCL21 transcript levels were significantly increased in LESA samples while CXCL12 levels were increased in MALT lymphoma and isolated tumor cells.
Positive_regulation (increased) of CCL21 transcript in MALT associated with lymphatic system cancer, cancer and sialadenitis
18) Confidence 0.22 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.92 Pain Relevance 0.15
Indeed, recent studies have shown that increased levels of CCL19 and CCL21 in blood correlate with higher virus loads and disease progression in HIV infected humans [30].
Positive_regulation (increased) of CCL21 in blood associated with acquired immune deficiency syndrome or hiv infection and disease progression
19) Confidence 0.22 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0.08
The role of elevated CCL19 and CCL21 in MS could be retention of mature dendritic cells (DC) in the CNS, recruitment of nai;ve T cells and activated B cells, as well as de novo formation of secondary lymphoid structures in MS plaques.
Positive_regulation (elevated) of CCL21 in B cells associated with multiple sclerosis and central nervous system
20) Confidence 0.20 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.33 Pain Relevance 1.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox