INT10848

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.76
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 10
stem 2
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 4 99.88 Very High Very High Very High
cytokine 16 99.68 Very High Very High Very High
Pain 9 99.60 Very High Very High Very High
anesthesia 9 99.54 Very High Very High Very High
antagonist 24 99.00 Very High Very High Very High
opiate 4 98.56 Very High Very High Very High
noradrenaline 53 98.04 Very High Very High Very High
rapifen 7 97.66 Very High Very High Very High
Endogenous opioid 3 95.60 Very High Very High Very High
Dopamine 8 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 7 100.00 Very High Very High Very High
Natriuresis 10 99.80 Very High Very High Very High
Pain 9 99.60 Very High Very High Very High
Vomiting 10 99.04 Very High Very High Very High
Hyponatremia 62 97.88 Very High Very High Very High
Hypothermia 55 97.20 Very High Very High Very High
Diuresis 20 94.74 High High
Sepsis 125 92.48 High High
Congenital Anomalies 1 90.68 High High
Hypotension 22 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At high concentrations it inhibits the production of vasopressin [50].
Negative_regulation (inhibits) of Gene_expression (production) of vasopressin
1) Confidence 0.59 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.66 Pain Relevance 0.48
While the differential diagnosis for hyponatremia is diverse, most cases stem from arginine vasopressin (AVP) dysregulation, where hypoosmolality fails to suppress AVP synthesis and release.
Negative_regulation (suppress) of Gene_expression (synthesis) of AVP in stem associated with hyponatremia
2) Confidence 0.54 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2504060 Disease Relevance 0.48 Pain Relevance 0
Naloxone both reduced resting levels of vasopressin and inhibited the rise in vasopressin induced by an orthostatic stimulus.
Negative_regulation (reduced) of Gene_expression (levels) of vasopressin associated with narcan
3) Confidence 0.43 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.51
The data demonstrate that alfentanil-O2 and sufentanil-O2 result in little change in cardiovascular dynamics throughout anesthesia and surgery, and also prevent changes in plasma levels of ADH and GH at all times during the study.
Negative_regulation (prevent) of Gene_expression (levels) of ADH in plasma associated with rapifen and anesthesia
4) Confidence 0.42 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 6461279 Disease Relevance 0.08 Pain Relevance 0.52
Vasopressin levels for these patients (3.6 +/- 0.4 fmol/ml) were also significantly reduced to 51% of controls (p less than 0.007) and oxytocin levels were marginally (p = 0.092) reduced to 70% of controls.
Negative_regulation (reduced) of Gene_expression (levels) of Vasopressin
5) Confidence 0.41 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.38 Pain Relevance 0.13
What should be the duration of AVP perfusion?
Negative_regulation (duration) of Gene_expression (perfusion) of AVP
6) Confidence 0.37 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.57 Pain Relevance 0.28
These results indicate that chronic inanition due to surreptitious vomiting causes impaired renal diluting ability through decreases in GFR and RPF, irrespective of the levels of plasma AVP and ANP.
Negative_regulation (decreases) of Gene_expression (levels) of plasma AVP in plasma associated with disorders of creatine metabolism and vomiting
7) Confidence 0.37 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.89 Pain Relevance 0.06
Dobutamine increased MAP (p = 0.009), CI (p < 0.001), HR (p < 0.001), and LVSWI (p = 0.018) and decreased SVRI (p < 0.001; all AVP-Dobu versus AVP group at dobutamine 10 ?
Negative_regulation (decreased) of Gene_expression (group) of AVP
8) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.06 Pain Relevance 0
Dobutamine increased MAP (p = 0.009), CI (p < 0.001), HR (p < 0.001), and LVSWI (p = 0.018) and decreased SVRI (p < 0.001; all AVP-Dobu versus AVP group at dobutamine 10 ?
Negative_regulation (decreased) of Gene_expression (group) of AVP-Dobu
9) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.06 Pain Relevance 0
The underlying mechanisms leading to cold-induced diuresis include increased venous return caused by constriction of peripheral vessels (particularly in the skin) due to hypothermia-induced increases in plasma noradrenaline levels and activation of the sympathetic nerve system, activation of atrial natriuretic peptide, decreased levels of antidiuretic hormone and renal antidiuretic hormone receptor levels, and tubular dysfunction [23,24].
Negative_regulation (decreased) of Gene_expression (levels) of antidiuretic hormone in plasma associated with natriuresis, diuresis, hypothermia and noradrenaline
10) Confidence 0.24 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2998647 Disease Relevance 1.29 Pain Relevance 0.05
The various mechanisms underlying inappropriately low circulating vasopressin levels may include increased vasopressin clearance from plasma, depleted vasopressin stores after the initial release, impaired baroreflex or osmoreceptor sensitivity, cytokines, or NO-induced decreased vasopressin synthesis or release [126-129].
Negative_regulation (decreased) of Gene_expression (synthesis) of vasopressin in plasma associated with cytokine
11) Confidence 0.15 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.26 Pain Relevance 0.10
First, deficiency implicitly suggests that plasma vasopressin levels are abnormally reduced.
Negative_regulation (reduced) of Gene_expression (levels) of vasopressin in plasma
12) Confidence 0.15 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 1.17 Pain Relevance 0
All but 1 patient with pain relief exhibited a lack of antidiuretic hormone (ADH) production.
Negative_regulation (lack) of Gene_expression (production) of antidiuretic hormone associated with pain
13) Confidence 0.11 Published 1980 Journal Neurosurgery Section Abstract Doc Link 6991970 Disease Relevance 0.85 Pain Relevance 0.58

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