INT108480

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 53
Total Number 57
Disease Relevance 37.87
Pain Relevance 14.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
skin 8
vessels 4
glands 3
endometrium 2
blood 2
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1384 100.00 Very High Very High Very High
imagery 4 100.00 Very High Very High Very High
Inflammation 638 99.98 Very High Very High Very High
intrathecal 4 99.98 Very High Very High Very High
psoriasis 62 99.86 Very High Very High Very High
rheumatoid arthritis 193 99.84 Very High Very High Very High
endometriosis 700 99.40 Very High Very High Very High
Multiple sclerosis 20 99.32 Very High Very High Very High
Neuritis 12 98.84 Very High Very High Very High
Inflammatory response 51 93.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 711 99.98 Very High Very High Very High
Psoriasis 62 99.86 Very High Very High Very High
Rheumatoid Arthritis 193 99.84 Very High Very High Very High
Endometriosis 810 99.40 Very High Very High Very High
Demyelinating Disease 20 99.32 Very High Very High Very High
Inflammatory Bowel Disease 93 99.30 Very High Very High Very High
Contact Dermatitis 713 99.24 Very High Very High Very High
Neurological Disease 14 99.22 Very High Very High Very High
Optic Neuritis 12 98.84 Very High Very High Very High
Stress 197 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Around the same time Saeki et al demonstrated that CCL21 production by LEC is crucial for the emigration of murine CCR7+ mature LC from the dermal compartment [1].
Gene_expression (production) of CCL21
1) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.45 Pain Relevance 0.18
In this regard, Katou et al. have shown by RT-PCR and immunohistochemistry CCL21 expression only in LEC from chronically inflamed skin infected with Candida albicans.
Gene_expression (expression) of CCL21 in skin associated with candida infection
2) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.17 Pain Relevance 0.27
CCL21 expression by HEV has been reported to be involved in CCR7+ naive lymphocytes recruitment in secondary lymphoid organs in human and mice [22-24].
Gene_expression (expression) of CCL21 in lymphocytes
3) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.62 Pain Relevance 0.18
Since Langerin is a marker of immature LC [27], we speculate that under this inflammatory condition the increased production of CCL21 could facilitate the emigration of CCR7+ cells through lymphatic vessels.
Gene_expression (production) of CCL21 in lymphatic vessels associated with inflammation
4) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.45 Pain Relevance 0.13
Weninger et al performing immunofluorescence staining found CCL21 expression by BEC from rheumatoid arthritis and ulcerative colitis biopsies, but not psoriasis where CCL21+ vessels were rare [13].
Gene_expression (expression) of CCL21 in vessels associated with psoriasis, inflammatory bowel disease and rheumatoid arthritis
5) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.19 Pain Relevance 0.42
Two pathologists examined all the slides blindly and made a semiquantitative assessment of dermis infiltration, congested or dilated vessels, vesicles, spongiosis and levels of expression of CCL21.
Gene_expression (expression) of CCL21 in vessels
6) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.10 Pain Relevance 0.06
We reported here that all normal skin biopsies express low levels of CCL21 in LEC.
Gene_expression (express) of CCL21 in skin
7) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.58 Pain Relevance 0.28
Our previous studies and other investigations did not find CCL21 expression by LEC in normal human skin.
Gene_expression (expression) of CCL21 in skin
8) Confidence 0.77 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.28 Pain Relevance 0.24
In the control cohort, CCL21 mRNA expression ranged between 0.003 – 0.045 fg/pg 18S RNA.
Gene_expression (expression) of CCL21 mRNA
9) Confidence 0.72 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.67 Pain Relevance 0.43
These combined data clearly show that the expression of CCL16 and CCL21 is disturbed at least in some patients with endometriosis.
Gene_expression (expression) of CCL21 associated with endometriosis
10) Confidence 0.72 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.69 Pain Relevance 0.48
Later on, Gunn et al found CCL21 expression HEV from secondary lymphoid organs and lymphatics from several murine tissues [22].
Gene_expression (expression) of CCL21
11) Confidence 0.67 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.65 Pain Relevance 0.19
Using Northern blot analysis they found human CCL21 expression restricted to lymphoid organs, while murine CCL21 showed a broader tissue distribution with the highest mRNA levels found in spleen and lung.
Gene_expression (expression) of CCL21 in lung
12) Confidence 0.67 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.94 Pain Relevance 0.18
These data identify CCL21 expression by BEC as an important determinant for naive T cell migration to tertiary lymphoid tissues, and suggest the CCL21/CCR7 pathway as a therapeutic target in diseases associated with naive T cell recruitment.
Gene_expression (expression) of CCL21 in naive T cell associated with disease
13) Confidence 0.67 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.33 Pain Relevance 0.36
We reported here that all normal skin biopsies express low levels of CCL21 in LEC.
Gene_expression (levels) of CCL21 in skin
14) Confidence 0.66 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.58 Pain Relevance 0.28
The results of this study are not intended to put an end to the controversy regarding the Asiatic or European origin [5,6], for this would require genotypic identification of ancestral H. pylori and comparison with prevalent types in Europe and Asia [4,8,9], as, for example, that the vacA gene's slc allele is isolated only in Asiatic individuals [25].
Gene_expression (allele) of slc
15) Confidence 0.65 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2483284 Disease Relevance 0.54 Pain Relevance 0.06
Real-time PCR verified that there were differences in the mRNA encoding CCL16 and CCL21, the two chemokines selected for further study, but that there was considerable heterogeneity in expression in individual endometriosis subjects.
Gene_expression (expression) of CCL21 associated with endometriosis and chemokine
16) Confidence 0.62 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.55 Pain Relevance 0.44
CCL21 mRNA was more abundant than that of CCL16 and was markedly elevated in eutopic glands from one endometriosis patient (mean, 0.61 fg/pg 18S RNA) (Figure 2B).
Gene_expression (abundant) of CCL21 mRNA in glands associated with endometriosis
17) Confidence 0.62 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.61 Pain Relevance 0.37
CCL16 protein was detected in the glandular epithelium of all but one of the 32 tissues examined and CCL21 protein was evident in glands in all tissues.
Spec (evident) Gene_expression (evident) of CCL21 protein in glands
18) Confidence 0.62 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.49 Pain Relevance 0.43
When we investigated levels of CCL21 expression in the skin biopsies obtained at different times from one ICD patient we observed moderate levels of this chemokine at 10 hours, which further increased at 48 hours and declined thereafter (Figure 2).
Gene_expression (expression) of CCL21 in skin associated with chemokine and contact dermatitis
19) Confidence 0.59 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.81 Pain Relevance 0.15
Positive correlation was found when we compared the macroscopic response with CCL21 expression (r = 0.69; p = 0.0008; CI = 0.34–0.87) but there was no correlation between the number of infiltrating cells and CCL21 expression in all the patients studied (r = 0.29; p = 0.2155; CI = -0.19–0.66).


Gene_expression (expression) of CCL21
20) Confidence 0.59 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.03 Pain Relevance 0.07

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