INT108481

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 15.22
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL19) extracellular region (CCL19)
Anatomy Link Frequency
lymph nodes 6
blood 3
B cells 1
lung 1
CCL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 70 100.00 Very High Very High Very High
Multiple sclerosis 20 99.84 Very High Very High Very High
intrathecal 4 99.70 Very High Very High Very High
Neuritis 12 99.36 Very High Very High Very High
Inflammation 23 99.26 Very High Very High Very High
Inflammatory response 19 98.34 Very High Very High Very High
cytokine 82 98.16 Very High Very High Very High
agonist 54 97.08 Very High Very High Very High
Central nervous system 8 97.04 Very High Very High Very High
ketamine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 241 99.84 Very High Very High Very High
Demyelinating Disease 20 99.84 Very High Very High Very High
Infection 877 99.74 Very High Very High Very High
Neurological Disease 14 99.44 Very High Very High Very High
Optic Neuritis 12 99.36 Very High Very High Very High
INFLAMMATION 40 99.26 Very High Very High Very High
Disease Progression 126 97.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 369 97.44 Very High Very High Very High
Apoptosis 243 97.40 Very High Very High Very High
Hematological Disease 9 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, constant inflammatory signals provided by the significant increase in several chemokines (CCL2, CCL3, CCL19, CXCL8, CXCL10, CXCL11) and pro-inflammatory cytokines (IL6, IL17, IL1A, IL1B, TNF) in the lung cells may have resulted in massive infiltration of leucocytes and excessive tissue damage.
Positive_regulation (increase) of CCL19 in lung associated with chemokine, inflammation and cytokine
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.61 Pain Relevance 0.29
We now provide evidence of a functional link between CCL19 upregulation in lymph nodes and increased expression of CCR7 on circulating mDC that promotes mDC recruitment to lymph nodes in progressive SIV infection.
Positive_regulation (upregulation) of CCL19 in lymph nodes associated with infection
2) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.01 Pain Relevance 0.08
The lack of an upregulated CCR7-CCL19 axis in this group would exacerbate the impact of enhanced DC production and mobilization into blood by limiting mDC exodus into tissues.
Positive_regulation (upregulated) of CCL19 in blood
3) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.40 Pain Relevance 0.10
These data suggest that mDC are mobilized in SIV infection but that an increase in the CCR7-CCL19 chemokine axis associated with high virus burden in progressive infection promotes exodus of activated mDC from blood into lymph nodes where they die from apoptosis.
Positive_regulation (increase) of CCL19 in blood associated with chemokine, apoptosis and infection
4) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009592 Disease Relevance 1.29 Pain Relevance 0.10
The role of elevated CCL19 and CCL21 in MS could be retention of mature dendritic cells (DC) in the CNS, recruitment of nai;ve T cells and activated B cells, as well as de novo formation of secondary lymphoid structures in MS plaques.
Positive_regulation (elevated) of CCL19 in B cells associated with multiple sclerosis and central nervous system
5) Confidence 0.32 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.33 Pain Relevance 1.46
We found that CCL19 but not CCL21 mRNA was increased 8-fold in lymph nodes at 12 weeks post infection, but only in animals that progressed to AIDS (Figure 4E).
Positive_regulation (increased) of CCL19 in lymph nodes associated with acquired immune deficiency syndrome or hiv infection and infection
6) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.91 Pain Relevance 0
The lack of mDC accumulation in lymph nodes despite evidence for enhanced CCR7/CCL19-mediated recruitment in progressive infection led us to suspect that lymph node mDC were dying at an increased rate in these tissues.
Positive_regulation (enhanced) of CCL19 in lymph nodes associated with infection
7) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.04 Pain Relevance 0
Collectively, these data suggest that the inflammatory response associated with increased virus load during progressive SIV infection leads to an increase in the CCR7-CCL19 chemokine axis that serves to accelerate mDC recruitment to lymph nodes.
Positive_regulation (increase) of CCL19 in lymph nodes associated with chemokine, inflammatory response and infection
8) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.25 Pain Relevance 0.13
Together with our findings in blood, these data suggest that mDC are recruited to lymph nodes in progressive disease via an enhanced CCR7/CCL19 pathway, but that expanded mDC recruitment fails to result in mDC accumulation.


Positive_regulation (enhanced) of CCL19 in lymph nodes associated with disease
9) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.88 Pain Relevance 0
The lack of mDC accumulation in lymph nodes despite evidence for enhanced CCR7/CCL19-mediated recruitment in progressive infection led us to suspect that lymph node mDC were dying at an increased rate in these tissues.
Positive_regulation (accumulation) of CCL19 in lymph nodes associated with infection
10) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0
Indeed, recent studies have shown that increased levels of CCL19 and CCL21 in blood correlate with higher virus loads and disease progression in HIV infected humans [30].
Positive_regulation (increased) of CCL19 in blood associated with acquired immune deficiency syndrome or hiv infection and disease progression
11) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0.08
Intrathecal production of CCL19 and CCL21 was elevated in MS, MS-type ON, and OIND, but not in non-MS-type ON.
Positive_regulation (elevated) of CCL19 associated with multiple sclerosis, neurological disease, neuritis and intrathecal
12) Confidence 0.13 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.38 Pain Relevance 1.53

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