INT108482

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 9.72
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
stromal cell 2
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 99.98 Very High Very High Very High
intrathecal 2 99.98 Very High Very High Very High
Arthritis 29 99.44 Very High Very High Very High
antagonist 43 97.92 Very High Very High Very High
chemokine 310 97.40 Very High Very High Very High
Multiple sclerosis 11 97.04 Very High Very High Very High
Neuritis 6 96.76 Very High Very High Very High
Inflammation 95 96.60 Very High Very High Very High
rheumatoid arthritis 35 94.92 High High
Central nervous system 12 90.80 High High
Disease Link Frequency Relevance Heat
Neurological Disease 7 99.64 Very High Very High Very High
Metastasis 123 99.60 Very High Very High Very High
Colon Cancer 42 99.52 Very High Very High Very High
Arthritis 30 99.44 Very High Very High Very High
Endometrial Cancer 6 99.16 Very High Very High Very High
Pressure And Volume Under Development 22 98.56 Very High Very High Very High
Cancer 556 97.48 Very High Very High Very High
Demyelinating Disease 11 97.04 Very High Very High Very High
Optic Neuritis 6 96.76 Very High Very High Very High
INFLAMMATION 104 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As far as endometrial cancer, studies on CXCR4 and CXCL12 expression revealed that CXCR4 is overexpressed in endometrial cancers as compared with normal tissues, whereas CXCL12 was overexpressed in normal mucosa.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CXCL12 associated with endometrial cancer
1) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.38 Pain Relevance 0
The chemokine ligand/receptor pair stromal cell-derived factor-1 (SDF-1, CXCL12)/CXCR4 is gaining increasing interest because of its involvement in the metastasis of several types of cancer and in certain inflammatory autoimmune disorders such as rheumatoid arthritis.
Positive_regulation (increasing) of Gene_expression (gaining) of SDF-1 in stromal cell associated with autoimmune disease, inflammation, cancer, rheumatoid arthritis and metastasis
2) Confidence 0.50 Published 2004 Journal Cytometry A Section Abstract Doc Link 15382150 Disease Relevance 0.72 Pain Relevance 0.30
In conclusion, preoperatively intravenous injection of LOR may effectively restrain the decreased serum levels of RANTES and the increased expression of MCP-1 and SDF-1alpha in TAH patients.
Positive_regulation (increased) of Gene_expression (expression) of SDF-1alpha
3) Confidence 0.49 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19966527 Disease Relevance 0.25 Pain Relevance 0.20
reduced with CXCL12-KDEL-transfected cells, and survival was increased.
Positive_regulation (increased) of Gene_expression (reduced) of CXCL12
4) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.23 Pain Relevance 0
transfected with CXCL12 extended with a Lys-Asp-Glu-Leu (KDEL) sequence.
Positive_regulation (transfected) of Gene_expression (transfected) of CXCL12
5) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.53 Pain Relevance 0
1 may be one of these factors increasing CXCL12 production.
Positive_regulation (increasing) of Gene_expression (production) of CXCL12
6) Confidence 0.31 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.44 Pain Relevance 0.05
In arthritis, proinflammatory cytokines stimulate the production of SDF-1/CXCL12 and thus tissue vasculogenesis by recruiting CXCR4+ EPCs [14,17,29].


Positive_regulation (stimulate) of Gene_expression (production) of SDF-1 associated with cytokine and arthritis
7) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.87 Pain Relevance 0.33
Intrathecal production of CXCL12 was elevated only in OIND.
Positive_regulation (elevated) of Gene_expression (production) of CXCL12 associated with neurological disease and intrathecal
8) Confidence 0.15 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.29 Pain Relevance 1.48

General Comments

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