INT108483

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.76
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
lymphatic vessels 4
blood 2
Vessels 2
skin 2
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
Multiple sclerosis 10 99.84 Very High Very High Very High
Inflammation 77 99.70 Very High Very High Very High
Neuritis 6 99.36 Very High Very High Very High
chemokine 135 95.00 High High
rheumatoid arthritis 64 94.04 High High
Central nervous system 4 77.28 Quite High
Inflammatory response 6 73.84 Quite High
psoriasis 10 41.48 Quite Low
cytokine 16 39.12 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 10 99.84 Very High Very High Very High
INFLAMMATION 84 99.70 Very High Very High Very High
Optic Neuritis 6 99.36 Very High Very High Very High
Neurological Disease 7 99.04 Very High Very High Very High
Rheumatoid Arthritis 64 94.04 High High
Contact Dermatitis 115 93.84 High High
Allergic Dermatitis 105 93.72 High High
Nervous System Inflammation 1 75.00 Quite High
Stress 32 71.04 Quite High
Candida Infection 5 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since Langerin is a marker of immature LC [27], we speculate that under this inflammatory condition the increased production of CCL21 could facilitate the emigration of CCR7+ cells through lymphatic vessels.
Positive_regulation (increased) of Gene_expression (production) of CCL21 in lymphatic vessels associated with inflammation
1) Confidence 0.69 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.45 Pain Relevance 0.13
Around the same time Saeki et al demonstrated that CCL21 production by LEC is crucial for the emigration of murine CCR7+ mature LC from the dermal compartment [1].
Positive_regulation (crucial) of Gene_expression (production) of CCL21
2) Confidence 0.49 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.45 Pain Relevance 0.18
Our previous studies and other investigations did not find CCL21 expression by LEC in normal human skin.
Neg (not) Spec (find) Positive_regulation (find) of Gene_expression (expression) of CCL21 in skin
3) Confidence 0.49 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.28 Pain Relevance 0.24
Kinetic study at 10, 48, 96 and 168 hours after contact with a classical irritant (sodium lauryl sulphate) showed that the expression of CCL21 was increased in lymphatic vessels at 10 hours, peaked at 48 hours, and then gradually declined.
Positive_regulation (increased) of Gene_expression (expression) of CCL21 in lymphatic vessels
4) Confidence 0.46 Published 2004 Journal BMC Immunol Section Abstract Doc Link PMC419342 Disease Relevance 0.87 Pain Relevance 0.17
Vessels expressing CCL21 were also positive for Prox-1, however we could not get good quality pictures with this antibody (data not shown).
Positive_regulation (positive) of Gene_expression (expressing) of CCL21 in Vessels
5) Confidence 0.40 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.78 Pain Relevance 0.08
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Positive_regulation (upregulated) of Gene_expression (expression) of CCL21 mRNA in blood
6) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.23 Pain Relevance 0.12
Under each loading condition, the predicted displacement values after TPC insertion were smaller than those after DPC and SLC insertion (Figure 5a).
Positive_regulation (after) of Gene_expression (insertion) of SLC
7) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2442839 Disease Relevance 0.30 Pain Relevance 0
Intrathecal production of CCL19 and CCL21 was elevated in MS, MS-type ON, and OIND, but not in non-MS-type ON.
Positive_regulation (elevated) of Gene_expression (production) of CCL21 associated with multiple sclerosis, neurological disease, neuritis and intrathecal
8) Confidence 0.20 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.39 Pain Relevance 1.54

General Comments

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