INT108484

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 12.56
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL19) extracellular region (CCL19)
Anatomy Link Frequency
lymph nodes 6
blood 1
CSF 1
T cells 1
CCL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 55 99.98 Very High Very High Very High
intrathecal 4 99.98 Very High Very High Very High
Multiple sclerosis 20 99.88 Very High Very High Very High
Neuritis 12 99.48 Very High Very High Very High
Inflammation 49 98.34 Very High Very High Very High
cytokine 50 96.78 Very High Very High Very High
agonist 42 87.36 High High
Inflammatory response 14 87.12 High High
Central nervous system 8 83.92 Quite High
rheumatoid arthritis 1 57.52 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 20 99.88 Very High Very High Very High
Infection 673 99.66 Very High Very High Very High
Optic Neuritis 12 99.48 Very High Very High Very High
Disease 180 99.04 Very High Very High Very High
Neurological Disease 14 98.40 Very High Very High Very High
INFLAMMATION 61 98.34 Very High Very High Very High
Disease Progression 98 97.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 291 96.76 Very High Very High Very High
Skin Cancer 2 93.04 High High
Adenocarcinoma 90 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal production of CCL19 and CCL21 was elevated in MS, MS-type ON, and OIND, but not in non-MS-type ON.
Gene_expression (production) of CCL19 associated with multiple sclerosis, neurological disease, neuritis and intrathecal
1) Confidence 0.50 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.38 Pain Relevance 1.53
This eventual decline may be associated with a similar decline in lymph node expression of CCL19 in the final stages of disease [29].
Gene_expression (expression) of CCL19 in lymph node associated with disease
2) Confidence 0.41 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.46 Pain Relevance 0
mDC do not accumulate in lymph nodes despite increased tissue CCL19 expression
Gene_expression (expression) of CCL19 in lymph nodes
3) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.67 Pain Relevance 0.03
CCL19 induces terminal activation of DC and promotes DC production of proinflammatory cytokines within lymph nodes [54], although this effect would not explain the finding of increased responsiveness of mDC in animals with stable infection that had normal levels of CCL19 in our study.
Gene_expression (levels) of CCL19 in lymph nodes associated with infection and cytokine
4) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.67 Pain Relevance 0.09
In MS, CSF levels of CCL19 weakly correlated with CSF cell counts.
Gene_expression (levels) of CCL19 in CSF associated with multiple sclerosis
5) Confidence 0.34 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.34 Pain Relevance 1.51
CCR6 regulates the migration and recruitment of DCs and T cells during inflammation, whereas CCR7 controls the migration of DCs and T cells to lymphoid organs due to production of CCL19 and CCL21 at these sites [44].
Gene_expression (production) of CCL19 in T cells associated with inflammation
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.01 Pain Relevance 0.20
mDC are recruited from blood to lymphoid tissues through upregulation of CCR7, the ligand for chemokines CCL19 and CCL21 that are expressed in the lymph node paracortex [28].
Gene_expression (expressed) of CCL19 in lymph node associated with chemokine
7) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.93 Pain Relevance 0.05
Indeed, recent studies have shown that increased levels of CCL19 and CCL21 in blood correlate with higher virus loads and disease progression in HIV infected humans [30].
Gene_expression (levels) of CCL19 in blood associated with acquired immune deficiency syndrome or hiv infection and disease progression
8) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0.08
Expression of CCL19 has been shown previously to be markedly increased in lymph nodes during the acute phase of SIV infection [29], and our data suggest that expression in lymph nodes remains high into chronic infection as a function of virus load.
Gene_expression (Expression) of CCL19 in lymph nodes associated with infection
9) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.04 Pain Relevance 0.07
In animals with progressive infection, mDC loss from blood was associated with an increase in the frequency of blood mDC expressing CCR7 and an increase in expression of CCL19 in lymph nodes, consistent with increased extravasation to lymph nodes that exceeded the rate of mDC production from bone marrow.
Gene_expression (expression) of CCL19 in lymph nodes associated with infection
10) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.01 Pain Relevance 0.07

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