INT108485

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 61
Total Number 62
Disease Relevance 49.34
Pain Relevance 13.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
stromal cell 6
dental pulp 3
neuronal 2
neurons 2
T cell 2
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2508 100.00 Very High Very High Very High
Inflammation 590 100.00 Very High Very High Very High
cytokine 259 100.00 Very High Very High Very High
agonist 91 100.00 Very High Very High Very High
intrathecal 2 99.98 Very High Very High Very High
rheumatoid arthritis 398 99.84 Very High Very High Very High
Arthritis 71 99.16 Very High Very High Very High
Dopamine 664 97.92 Very High Very High Very High
antagonist 347 97.92 Very High Very High Very High
Multiple sclerosis 14 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 672 100.00 Very High Very High Very High
Herpes Simplex Virus 476 100.00 Very High Very High Very High
Ovarian Cancer 1586 99.98 Very High Very High Very High
Metastasis 934 99.92 Very High Very High Very High
Cancer 4543 99.84 Very High Very High Very High
Rheumatoid Arthritis 398 99.84 Very High Very High Very High
Breast Cancer 530 99.70 Very High Very High Very High
Endometrial Cancer 54 99.54 Very High Very High Very High
Colon Cancer 296 99.52 Very High Very High Very High
Arthritis 72 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of vascular endothelial growth factor (VEGF) and granulocyte colony-stimulating factor (G-CSF), peripheral blood progenitor cell counts, level of regional angiogenesis, and expression of VEGF and stromal cell derived factor 1alpha (SDF-1alpha) in porcine myocardium were assessed, respectively.
Gene_expression (expression) of stromal cell derived factor in granulocyte
1) Confidence 0.75 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19493469 Disease Relevance 0 Pain Relevance 0
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Gene_expression (expressed) of CXCL12 in neurons associated with chemokine and inflammation
2) Confidence 0.75 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.73
In conclusion, preoperatively intravenous injection of LOR may effectively restrain the decreased serum levels of RANTES and the increased expression of MCP-1 and SDF-1alpha in TAH patients.
Gene_expression (expression) of SDF-1alpha
3) Confidence 0.75 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19966527 Disease Relevance 0.25 Pain Relevance 0.20
the ligand CXCL12 was highly expressed in tissues taken from human organ sites
Gene_expression (expressed) of CXCL12
4) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.26 Pain Relevance 0.03
CXCR4, and are attracted to CXCL12 produced by stromal cells in specialized bone
Gene_expression (produced) of CXCL12 in stromal cells
5) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.38 Pain Relevance 0.07
The chemokine ligand/receptor pair stromal cell-derived factor-1 (SDF-1, CXCL12)/CXCR4 is gaining increasing interest because of its involvement in the metastasis of several types of cancer and in certain inflammatory autoimmune disorders such as rheumatoid arthritis.
Gene_expression (gaining) of SDF-1 in stromal cell associated with autoimmune disease, inflammation, cancer, rheumatoid arthritis and metastasis
6) Confidence 0.67 Published 2004 Journal Cytometry A Section Abstract Doc Link 15382150 Disease Relevance 0.72 Pain Relevance 0.30
As far as endometrial cancer, studies on CXCR4 and CXCL12 expression revealed that CXCR4 is overexpressed in endometrial cancers as compared with normal tissues, whereas CXCL12 was overexpressed in normal mucosa.
Gene_expression (expression) of CXCL12 associated with endometrial cancer
7) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.34 Pain Relevance 0
However, in consideration that 91% and 59% of ovarian cancers express CXCL12 and CXCR4, respectively, it was proposed that an overexpression of this chemokine system was present in ovarian malignant cells.
Gene_expression (express) of CXCL12 associated with chemokine, malignant neoplastic disease and ovarian cancer
8) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.08 Pain Relevance 0.09
As far as endometrial cancer, studies on CXCR4 and CXCL12 expression revealed that CXCR4 is overexpressed in endometrial cancers as compared with normal tissues, whereas CXCL12 was overexpressed in normal mucosa.
Gene_expression (overexpressed) of CXCL12 associated with endometrial cancer
9) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.38 Pain Relevance 0
More recent detailed analysis showed the expression of CXCR4 and CXCL12 also in normal ovary, but their localization was confined to the follicular cells and it was not detected in normal epithelium [82].
Gene_expression (expression) of CXCL12 in ovary
10) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.14 Pain Relevance 0.14
In contrast, papillary serous and endometrioid ovarian tumors display a high expression of CXCL12.
Gene_expression (expression) of CXCL12 associated with ovarian cancer
11) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.34 Pain Relevance 0.11
In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization.
Gene_expression (expression) of CXCL12 associated with cancer
12) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2798669 Disease Relevance 0.71 Pain Relevance 0.28
However, HER2/neu positive patients did not show a higher expression of cytoplasmic CXCR4 staining, which was positive in over half of the cases and closely correlated with CXCL12 expression [87].
Gene_expression (expression) of CXCL12
13) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.88 Pain Relevance 0
Subsequently, CXCR4 and CXCL12 expression in ovarian cancer have been confirmed by other studies [78, 82, 83].
Gene_expression (expression) of CXCL12 associated with ovarian cancer
14) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.17 Pain Relevance 0.14
In these types of cancer, distant metastasis, favored by CXCL12 expression on target organs, significantly influences the survival, while in ovarian cancer the recurrence in the pelvis and in the peritoneum is the main cause for death.
Gene_expression (expression) of CXCL12 in peritoneum associated with cancer, ovarian cancer, death, recurrence and metastasis
15) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.61 Pain Relevance 0.03
In addition, the CXCR4/CXCL12 expression was associated with unfavorable prognosis with significantly reduced median disease progression-free survival [82].
Gene_expression (expression) of CXCL12 associated with disease progression
16) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.09 Pain Relevance 0.09
The published studies dealing with the expression of CXCL12 and CXCR4 in human ovarian cancer cell lines, tumor biopsies and ascite cells are summarized in Tables 1 and 2, respectively.
Gene_expression (expression) of CXCL12 associated with cancer and ovarian cancer
17) Confidence 0.59 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.53 Pain Relevance 0.09
transfected with CXCL12 extended with a Lys-Asp-Glu-Leu (KDEL) sequence.
Gene_expression (transfected) of CXCL12
18) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.53 Pain Relevance 0
With this

“intrakine approach," CXCL12-KDEL binds to the KDEL receptor and is retained in

Gene_expression (retained) of CXCL12
19) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.49 Pain Relevance 0
ITS LIGAND CXCL12 (SDF-1)
Gene_expression (ITS) of CXCL12
20) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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