INT108486

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 6.20
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL19) extracellular region (CCL19)
Anatomy Link Frequency
lymph nodes 6
blood 2
CCL19 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
Multiple sclerosis 10 99.84 Very High Very High Very High
Neuritis 6 99.36 Very High Very High Very High
Inflammation 8 95.60 Very High Very High Very High
chemokine 27 91.40 High High
Inflammatory response 8 87.12 High High
Central nervous system 4 77.28 Quite High
cytokine 28 34.04 Quite Low
agonist 24 27.36 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 10 99.84 Very High Very High Very High
Optic Neuritis 6 99.36 Very High Very High Very High
Neurological Disease 7 99.04 Very High Very High Very High
Infection 384 98.16 Very High Very High Very High
Disease Progression 56 97.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 164 97.04 Very High Very High Very High
INFLAMMATION 15 95.60 Very High Very High Very High
Nervous System Inflammation 1 75.00 Quite High
Disease 100 52.56 Quite High
Immunodeficiency 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal production of CCL19 and CCL21 was elevated in MS, MS-type ON, and OIND, but not in non-MS-type ON.
Positive_regulation (elevated) of Gene_expression (production) of CCL19 associated with multiple sclerosis, neurological disease, neuritis and intrathecal
1) Confidence 0.45 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12576236 Disease Relevance 2.39 Pain Relevance 1.54
mDC do not accumulate in lymph nodes despite increased tissue CCL19 expression
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CCL19 in lymph nodes
2) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.68 Pain Relevance 0.03
In animals with progressive infection, mDC loss from blood was associated with an increase in the frequency of blood mDC expressing CCR7 and an increase in expression of CCL19 in lymph nodes, consistent with increased extravasation to lymph nodes that exceeded the rate of mDC production from bone marrow.
Positive_regulation (increase) of Gene_expression (expression) of CCL19 in lymph nodes associated with infection
3) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.01 Pain Relevance 0.07
Expression of CCL19 has been shown previously to be markedly increased in lymph nodes during the acute phase of SIV infection [29], and our data suggest that expression in lymph nodes remains high into chronic infection as a function of virus load.
Positive_regulation (increased) of Gene_expression (Expression) of CCL19 in lymph nodes associated with infection
4) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0.08
Indeed, recent studies have shown that increased levels of CCL19 and CCL21 in blood correlate with higher virus loads and disease progression in HIV infected humans [30].
Positive_regulation (increased) of Gene_expression (levels) of CCL19 in blood associated with acquired immune deficiency syndrome or hiv infection and disease progression
5) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0.08

General Comments

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