INT10849

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.51
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OXT) extracellular space (OXT) extracellular region (OXT)
response to stress (OXT) cytoplasm (OXT)
Anatomy Link Frequency
plasma 3
myometrium 1
uterus 1
cerebrospinal fluid 1
uterine 1
OXT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 48 100.00 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
Endogenous opioid 5 99.80 Very High Very High Very High
Somatostatin 10 99.08 Very High Very High Very High
narcan 19 97.56 Very High Very High Very High
Nicotine 4 97.44 Very High Very High Very High
antagonist 20 96.52 Very High Very High Very High
Neuropeptide 3 96.32 Very High Very High Very High
Potency 7 94.88 High High
agonist 8 93.40 High High
Disease Link Frequency Relevance Heat
Dysmenorrhea 39 100.00 Very High Very High Very High
Prolonged Pregnancy 1 97.36 Very High Very High Very High
Nicotine Addiction 5 97.04 Very High Very High Very High
Reprotox - General 1 8 96.60 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 95.60 Very High Very High Very High
Hypoglycemia 5 89.60 High High
Lumbar Puncture Related Headaches 4 88.28 High High
Low Back Pain 1 83.56 Quite High
Disease 4 75.00 Quite High
Targeted Disruption 3 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.
Negative_regulation (decreases) of oxytocin in cerebrospinal fluid associated with clonidine
1) Confidence 0.48 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.45
Vasopressin levels for these patients (3.6 +/- 0.4 fmol/ml) were also significantly reduced to 51% of controls (p less than 0.007) and oxytocin levels were marginally (p = 0.092) reduced to 70% of controls.
Negative_regulation (reduced) of oxytocin
2) Confidence 0.42 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.38 Pain Relevance 0.13
OT, in which the entire coding sequence of the OT-neurophysin I gene was replaced by the gene for neomycin-resistance, was linearized and transfected into TC1 and D3 embryonic stem (ES) cells.
Negative_regulation (replaced) of neurophysin I in stem
3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0.06 Pain Relevance 0.06
We conclude that there is endogenous opioid-mediated inhibition of OT which prevents its release when AVP is secreted in response to nicotine in man.
Negative_regulation (inhibition) of OT associated with nicotine and endogenous opioid
4) Confidence 0.37 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3214943 Disease Relevance 0.43 Pain Relevance 0.62
Hypertonic saline resulted in similar significant rises of plasma osmolality and AVP in both groups and a small but significant decrease in OT.
Negative_regulation (decrease) of OT in plasma
5) Confidence 0.36 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2605788 Disease Relevance 0 Pain Relevance 0.46
Plasma OT concentrations rose significantly during ITT; the OT response was significantly reduced by the treatment with SRIH and increased in the presence of naloxone.
Negative_regulation (reduced) of OT in Plasma associated with narcan and somatostatin
6) Confidence 0.32 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2569658 Disease Relevance 0.33 Pain Relevance 0.92
The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin.
Negative_regulation (inhibitors) of oxytocin in uterus
7) Confidence 0.30 Published 1985 Journal Acta Obstet Gynecol Scand Section Title Doc Link 4061066 Disease Relevance 0 Pain Relevance 0
First, previous studies have shown that those on OT are not cognitively impaired [37], [50].
Negative_regulation (impaired) of OT
8) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0
In order to develop inhibitors of vasopressin (VP) and oxytocin (OXY) action on uterine activity, 1-deaminated vasotocin derivatives with modifications at positions 2, 4 and 8 were developed.
Negative_regulation (inhibitors) of oxytocin in uterine
9) Confidence 0.22 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 4061066 Disease Relevance 0 Pain Relevance 0
On pregnant myometrium, dE-TVT inhibited oxytocin action about as effectively as a five-fold stronger concentration of dE-OXY, and dE-VVT slightly less.
Negative_regulation (inhibited) of oxytocin in myometrium
10) Confidence 0.22 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 4061066 Disease Relevance 0.07 Pain Relevance 0.07
During long-term treatment, barusiban reduced IUP in OT-challenged monkeys; it delayed the onset of labour and lead to a prolonged pregnancy.
Negative_regulation (reduced) of OT associated with prolonged pregnancy and dismenorea
11) Confidence 0.18 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.46 Pain Relevance 0.46
We have also shown that the analogue 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-OT, which blocks both the OT and AVP V1a receptor sites, given by intravenous infusion inhibits both preterm labour and dysmenorrhoea, and this is in agreement with our receptor and contractility findings.
Negative_regulation (blocks) of OT associated with dismenorea
12) Confidence 0.17 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8714023 Disease Relevance 0.36 Pain Relevance 0.31
Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.
Negative_regulation (decreases) of oxytocin in plasma associated with clonidine
13) Confidence 0.16 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.45
Atosiban is a competitive inhibitor of the OXTR and blocks OXT-induced Ca2+ increase in myometrial cells in a reversible manner [60].
Negative_regulation (inhibitor) of OXT
14) Confidence 0.11 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.27

General Comments

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