INT108510

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Atpif1)
Atpif1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 68.92 Quite High
Injury 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen significantly inhibited the activity of mitochondrial ATPase by its cytotoxic metabolite NAPQI [N-acetyl-p-benzoquinone], which has the potential to react with sulfhydryl groups or through sulfhydryl group oxidation.
Negative_regulation (inhibited) of mitochondrial ATPase
1) Confidence 0.50 Published 2001 Journal Yao Xue Xue Bao Section Body Doc Link 12579967 Disease Relevance 0.07 Pain Relevance 0
Our results showed that the reduction of mitochondrial fluidity as well as the inhibitory effect of mitochondrial ATPase induced by acetaminophen were also reduced by bicyclol.
Negative_regulation (effect) of mitochondrial ATPase
2) Confidence 0.50 Published 2001 Journal Yao Xue Xue Bao Section Body Doc Link 12579967 Disease Relevance 0.06 Pain Relevance 0

General Comments

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