INT108519

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.47
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Lrp6) plasma membrane (Lrp6)
Anatomy Link Frequency
osteocyte 1
Lrp6 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 10 99.64 Very High Very High Very High
Codeine 2 94.56 High High
Morphine 2 93.00 High High
Serotonin 28 80.12 Quite High
antagonist 13 70.28 Quite High
midbrain 4 53.28 Quite High
agonist 4 28.56 Quite Low
Inflammation 2 23.60 Low Low
alcohol 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 16 95.28 Very High Very High Very High
Osteoporosis 46 93.52 High High
Bone Cancer 24 91.68 High High
Injury 19 88.80 High High
Disease 30 73.24 Quite High
Colitis 5 72.56 Quite High
Targeted Disruption 5 71.32 Quite High
Postmenopausal Osteoporosis 4 68.08 Quite High
Apoptosis 11 63.52 Quite High
Embryonic Lethality 4 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations were either in the gene encoding the low density lipoprotein receptor-related protein-5 (LRP5) or in a gene (SOST) encoding a protein (Sclerostin) that potentially binds and regulates the function of LRP5 and its family members LRP4 and LRP6.
LRP6 Binding (binds) of
1) Confidence 0.44 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.19 Pain Relevance 0.04
However, subsequent work demonstrated that it also bound Lrp5 and Lrp6 and could prevent their interaction with Wnts [17–19].
Lrp6 Binding (bound) of
2) Confidence 0.44 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.40 Pain Relevance 0.04
-catenin signaling via binding directly to LRP5 and LRP6 and blocked the ability of Wnt ligands to interact with LRP5 and LRP6 [80–82].
LRP6 Binding (interact) of
3) Confidence 0.34 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.25 Pain Relevance 0.03
Wnts initiate signaling by binding to a member of the Frizzled family of seven transmembrane receptors and either LRP5 or LRP6 [8–10] (Figure 1), leading to downregulation of glycogen synthase kinase-3 (GSK-3) activity.
LRP6 Binding (binding) of
4) Confidence 0.30 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.13
Recombinant LRP6 inhibits ?
LRP6 Binding (Recombinant) of
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993965 Disease Relevance 0.50 Pain Relevance 0
Sclerostin after secretion by osteocytes travels through osteocyte canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 thus preventing colocalization with frizzled protein and Wnt signaling, and thereby reducing osteoblastogenesis and bone formation [3].
LRP6 Binding (binds) of in osteocyte
6) Confidence 0.17 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.13 Pain Relevance 0
The separation was modelled using a migration equation derived from first principles and based on ion-exchange interactions between the s-CD and the opiates.
s-CD Binding (interactions) of associated with opiate
7) Confidence 0.00 Published 2003 Journal J Chromatogr A Section Abstract Doc Link 12580518 Disease Relevance 0 Pain Relevance 0.51
Cation-exchange interactions between the cationic analytes and the anionic s-CD (7-11 mol of sulfate groups per mole CD) were found to bethe predominant mechanism, allowing the separations to be performed at low pH where the opiates are protonated and exhibit very similar mobilities.
s-CD Binding (interactions) of associated with opiate
8) Confidence 0.00 Published 2003 Journal J Chromatogr A Section Abstract Doc Link 12580518 Disease Relevance 0 Pain Relevance 0.45

General Comments

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