INT108520

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpys) cytoplasm (Dpys)
Dpys (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 6 98.00 Very High Very High Very High
antinociception 3 97.60 Very High Very High Very High
Antinociceptive 9 92.72 High High
antagonist 2 85.12 High High
Cannabinoid 3 75.00 Quite High
intrathecal 1 48.52 Quite Low
Hyperalgesia 1 38.80 Quite Low
Spinal sensitization 1 38.12 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 81.28 Quite High
Nociception 3 72.36 Quite High
Hyperalgesia 1 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Propofol can inhibit fatty acid amidohydrolase, the enzyme responsible for the metabolism of anandamide (an endocannabinoid).
Negative_regulation (inhibit) of amidohydrolase associated with endocannabinoid
1) Confidence 0.12 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17513659 Disease Relevance 0 Pain Relevance 0.31
Finally. the combination of phenylmethylsulfonyl fluoride (PMSF; intraperitoneal), which inhibits the degradation of anandamide through the inhibition of fatty acid amidohydrolase, with thimerosal (i.th.) produced a profound CB1-dependent antinociception.
Negative_regulation (inhibition) of amidohydrolase associated with antinociception
2) Confidence 0.01 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12581177 Disease Relevance 0.21 Pain Relevance 0.60

General Comments

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