INT10854

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Context Info
Confidence 0.66
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 32
Disease Relevance 3.88
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OXT) extracellular space (OXT) extracellular region (OXT)
response to stress (OXT) cytoplasm (OXT)
Anatomy Link Frequency
plasma 6
neurons 5
hypothalamus 4
brain 1
OXT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 363 100.00 Very High Very High Very High
Dismenorea 34 98.08 Very High Very High Very High
Central nervous system 80 96.88 Very High Very High Very High
agonist 81 91.48 High High
backache 3 89.76 High High
amygdala 14 82.52 Quite High
isoflurane 40 82.00 Quite High
Dopamine 14 80.48 Quite High
alcohol 27 79.84 Quite High
depression 20 72.00 Quite High
Disease Link Frequency Relevance Heat
Disease 12 99.36 Very High Very High Very High
Dysmenorrhea 33 98.08 Very High Very High Very High
Natriuresis 20 96.08 Very High Very High Very High
Nicotine Addiction 20 94.84 High High
Anxiety Disorder 14 93.44 High High
Premature Birth 41 93.12 High High
Low Back Pain 3 89.76 High High
Pre-term Labor 41 89.24 High High
Nash(non-alcoholic Steatohepatitis) 7 85.68 High High
Stress 21 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An evaluation of human neurophysin production in Alzheimer's disease: preliminary observations.
Gene_expression (production) of neurophysin associated with disease
1) Confidence 0.66 Published 1992 Journal Neurobiol. Aging Section Title Doc Link 1522943 Disease Relevance 0.37 Pain Relevance 0.11
Because neurophysins and neuropeptides are gene-related products of vasopressin-neurons and oxytocin-neurons, the data indicate that these neurons are functionally impaired in patients with AD.
Gene_expression (products) of oxytocin in neurons associated with neuropeptide
2) Confidence 0.66 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.37 Pain Relevance 0.13
Concentrations of vasopressin and oxytocin were also measured.
Gene_expression (Concentrations) of oxytocin
3) Confidence 0.59 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.36 Pain Relevance 0.09
The effect was compared with that of a previously synthesized analogue 1-deamino-Tyr(OEt)-oxytocin (dE-OXY) which has already been tested in nonpregnant and pregnant women in vivo.
Gene_expression (synthesized) of oxytocin
4) Confidence 0.31 Published 1985 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 4061066 Disease Relevance 0 Pain Relevance 0
A least squares regression of generosity in the UG, controlling for the amount of altruism participants revealed in the dictator game, and a binary OT indicator showed that OT continues to be significantly associated with generosity (OT coeff. 0.648, two-tailed t-test p?
Gene_expression (continues) of OT
5) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0
Using the average minimum acceptable offer, we found that generosity was 80% higher in OT group than in the placebo group (OT mean: $1.89 (SD $1.06); placebo mean: $1.06 (SD $1.29); two-tailed Mann-Whitney U-test p?
Gene_expression (mean) of OT
6) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.08 Pain Relevance 0
The average money earned by the DM1s in the OT group was 5.2% lower than DM1s in the placebo group (OT mean: $4.91 (SD $1.27); placebo mean: $5.18 (SD $1.91); one-tailed Mann-Whitney U-test p?
Gene_expression (mean) of OT
7) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.06 Pain Relevance 0
Using the average minimum acceptable offer, we found that generosity was 80% higher in OT group than in the placebo group (OT mean: $1.89 (SD $1.06); placebo mean: $1.06 (SD $1.29); two-tailed Mann-Whitney U-test p?
Gene_expression (group) of OT
8) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.09 Pain Relevance 0
The average money earned by the DM1s in the OT group was 5.2% lower than DM1s in the placebo group (OT mean: $4.91 (SD $1.27); placebo mean: $5.18 (SD $1.91); one-tailed Mann-Whitney U-test p?
Gene_expression (mean) of OT
9) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.06 Pain Relevance 0
We did not find evidence that those given OT were more emotionally labile (using the Affective Intensity Measure [57], p?
Gene_expression (labile) of OT
10) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.18 Pain Relevance 0.11
A least squares regression of generosity in the UG, controlling for the amount of altruism participants revealed in the dictator game, and a binary OT indicator showed that OT continues to be significantly associated with generosity (OT coeff. 0.648, two-tailed t-test p?
Gene_expression (coeff.) of OT
11) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0
During OT infusion, about a fourfold increase occurred in overall IUP.
Gene_expression (infusion) of OT associated with dismenorea
12) Confidence 0.28 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.99 Pain Relevance 0.96
AVP and OT are two main neuropeptides synthesized by magnocellular neurosecretory neurons in the SON and PVN in the hypothalamus.
Gene_expression (synthesized) of OT in hypothalamus associated with neuropeptide
13) Confidence 0.17 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.05 Pain Relevance 0.23
The PVN is not only abundant of CRH neurons but also the main source for OT synthesis.
Gene_expression (source) of OT in neurons
14) Confidence 0.15 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.15 Pain Relevance 0.03
Therefore, those environmental and maternal factors could also subsequently produce a higher level of OT in utero according to the new finding in the present study.
Gene_expression (produce) of OT
15) Confidence 0.15 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.42 Pain Relevance 0.05
AVP and oxytocin (OT) are two major neuropeptides synthesized and released by magnocellular neurosecretory neurons in the hypothalamus.
Gene_expression (synthesized) of OT in hypothalamus associated with neuropeptide
16) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.10 Pain Relevance 0.25
AVP and oxytocin (OT) are two major neuropeptides synthesized and released by magnocellular neurosecretory neurons in the hypothalamus.
Gene_expression (synthesized) of oxytocin in hypothalamus associated with neuropeptide
17) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.10 Pain Relevance 0.25
Immediately following FOS immunostaining, tissue sections were used for double immunostaining by using AVP or OT antibody.
Gene_expression (antibody) of OT
18) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.10
The second phenomenon indicates that some of the AVP and OT neurons do not express FOS-ir following carbachol stimulation.
Gene_expression (neurons) of OT in neurons
19) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
There was no significant difference in plasma AVP and OT levels between the control and the experimental ewes to i.c.v. injection (AVP: F8,1 = 0.37, OT: F8,1 = 0.23, both P > 0.05).
Gene_expression (levels) of OT in plasma
20) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.03

General Comments

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