INT10855

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMC2) extracellular region (LAMC2) cell adhesion (LAMC2)
Anatomy Link Frequency
CSF 4
motor neurons 2
LAMC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 2 100.00 Very High Very High Very High
electroacupuncture 8 99.32 Very High Very High Very High
Spinal cord 1 98.84 Very High Very High Very High
opiate 2 95.72 Very High Very High Very High
Multiple sclerosis 1 91.40 High High
Neuritis 1 89.68 High High
Neuropeptide 1 86.72 High High
Potency 1 75.48 Quite High
backache 1 65.88 Quite High
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 99.92 Very High Very High Very High
Disease 6 99.46 Very High Very High Very High
Neuromyelitis Optica 9 99.30 Very High Very High Very High
Dementia 2 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 95.80 Very High Very High Very High
Transverse Myelitis 2 94.48 High High
Spasticity 3 94.12 High High
Relapsing-remitting Multiple Sclerosis 1 91.40 High High
Optic Neuritis 1 89.68 High High
Low Back Pain 1 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We infer that by enhancing the production of dynorphin in CSF, high-frequency EA decrease the excitability of the motor neurons in the anterior horns through the kappa opiate receptors, thus ameliorating the muscle spasticity of spinal origin.
Positive_regulation (enhancing) of Gene_expression (production) of CSF in motor neurons associated with spasticity, dynorphin, opiate and electroacupuncture
1) Confidence 0.67 Published 1993 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 8313180 Disease Relevance 0.25 Pain Relevance 0.59
Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients.
Positive_regulation (/) of Gene_expression (levels) of CSF in CSF associated with neuromyelitis optica and disease
2) Confidence 0.49 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20128675 Disease Relevance 1.16 Pain Relevance 0.14
Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS
Positive_regulation (Elevated) of Gene_expression (levels) of CSF associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.49 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1187874 Disease Relevance 0.20 Pain Relevance 0.04
Data from the one patient with Pick's disease demonstrates that reduced CSF levels of neurophysins and hormones is not confined to Alzheimer-type dementia.
Neg (not) Positive_regulation (confined) of Gene_expression (levels) of CSF in CSF associated with dementia and disease
4) Confidence 0.45 Published 1992 Journal Neurobiol. Aging Section Abstract Doc Link 1522943 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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