INT108555

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.91
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HK2) mitochondrion (HK2) small molecule metabolic process (HK2)
carbohydrate metabolic process (HK2) kinase activity (HK2) transmembrane transport (HK2)
Anatomy Link Frequency
HK-2 2
HK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 20 99.98 Very High Very High Very High
cINOD 7 99.54 Very High Very High Very High
COX2 2 90.12 High High
lidocaine 2 79.96 Quite High
sodium channel 4 69.60 Quite High
tetrodotoxin 2 67.28 Quite High
Dopamine 2 52.52 Quite High
Chronic pancreatitis 3 44.56 Quite Low
potassium channel 4 14.68 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 50 100.00 Very High Very High Very High
Death 32 99.96 Very High Very High Very High
Apoptosis 26 99.76 Very High Very High Very High
Pancreatic Cancer 81 99.60 Very High Very High Very High
Lifespan 72 93.60 High High
Aging 72 89.76 High High
Reprotox - General 1 3 88.44 High High
Cancer 78 83.08 Quite High
INFLAMMATION 4 81.24 Quite High
Acute Renal Failure 2 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All 3 local anesthetics caused concentration-dependent cell death, induced HK-2 cell apoptosis and potentiated TNF-alpha induced apoptosis.
Positive_regulation (induced) of HK-2 in HK-2 associated with apoptosis, death and local anesthetic
1) Confidence 0.29 Published 2003 Journal Am. J. Nephrol. Section Abstract Doc Link 12586958 Disease Relevance 1.08 Pain Relevance 0.91
Local anesthetics induced HK-2 cell apoptosis by activation of caspases 3, 6, 7, 8 and 9.
Positive_regulation (induced) of HK-2 in HK-2 associated with apoptosis and local anesthetic
2) Confidence 0.29 Published 2003 Journal Am. J. Nephrol. Section Abstract Doc Link 12586958 Disease Relevance 1.20 Pain Relevance 0.99
In mutant flies the preference for sleep at night either increased (Hk1 and Hk2) or remained constant (HkY), while in all wild-type siblings it decreased between young and middle age, and remained constant afterwards.
Positive_regulation (increased) of Hk2
3) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2871268 Disease Relevance 0.13 Pain Relevance 0
Thus, we always compared outcrossed males that inherited the Hk allele (the strong hypomorph Hk1 and HkY or the weak hypomorph Hk2) to siblings that inherited a wild-type allele, because siblings have a common genetic background and an equal chance of inheriting modifiers.
Positive_regulation (inherited) of Hk2
4) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2871268 Disease Relevance 0.52 Pain Relevance 0.03
These results marked the first evidence that DEC1 and hexokinase II were hypoxia-induced in human pancreatic cancer and represented the initial report of hypoxic-regulation of GPI/NLK/AMF in any human system [44].
Positive_regulation (induced) of hexokinase II associated with hypoxia and pancreatic cancer
5) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.58 Pain Relevance 0
We demonstrated that both NSAIDs repressed AR-mediated activation of prostate-specific antigen and hK2 promoter activity as well as AR protein expression.
Positive_regulation (activation) of hK2 associated with cinod
6) Confidence 0.00 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.40 Pain Relevance 0.69

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox