INT108559

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 30.07
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
B cells 1
brain 1
microglia 1
Pol (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 26 100.00 Very High Very High Very High
imagery 27 96.72 Very High Very High Very High
chemokine 15 92.28 High High
cytokine 132 91.72 High High
addiction 44 84.56 Quite High
Migraine 3 75.00 Quite High
aspirin 1 69.36 Quite High
cva 6 60.00 Quite High
Inflammation 90 58.60 Quite High
anesthesia 49 44.24 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1102 100.00 Very High Very High Very High
Cytomegalovirus Infection 854 100.00 Very High Very High Very High
Multiple Sclerosis 28 100.00 Very High Very High Very High
Contagious Ecthyma 13 99.62 Very High Very High Very High
Cancer 288 99.60 Very High Very High Very High
Pox Virus Infection 100 99.58 Very High Very High Very High
Targeted Disruption 559 99.48 Very High Very High Very High
Sprains And Strains 220 99.12 Very High Very High Very High
Infection 991 99.06 Very High Very High Very High
Epstein-barr Virus 18 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another group of putative MuERVs, defective in their genome structures, had intact coding potentials for gag, pol, and/or env polypeptides and it is likely that changes in the expression of these individual proteins affect the host cells' normal physiology, such as overexpression of syncytin in the brain of multiple sclerosis patients.
Gene_expression (polypeptides) of pol in brain associated with multiple sclerosis
1) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.52 Pain Relevance 0.05
Some of those defective MuERVs had intact ORFs for gag, pol, and/or env polypeptides.
Gene_expression (polypeptides) of pol
2) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.15 Pain Relevance 0
Compared with Pol III promoters, Pol II promoter-directed synthesis of shRNAs can be advantageous for transgenic RNAi.
Gene_expression (synthesis) of Pol associated with targeted disruption
3) Confidence 0.41 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.59 Pain Relevance 0
In contrast, the HCMV laboratory strain AD-169, which does not replicate in EC and expresses a minimal level of pol, did not induce renin expression (Fig. 7C and D).
Gene_expression (expresses) of pol associated with cytomegalovirus infection and sprains and strains
4) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.88 Pain Relevance 0.06
RT-PCR examining expression of pp65, IE1, IE2, and pol mRNA in infected cells
Gene_expression (expression) of pol
5) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.07 Pain Relevance 0
Our data show that, compared to AD169, HCMV clinical isolates infected EC and expressed two key genes that were important for CMV replication, ie2 and pol.
Gene_expression (expressed) of pol associated with cytomegalovirus infection
6) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.15 Pain Relevance 0
Furthermore, in a multi time-point CMV infection kinetic study, we defined that HCMV clinical isolates infected EC in a persistent infection manner, in which the copies of pol gene were quantitatively detected in cell culture supernatant, in contrast to the copy numbers of pol expression from AD169 known to be unable to replicate in EC (Fig.
Gene_expression (expression) of pol associated with cytomegalovirus infection and infection
7) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.12 Pain Relevance 0
Thus far, only RNA polymerase III (Pol III)–expressed short hairpin RNA (shRNA) has been used to make shRNA-expressing transgenic mice.
Gene_expression (expressed) of Pol associated with targeted disruption
8) Confidence 0.32 Published 2006 Journal PLoS Genet Section Abstract Doc Link PMC1358942 Disease Relevance 0.48 Pain Relevance 0
These results demonstrate that Pol II–mediated expression of shRNA in transgenic mice can be used to investigate gene functions in mammals.
Gene_expression (expression) of Pol associated with targeted disruption
9) Confidence 0.32 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.74 Pain Relevance 0
These investigators used RNA polymerase II (Pol II) to express a short hairpin RNA (shRNA) that triggers destruction of the mRNA-encoding Mn superoxide dismutase (SOD2) in transgenic mice.
Gene_expression (express) of Pol associated with targeted disruption
10) Confidence 0.32 Published 2006 Journal PLoS Genet Section Abstract Doc Link PMC1358942 Disease Relevance 0.99 Pain Relevance 0
Therefore, strategies using Pol II–directed synthesis of shRNA mimic the natural miRNA synthesis and could be an efficient RNAi strategy in vivo.
Gene_expression (synthesis) of Pol
11) Confidence 0.32 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.52 Pain Relevance 0
Thus, the Pol II–directed synthesis of shRNA can be an alternative to gene knockout technology for reverse genetics in mammals.
Gene_expression (synthesis) of Pol associated with targeted disruption
12) Confidence 0.32 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.75 Pain Relevance 0
With the advent of Pol III promoter-directed synthesis of shRNAs, several groups engineered transgenic mice using Pol III–shRNA constructs [18–23].
Gene_expression (synthesis) of Pol associated with targeted disruption
13) Confidence 0.32 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.26 Pain Relevance 0
The pol gene expresses a complex of enzymes that are involved in particle maturation (protease), DNA metabolism (reverse transcriptase) and proviral integration (integrase).
Gene_expression (expresses) of pol
14) Confidence 0.31 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.13 Pain Relevance 0
Multiple sclerosis-associated virus-related pol sequences found both in multiple sclerosis and healthy donors are more frequently expressed in multiple sclerosis patients.
Gene_expression (expressed) of pol associated with multiple sclerosis
15) Confidence 0.28 Published 2003 Journal J. Neurovirol. Section Title Doc Link 12587074 Disease Relevance 2.01 Pain Relevance 0.64
Serial, ten-fold dilutions of full-length XMRV(VP62) plasmid (kindly provided by Robert Silverman) in a background of human DNA (PBMC or whole blood) showed that the nested gag and pol PCR tests each detected 10 XMRV copies in different experiments on subsequent days (34/34 (100%) and 32/34 (94.1%), respectively).
Gene_expression (detected) of pol in blood
16) Confidence 0.24 Published 2010 Journal Retrovirology Section Body Doc Link PMC2908559 Disease Relevance 0.34 Pain Relevance 0
In order to minimise the risk of RCR production, an improved vector system was designed by segregating the gag/pol and env genes present on the packaging construct, onto discrete expression units, Figure 4.
Gene_expression (present) of pol
17) Confidence 0.24 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0 Pain Relevance 0
Subsequently, these putative MuERV sequences were subjected to ORF analyses for gag, pol, and env polypeptides using reference retroviral sequences encoding intact polypeptides (GenBank accession number: AF033811, J02255, DQ241301, S80082, M17327, and AAO37285).


Gene_expression (polypeptides) of pol associated with contagious ecthyma
18) Confidence 0.20 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.18 Pain Relevance 0
Cells infected with this virus express all of the viral gene products except Pol and release immature virions that cannot complete subsequent rounds of infection [25],[26].
Neg (except) Gene_expression (express) of Pol associated with infection
19) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2621341 Disease Relevance 0.48 Pain Relevance 0
In a phase IIb proof-of-concept trial, nearly 3000 participants were immunized at 0, 1 and 6 months with rAd5 vectors expressing HIV-1 clade B gag, pol and nef genes, or a placebo control [18],[19].
Gene_expression (expressing) of pol associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2621341 Disease Relevance 0.66 Pain Relevance 0

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