INT108579

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 3.47
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
skin 6
IB4 2
facial nerve 1
nucleus 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 9 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
unmyelinated 4 99.76 Very High Very High Very High
dorsal root ganglion 30 94.64 High High
transdermal 325 93.64 High High
alcohol 143 93.04 High High
Neuropathic pain 7 91.92 High High
qutenza 5 91.68 High High
Disease Link Frequency Relevance Heat
Adhesions 3 99.62 Very High Very High Very High
Facial Nerve Injuries 6 98.28 Very High Very High Very High
Atherosclerosis 7 96.00 Very High Very High Very High
Ganglion Cysts 31 94.64 High High
Neuropathic Pain 8 91.92 High High
Nervous System Injury 8 87.60 High High
INFLAMMATION 41 83.56 Quite High
Nociception 7 82.76 Quite High
Hyperalgesia 12 82.16 Quite High
Pain 10 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are in agreement with the previous investigations by Wahid et al (2008).39 When the values of the coefficients for “t (time)” were compared, the in vitro release of NF from NF-11 (x coefficient was 0.017) and in vitro skin permeation for NF-11 (x coefficient 0.0061) was found to be marginally higher in comparison to the other selected transdermal plasters.


Localization (release) of NF-11 in skin associated with transdermal
1) Confidence 0.72 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.08
The results are in agreement with the previous investigations by Wahid et al (2008).39 When the values of the coefficients for “t (time)” were compared, the in vitro release of NF from NF-11 (x coefficient was 0.017) and in vitro skin permeation for NF-11 (x coefficient 0.0061) was found to be marginally higher in comparison to the other selected transdermal plasters.


Localization (release) of NF in skin associated with transdermal
2) Confidence 0.72 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.08
Higher concentration of glycerin (above 0.1 g/100 mL) produced slight increase in release of NF but the films were found to be tacky and difficult to peel off from the surface.
Localization (release) of NF
3) Confidence 0.72 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.10
As indicated by the coefficients of “square root t (time)” values the in vitro release of NF from NF-11 was higher (x coefficient was 13.75) whereas in vitro skin permeation was higher for NF-10 (4.857).
Localization (release) of NF-11 in skin
4) Confidence 0.72 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.11
As indicated by the coefficients of “square root t (time)” values the in vitro release of NF from NF-11 was higher (x coefficient was 13.75) whereas in vitro skin permeation was higher for NF-10 (4.857).
Localization (release) of NF in skin
5) Confidence 0.72 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.11
The findings of this study are suggestive of the superiority of NF-10, NF-11, and NF-12 in terms of physical properties, in vitro release profile as well as skin permeation profiles.
Localization (release) of NF-12 in skin
6) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0
The 62.66% release of drug from NF-11 was somewhat comparable with the 54.27% from NF-10, when DMSO concentration was increased from 2.0 g/100 mL to 3.0 g/100 mL.
Localization (release) of NF-11
7) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.06
The findings of this study are suggestive of the superiority of NF-10, NF-11, and NF-12 in terms of physical properties, in vitro release profile as well as skin permeation profiles.
Localization (release) of NF-11 in skin
8) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0
The comparative release of NF from various formulations was shown in Figures 3 and 4.


Localization (release) of NF
9) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.11
The comparative release of NF from various selected formulations was shown in Figure 5.


Localization (release) of NF
10) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.11
As the concentration of DMSO was increased (NF-9 to NF-11), the release of NF increased from 43.12% to 62.66% at 24 hours (Fig. 4).
Localization (release) of NF
11) Confidence 0.63 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.07
PVP acts as nucleating agent that retards the crystallization of NF and hence enhances the release of the drug from matrix by sustaining it in an amorphous form.
Localization (crystallization) of NF
12) Confidence 0.59 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0
Although the maximum release was found with formulation NF-11 (62.66%), which contained 3% DMSO, but NF-10 (54.27% release) was regarded as the best formulation based on the physicochemical properties.
Localization (release) of NF
13) Confidence 0.55 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.05
Duplicate series of NF and GFAP immunoreactive sections from the facial nerve injury were stained by cresyl violet (CV) for interalia visualization of Nissl substance.
Localization (series) of NF in facial nerve associated with facial nerve injuries
14) Confidence 0.18 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.16 Pain Relevance 0
For example, cell adhesion molecules such as neurofascin (NF)-186 localise to the AIS by binding to the scaffolding protein ankyrin-G, an interaction which depends upon a C-terminus FIGQY domain [82], [83], [84].
Localization (localise) of neurofascin associated with adhesions
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966437 Disease Relevance 0.10 Pain Relevance 0.24
In multiple labelling experiments, c-Fos was examined for co-localization with nitric oxide synthase (NOS), vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), enkephalin (ENK), gastrin-releasing peptide (GRP), substance P (SP), calbindin D-28k (CALB) and neurofilament 145 (NF 145).
Spec (examined) Localization (localization) of NF 145 associated with neuropeptide, enkephalin and substance p
16) Confidence 0.06 Published 2003 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12588467 Disease Relevance 0 Pain Relevance 0.78
Moreover, the blood levels of TNF- alpha, IL-1 beta, and CRP and the translocation of NF- kappaB to the nucleus were significantly suppressed in paeonol groups, as was the inhibition of lipid peroxidation.
Localization (translocation) of NF in nucleus
17) Confidence 0.05 Published 2009 Journal Planta Med. Section Abstract Doc Link 19003727 Disease Relevance 0.85 Pain Relevance 0.29
Double labeling analysis of CysLT2 with NF-200, calcitonin gene-related peptide (CGRP), isolectin B4 (IB4), transient receptor potential vanilloid subfamily 1 (TRPV1) and P2X3 receptor revealed that many CysLT2-labeled neurons were localized with unmyelinated and non-peptidergic neurons, and interestingly, CysLT2 mRNA heavily co-localized with TRPV1 and P2X3-positive neurons.
Localization (localized) of NF-200 in IB4 associated with unmyelinated and calcitonin gene-related peptide
18) Confidence 0.03 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2949724 Disease Relevance 1.15 Pain Relevance 0.95
Co-localisation of TRPML3 with CGRP, NF200 and IB4 staining confirmed a broad subtype distribution.
Localization (localisation) of NF200 in IB4
19) Confidence 0.01 Published 2009 Journal Pain Section Abstract Doc Link 19446956 Disease Relevance 1.20 Pain Relevance 0.85

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox