INT10858

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Context Info
Confidence 0.02
First Reported 1989
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 5.28
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Apol7b) cellular_component (Apol7b) biological_process (Apol7b)
Apol7b (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 1 84.08 Quite High
Angina 1 74.56 Quite High
Pain 3 66.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 32 100.00 Very High Very High Very High
Hyperlipidemia 5 99.06 Very High Very High Very High
Disease Progression 1 88.52 High High
Brain Hemorrhage 1 87.08 High High
Cv Unclassified Under Development 1 84.76 Quite High
Abdominal Pain 1 84.08 Quite High
Coronary Artery Disease 1 83.16 Quite High
Exanthema 1 82.80 Quite High
Myalgia 3 81.92 Quite High
Disorders Of Creatine Metabolism 2 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with L-thyroxine caused a significant increase in HDL-cholesterol from 1.29 +/- 0.34 to 1.45 +/- 0.49 mmol/L (P less than 0.05) and a significant decrease in cholesterol from 8.0 +/- 1.3 to 7.2 +/- 1.1 mmol/L (P less than 0.01) and apolipoprotein B from 1.23 +/- 0.20 to 1.04 +/- 0.16 g/l (P less than 0.001).
Negative_regulation (decrease) of apolipoprotein B associated with disorder of lipid metabolism
1) Confidence 0.02 Published 1989 Journal Eur J Vasc Surg Section Abstract Doc Link 2714458 Disease Relevance 1.33 Pain Relevance 0.13
The addition of acipimox to lovastatin for an additional 12 weeks further reduced serum total cholesterol, triglyceride, LDL cholesterol, and apolipoprotein B, but this additional decrease was not statistically significant.
Negative_regulation (reduced) of apolipoprotein B associated with disorder of lipid metabolism
2) Confidence 0.02 Published 1998 Journal J Clin Pharmacol Section Abstract Doc Link 9807971 Disease Relevance 1.36 Pain Relevance 0.07
After 12 weeks of treatment with lovastatin alone, improvement was observed in total cholesterol (21% reduction), triglyceride (32% reduction), low-density lipoprotein (LDL) cholesterol (5.5% reduction), HDL cholesterol (11.6% elevation), apolipoprotein A-I (4.6% elevation), and apolipoprotein B (20.5% reduction).
Negative_regulation (reduction) of apolipoprotein B associated with disorder of lipid metabolism
3) Confidence 0.02 Published 1998 Journal J Clin Pharmacol Section Abstract Doc Link 9807971 Disease Relevance 1.34 Pain Relevance 0.05
In type IIa and IIb HLP low density lipoprotein (LDL) cholesterol and apolipoprotein B levels decreased while in type IV increased.
Negative_regulation (decreased) of apolipoprotein B associated with hyperlipidemia and disorder of lipid metabolism
4) Confidence 0.01 Published 1992 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 1523145 Disease Relevance 0.97 Pain Relevance 0.08

General Comments

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