INT108585

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 28.37
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
synovial cells 4
adipose tissue 4
chondrocytes 2
fibroblasts 2
nucleus 2
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 24 100.00 Very High Very High Very High
Kinase C 5 99.62 Very High Very High Very High
agonist 36 99.52 Very High Very High Very High
cINOD 30 97.86 Very High Very High Very High
Inflammation 461 97.48 Very High Very High Very High
fibrosis 82 97.44 Very High Very High Very High
dexamethasone 196 96.60 Very High Very High Very High
COX-2 inhibitor 7 85.80 High High
Inflammatory response 14 80.04 Quite High
Dismenorea 3 78.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 931 100.00 Very High Very High Very High
Cancer 326 99.68 Very High Very High Very High
Obesity 284 99.28 Very High Very High Very High
Disease 268 99.16 Very High Very High Very High
Pancreatic Cancer 45 98.96 Very High Very High Very High
Lung Cancer 15 98.72 Very High Very High Very High
Prostate Cancer 11 98.56 Very High Very High Very High
Death 120 97.72 Very High Very High Very High
INFLAMMATION 484 97.48 Very High Very High Very High
Pulmonary Fibrosis 63 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Positive_regulation (increase) of Gene_expression (expression) of caspase-3 in synovial cells associated with apoptosis
1) Confidence 0.70 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.03 Pain Relevance 0.27
These NO-NSAIDs increased caspase-3 expression.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3
2) Confidence 0.69 Published 2004 Journal J. Urol. Section Body Doc Link 15201807 Disease Relevance 0.06 Pain Relevance 0
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Positive_regulation (increase) of Gene_expression (expression) of CASP3 in synovial cells associated with apoptosis
3) Confidence 0.50 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.03 Pain Relevance 0.27
Changes in apoptosis were examined using TdT-mediated dUTP-biotin nick end-labeling assay and by the immunoexpression of activated caspase-3 in tissues after GnRHa therapy.
Positive_regulation (activated) of Gene_expression (immunoexpression) of caspase-3
4) Confidence 0.49 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20008888 Disease Relevance 0.29 Pain Relevance 0
We detected active caspase-3 in all biopsy specimens, early or late, with or without amifostine, even in pre-radiation biopsies.
Positive_regulation (detected) of Gene_expression (detected) of caspase-3
5) Confidence 0.49 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2903531 Disease Relevance 1.00 Pain Relevance 0.03
The expression of p53, p21, bax and caspase-3 increased in Tan-I-treated cells.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3
6) Confidence 0.49 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18949381 Disease Relevance 1.01 Pain Relevance 0.08
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Positive_regulation (increased) of Gene_expression (expression) of CASP3 associated with apoptosis
7) Confidence 0.41 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
, or IL-6, nor increases in proapoptotic CASP3 or Bax expressions were observed in adipose tissue of such subjects.
Neg (nor) Positive_regulation (increases) of Gene_expression (expressions) of CASP3 in adipose tissue associated with obesity
8) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.60 Pain Relevance 0.12
, or IL-6, nor increases in proapoptotic CASP3 or Bax expressions were observed in adipose tissue of such subjects.
Neg (nor) Positive_regulation (increases) of Gene_expression (expressions) of CASP3 in adipose tissue associated with obesity
9) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.60 Pain Relevance 0.12
Caspase-3 activation as determined by generation of caspase-3-p20 fragment
Spec (determined) Positive_regulation (generation) of Spec (determined) Gene_expression (generation) of caspase-3-p20
10) Confidence 0.30 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0 Pain Relevance 0.26
Western blot analyses also detected overexpression of calpain and caspase-3, which cleaved 270 kD ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of caspase-3
11) Confidence 0.28 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC544397 Disease Relevance 1.27 Pain Relevance 0.36
But there was a significant increase (P = 0.001) in production of active 20 kD caspase-3 fragment in cells treated with TMZ, compared to CTL cells.
Positive_regulation (increase) of Gene_expression (production) of 20 kD caspase-3 fragment
12) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.19 Pain Relevance 0.31
Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3 associated with prostate cancer and apoptosis
13) Confidence 0.25 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.72 Pain Relevance 0.08
Ectopic expression of human caspase-3 significantly potentiated the cytotoxic effect of acetaminophen and promoted the release of cytochrome c into the cytosol of treated cells suggesting a direct role for caspase-3 in acetaminophen-induced apoptosis.
Positive_regulation (potentiated) of Gene_expression (expression) of caspase-3 associated with paracetamol and apoptosis
14) Confidence 0.20 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.73 Pain Relevance 0.72
Ectopic expression of human caspase-3 significantly potentiated the cytotoxic effect of acetaminophen and promoted the release of cytochrome c into the cytosol of treated cells suggesting a direct role for caspase-3 in acetaminophen-induced apoptosis.
Positive_regulation (promoted) of Gene_expression (expression) of caspase-3 associated with paracetamol and apoptosis
15) Confidence 0.20 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.73 Pain Relevance 0.74
Quantitation of the relative fluorescence intensity of caspase activation revealed a significant 8–10 fold enhancement of caspase-3 activity in the PS-1 (M146L) AD fibroblasts between 2 and 7 hr after oxidative stress (Figure 12L).
Positive_regulation (enhancement) of Gene_expression (activity) of caspase-3 in fibroblasts associated with stress and disease
16) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.36 Pain Relevance 0
Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non-small cell lung cancer cells.
Positive_regulation (increasing) of Gene_expression (expression) of caspase-3 in lung associated with lung cancer, cancer and apoptosis
17) Confidence 0.16 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 1.14 Pain Relevance 0.06
Effect of PTL at various concentrations on caspase-9 and caspase-3 expression
Positive_regulation (on) of Gene_expression (expression) of caspase-3
18) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.52 Pain Relevance 0
Quantitative analysis of the activation of caspase-3 expressions
Positive_regulation (activation) of Gene_expression (expressions) of caspase-3
19) Confidence 0.13 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630851 Disease Relevance 0.07 Pain Relevance 0
Determination of the activation of caspase-3 expressions
Positive_regulation (activation) of Gene_expression (expressions) of caspase-3
20) Confidence 0.13 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630851 Disease Relevance 0.30 Pain Relevance 0

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