INT108588

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 4
Speculated 6
Reported most in Abstract
Documents 126
Total Number 134
Disease Relevance 84.49
Pain Relevance 16.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
cleavage 7
chondrocytes 5
nucleus 3
monocytes 3
adipose tissue 3
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1204 100.00 Very High Very High Very High
cytokine 506 100.00 Very High Very High Very High
rheumatoid arthritis 448 99.60 Very High Very High Very High
dexamethasone 520 99.54 Very High Very High Very High
COX-2 inhibitor 28 99.46 Very High Very High Very High
Paracetamol 26 99.24 Very High Very High Very High
Kinase C 25 98.94 Very High Very High Very High
agonist 91 98.80 Very High Very High Very High
qutenza 28 98.54 Very High Very High Very High
cINOD 79 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 3589 100.00 Very High Very High Very High
INFLAMMATION 1289 100.00 Very High Very High Very High
Obesity 485 99.98 Very High Very High Very High
Death 600 99.68 Very High Very High Very High
Rheumatoid Arthritis 457 99.60 Very High Very High Very High
Breast Cancer 61 99.46 Very High Very High Very High
Stress 358 99.44 Very High Very High Very High
Cancer 1021 99.38 Very High Very High Very High
Periodontitis 225 99.28 Very High Very High Very High
Disease 729 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Gene_expression (expression) of CASP3 in synovial cells associated with apoptosis
1) Confidence 0.78 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.01 Pain Relevance 0.27
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Gene_expression (expression) of caspase-3 in synovial cells associated with apoptosis
2) Confidence 0.78 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.02 Pain Relevance 0.27
Caspase-3 expression was also examined in treated cell types.
Spec (examined) Gene_expression (expression) of Caspase-3
3) Confidence 0.77 Published 2004 Journal J. Urol. Section Body Doc Link 15201807 Disease Relevance 0.07 Pain Relevance 0
These NO-NSAIDs increased caspase-3 expression.
Gene_expression (expression) of caspase-3
4) Confidence 0.77 Published 2004 Journal J. Urol. Section Body Doc Link 15201807 Disease Relevance 0.06 Pain Relevance 0
The expression of p53, p21, bax and caspase-3 increased in Tan-I-treated cells.
Gene_expression (expression) of caspase-3
5) Confidence 0.75 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18949381 Disease Relevance 1.00 Pain Relevance 0.08
We have further extended our histopathologic study by examining the immunohistochemical expression of active caspase-3.
Gene_expression (expression) of caspase-3
6) Confidence 0.75 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2903531 Disease Relevance 0.96 Pain Relevance 0.03
We detected active caspase-3 in all biopsy specimens, early or late, with or without amifostine, even in pre-radiation biopsies.
Gene_expression (detected) of caspase-3
7) Confidence 0.75 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2903531 Disease Relevance 1.00 Pain Relevance 0.03
Therefore, the aim of the present study was: 1) to analyse the expression of COX-2 in the biopsies obtained from BE; 2) to compare the effect of NO-ASA with that of ASA on proliferation rate in Barretts adenocarcinoma cell line (OE-33 cells); 3) to determine the effect of both compounds on the apoptosis rate using FACS analysis and expression of 32-kDa procaspase-3 and active proapoptotic 20-kDa caspase-3 in OE-33 cell line.
Gene_expression (expression) of procaspase-3 associated with adenocarcinoma, aspirin and apoptosis
8) Confidence 0.75 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17244951 Disease Relevance 1.06 Pain Relevance 0.71
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Gene_expression (expression) of procaspase-3 in cleavage
9) Confidence 0.75 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.86 Pain Relevance 0.10
Changes in apoptosis were examined using TdT-mediated dUTP-biotin nick end-labeling assay and by the immunoexpression of activated caspase-3 in tissues after GnRHa therapy.
Gene_expression (immunoexpression) of caspase-3
10) Confidence 0.65 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20008888 Disease Relevance 0.29 Pain Relevance 0
Apoptotic events were assessed by flow-cytometrical detection of surface phosphatidylserine and nuclear fragmentation, as well as Fas, Bcl-2, and Caspase-3 activity in PBLs gated on a light-scatter basis.
Gene_expression (detection) of Caspase-3 in PBLs associated with apoptosis
11) Confidence 0.65 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192531 Disease Relevance 0.65 Pain Relevance 0.83
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Gene_expression (expression) of CASP3 associated with apoptosis
12) Confidence 0.63 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
In this study, we compared the effect of capsaicin and its docosahexaenoic acid (DHA, C22:6) analog (we named as dohevanil) on human breast cancer MCF-7 cells, which do not express caspase-3.
Neg (not) Gene_expression (express) of caspase-3 in MCF-7 associated with qutenza and breast cancer
13) Confidence 0.62 Published 2006 Journal Life Sci. Section Abstract Doc Link 16260002 Disease Relevance 0.42 Pain Relevance 0.47
It was found that capsaicin induces dose-dependent growth inhibition of MCF-7 cells, which does not express caspase-3.
Neg (not) Gene_expression (express) of caspase-3 in MCF-7 associated with qutenza
14) Confidence 0.59 Published 2009 Journal Oncol. Rep. Section Abstract Doc Link 19212624 Disease Relevance 0.48 Pain Relevance 0.53
Fas ligand cytokine levels correlated with expression of both caspase-3 and -2, suggesting a link in the apoptotic "death cascade."
Gene_expression (expression) of caspase-3 associated with apoptosis, death and cytokine
15) Confidence 0.59 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15148056 Disease Relevance 0.92 Pain Relevance 0.11
Therefore, the aim of the present study was: 1) to analyse the expression of COX-2 in the biopsies obtained from BE; 2) to compare the effect of NO-ASA with that of ASA on proliferation rate in Barretts adenocarcinoma cell line (OE-33 cells); 3) to determine the effect of both compounds on the apoptosis rate using FACS analysis and expression of 32-kDa procaspase-3 and active proapoptotic 20-kDa caspase-3 in OE-33 cell line.
Gene_expression (expression) of caspase-3 associated with adenocarcinoma, aspirin and apoptosis
16) Confidence 0.58 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17244951 Disease Relevance 1.06 Pain Relevance 0.71
, or IL-6, nor increases in proapoptotic CASP3 or Bax expressions were observed in adipose tissue of such subjects.
Gene_expression (expressions) of CASP3 in adipose tissue associated with obesity
17) Confidence 0.55 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.53 Pain Relevance 0.12
Caspase-3 activation was detected by Western blotting, fluorometric assay of DEVD-AMC cleavage, and flow cytometry with carboxyfluorescein (FAM) labeled caspase inhibitor.
Gene_expression (detected) of Caspase-3 in cleavage
18) Confidence 0.54 Published 2008 Journal Chirality Section Abstract Doc Link 18092300 Disease Relevance 1.04 Pain Relevance 0.44
Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells.
Gene_expression (activation) of caspase-3 associated with leukemia and apoptosis
19) Confidence 0.51 Published 2009 Journal Biomed. Pharmacother. Section Title Doc Link 18804340 Disease Relevance 0.73 Pain Relevance 0.04
The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DJm), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP).
Gene_expression (activation) of caspase-3 in poly
20) Confidence 0.51 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.81 Pain Relevance 0.13

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