INT108589

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 10.52
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
chondrocytes 2
SW480 2
monocyte 2
poly 2
cleavage 2
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 13 100.00 Very High Very High Very High
dexamethasone 64 99.98 Very High Very High Very High
COX-2 inhibitor 1 99.76 Very High Very High Very High
cINOD 10 98.88 Very High Very High Very High
Inflammation 138 91.52 High High
COX2 1 83.08 Quite High
corticosteroid 1 81.28 Quite High
Inflammatory response 8 77.88 Quite High
cytokine 40 75.68 Quite High
Osteoarthritis 24 75.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 399 100.00 Very High Very High Very High
Periodontitis 50 99.28 Very High Very High Very High
Death 76 98.20 Very High Very High Very High
Disorder Of Lipid Metabolism 5 95.36 Very High Very High Very High
Familial Adenomatous Polyposis 5 94.48 High High
Cancer 72 93.08 High High
Hyperglycemia 38 92.56 High High
Pancreatic Cancer 21 91.92 High High
Cervical Cancer 5 91.72 High High
INFLAMMATION 150 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Negative_regulation (reduction) of Gene_expression (expression) of procaspase-3 in cleavage
1) Confidence 0.57 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.86 Pain Relevance 0.10
The results of this study demonstrate that platycodon D mediates ROS production, and that this mediation is followed by a decrease in mitochondrial membrane potential (MMP, DJm), activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase (PARP).
Negative_regulation (decrease) of Gene_expression (activation) of caspase-3 in poly
2) Confidence 0.32 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.83 Pain Relevance 0.13
A pretreatment with DXM decreased calpain and caspase-3 activities in U87MG cells.
Negative_regulation (decreased) of Gene_expression (activities) of caspase-3 associated with dexamethasone
3) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.83 Pain Relevance 0.28
Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta-induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes.
Negative_regulation (inhibited) of Gene_expression (activation) of caspase-3 in chondrocytes associated with apoptosis
4) Confidence 0.11 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.87 Pain Relevance 0.29
Following caspase-9 activation, Pro-caspase-3 expression was downregulated significantly.
Negative_regulation (downregulated) of Gene_expression (expression) of Pro-caspase-3
5) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.78 Pain Relevance 0
Our study compared clinical findings and expression of p53, Bcl-2 and caspase-3 in patients with GAP versus healthy controls.
Negative_regulation (compared) of Spec (findings) Gene_expression (expression) of caspase-3 associated with periodontitis
6) Confidence 0.09 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.00 Pain Relevance 0.08
We found no significant differences between these groups with respect to overall frequency of caspase-3 expression or frequencies of different grades of expression of p53.
Negative_regulation (frequency) of Gene_expression (expression) of caspase-3
7) Confidence 0.09 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 0.93 Pain Relevance 0.07
In addition, introduction of constitutively active Akt blocks caspase-3 activation and rescues cells from apoptotic death upon butyrate treatment (Fig. 4).
Negative_regulation (blocks) of Gene_expression (introduction) of caspase-3 associated with apoptosis and death
8) Confidence 0.09 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.98 Pain Relevance 0
Pro-caspase-3 production remained unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (production) of Pro-caspase-3
9) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.66 Pain Relevance 0.17
Inhibition of COX-2 with a selective COX-2 inhibitor NS398 also inhibited PGE2 production, caspase-3 activity and apoptosis in HUVECs treated with high glucose levels.
Negative_regulation (inhibited) of Gene_expression (production) of caspase-3 in PGE2 associated with cox-2 inhibitor and apoptosis
10) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.03 Pain Relevance 0.09
Correlation between monocyte caspase-3 activity and ex vivo production of TNF?
Negative_regulation (Correlation) of Gene_expression (activity) of caspase-3 in monocyte
11) Confidence 0.04 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1397846 Disease Relevance 0.24 Pain Relevance 0.10
A negative correlation was detected between caspase-3 activity and ex vivo release of TNF?
Negative_regulation (detected) of Gene_expression (activity) of caspase-3
12) Confidence 0.04 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1397846 Disease Relevance 0.07 Pain Relevance 0
NSAIDs also inhibited some of the apoptotic signaling that is downstream of p38 kinase and PKC, such as NFkappaB activation, p53 accumulation, and caspase-3 activation.
Negative_regulation (downstream) of Gene_expression (activation) of caspase-3 associated with kinase c, cinod and apoptosis
13) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12588866 Disease Relevance 0.94 Pain Relevance 0.76
Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells.
Negative_regulation (decreasing) of Gene_expression (expression) of pro-caspase 3 in SW480
14) Confidence 0.01 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16382042 Disease Relevance 0.50 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox