INT108601

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 6 98.28 Very High Very High Very High
Inflammation 32 96.00 Very High Very High Very High
Peripheral sensitization 3 86.96 High High
opioid receptor 110 86.16 High High
qutenza 70 83.44 Quite High
Morphine 53 77.80 Quite High
Opioid 18 75.44 Quite High
nMDA receptor 1 75.20 Quite High
MU agonist 3 50.00 Quite Low
agonist 14 38.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 96.00 Very High Very High Very High
Nociception 11 89.44 High High
Neuropathic Pain 4 25.92 Quite Low
Inflammatory Pain 4 21.12 Low Low
Hyperalgesia 12 13.72 Low Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selective action of neurotrophins is achieved via restricted expression of high affinity trk receptors through which the neurotrophins act.
Negative_regulation (achieved) of Gene_expression (expression) of trk
1) Confidence 0.41 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589921 Disease Relevance 0.09 Pain Relevance 0.29
While the DRG culture conditions utilised in our study included NGF and may therefore represent increased expression of TRPV1 in trk-A-expressing fibres, our findings are nonetheless relevant as increased NGF levels occur physiologically during inflammation [55].
Spec (may) Negative_regulation (represent) of Gene_expression (expressing) of trk-A associated with inflammation
2) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.19 Pain Relevance 1.02

General Comments

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