INT108603

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) plasma membrane (NTRK2)
Anatomy Link Frequency
synapses 1
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 21 98.32 Very High Very High Very High
Dorsal horn 1 96.24 Very High Very High Very High
Neuropathic pain 1 90.88 High High
Inflammation 2 90.04 High High
c fibre 1 88.16 High High
spinal dorsal horn 1 84.20 Quite High
tetrodotoxin 3 77.20 Quite High
Hyperalgesia 1 76.80 Quite High
Peripheral nervous system 1 76.44 Quite High
Nerve growth factor 1 73.84 Quite High
Disease Link Frequency Relevance Heat
Disease 126 99.68 Very High Very High Very High
Nociception 3 98.94 Very High Very High Very High
Neuropathic Pain 1 90.88 High High
INFLAMMATION 3 90.04 High High
Hyperalgesia 2 76.80 Quite High
Diabetes Mellitus 15 69.88 Quite High
Death 1 67.36 Quite High
Depression 1 66.80 Quite High
Cardiovascular Disease 33 53.08 Quite High
Headache 1 47.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that functional inhibitory synapses develop in the absence of neural activity, and that activation of TrkB receptors by BDNF modulates inhibitory neurotransmission in Purkinje cells at both pre- and postsynaptic sites.
Positive_regulation (activation) of TrkB in synapses
1) Confidence 0.49 Published 2005 Journal Synapse Section Abstract Doc Link 15986361 Disease Relevance 0 Pain Relevance 0.22
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Positive_regulation (elevated) of TrkB associated with disease
2) Confidence 0.40 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.57
Stimulation of pre-synaptic nociceptive afferent fibres induces BDNF release and consequent activation of TrkB receptors leading to a post-synaptic excitability.
Positive_regulation (activation) of TrkB associated with nociception
3) Confidence 0.22 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589922 Disease Relevance 0.56 Pain Relevance 0.59

General Comments

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