INT108608

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.66
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
motoneurons 4
neuronal 2
nucleus 2
dorsal root ganglia 2
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 7 100.00 Very High Very High Very High
aspirin 2 99.72 Very High Very High Very High
Rostral ventrolateral medulla 55 99.56 Very High Very High Very High
nMDA receptor 2 99.12 Very High Very High Very High
Brush evoked pain 1 97.56 Very High Very High Very High
Spinal cord 2 97.48 Very High Very High Very High
Dorsal horn 1 97.00 Very High Very High Very High
Thermal hyperalgesia 1 96.68 Very High Very High Very High
medulla 12 96.60 Very High Very High Very High
Sumatriptan 2 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 66 98.68 Very High Very High Very High
Neuropathic Pain 2 97.56 Very High Very High Very High
Hyperalgesia 2 96.68 Very High Very High Very High
Injury 7 95.36 Very High Very High Very High
Nociception 1 80.08 Quite High
Cv Unclassified Under Development 2 66.28 Quite High
Myocardial Infarction 1 64.56 Quite High
Depression 2 32.80 Quite Low
Poisoning 7 27.88 Quite Low
Pressure Volume 2 Under Development 5 9.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase.
Positive_regulation (induced) of Positive_regulation (upregulation) of nitric oxide synthase
1) Confidence 0.49 Published 2008 Journal Shock Section Title Doc Link 18708911 Disease Relevance 0.23 Pain Relevance 0.21
Induction of neuronal nitric oxide synthase by sympathetic denervation is mediated via alpha 2-adrenoceptors in the jejunal myenteric plexus.
Positive_regulation (mediated) of Positive_regulation (Induction) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.44 Published 2003 Journal Brain Res. Section Title Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.49
Chronic compression of the dorsal root ganglia induced time-dependent upregulation of nNOS and NR2B subunits of N-methyl-D-aspartate receptor within the spinal cord dorsal horn ipsilateral to CCD.
Positive_regulation (induced) of Positive_regulation (upregulation) of nNOS in dorsal root ganglia associated with nmda receptor, dorsal horn and spinal cord
3) Confidence 0.44 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.35 Pain Relevance 0.87
Nitroglycerin-induced nNOS increase in rat trigeminal nucleus caudalis is inhibited by systemic administration of lysine acetylsalicylate but not of sumatriptan.
Positive_regulation (induced) of Positive_regulation (increase) of nNOS in nucleus associated with aspirin and sumatriptan
4) Confidence 0.41 Published 2004 Journal Cephalalgia Section Title Doc Link 15154853 Disease Relevance 0 Pain Relevance 0.40
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (-) of Positive_regulation (regulation) of nNOS in motoneurons
5) Confidence 0.38 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (up) of Positive_regulation (regulation) of nNOS in motoneurons
6) Confidence 0.38 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
Activation of MNK1/2 leads to upregulation of NOS I or PKG in RVLM during the pro-life phase
Positive_regulation (leads) of Positive_regulation (upregulation) of NOS I associated with rostral ventrolateral medulla
7) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.43 Pain Relevance 0.39
Gonadectomy causes nNOS up-regulation in LH cells and down-regulation in FS cells and this can be reversed by testosterone or oestradiol treatment (517–519).
Positive_regulation (causes) of Positive_regulation (regulation) of nNOS
8) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.15

General Comments

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