INT10863

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 45
Total Number 48
Disease Relevance 31.06
Pain Relevance 7.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) aging (Ldlr)
plasma membrane (Ldlr) lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
plasma 4
coronary artery 4
macrophages 2
heart 2
median nerve 1
Ldlr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 22 100.00 Very High Very High Very High
beta blocker 20 99.66 Very High Very High Very High
Migraine 11 99.64 Very High Very High Very High
Nerve growth factor 8 99.28 Very High Very High Very High
Angina 37 99.16 Very High Very High Very High
antagonist 27 99.04 Very High Very High Very High
Restless leg syndrome 23 98.28 Very High Very High Very High
Catecholamine 6 97.56 Very High Very High Very High
Bile 18 97.52 Very High Very High Very High
alcohol 15 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 300 100.00 Very High Very High Very High
Hyperlipidemia 110 100.00 Very High Very High Very High
Nicotine Addiction 28 100.00 Very High Very High Very High
Thyroid Disease 13 99.98 Very High Very High Very High
Hyperlipoproteinemia Type Ii 16 99.96 Very High Very High Very High
Pressure And Volume Under Development 49 99.92 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

27 99.92 Very High Very High Very High
Hypertension 20 99.72 Very High Very High Very High
Headache 12 99.64 Very High Very High Very High
Diabetes Mellitus 229 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To evaluate the effects of statins on coronary atherosclerotic plaque in patients with stable angina pectoris and type 2 diabetes with mild elevated low density lipoprotein-cholesterol (LDL-C).
Positive_regulation (elevated) of low density lipoprotein-cholesterol in plaque associated with stable angina pectoris, atherosclerotic plaque, angina and diabetes mellitus
1) Confidence 0.68 Published 2009 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Abstract Doc Link 19791470 Disease Relevance 0.52 Pain Relevance 0.10
Oxidation of low-density lipoprotein was induced either by copper ion in vitro after its isolation, or by ferrous ion in vivo in experimental rats under either normal or hypercholesterolemic situation and the beneficial effect of dietary capsaicin on the same was evaluated.
Positive_regulation (induced) of low-density lipoprotein associated with qutenza
2) Confidence 0.47 Published 2005 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16335782 Disease Relevance 0 Pain Relevance 0.42
RESULTS: Our results showed that in test group, serum glucose values decreased significantly (P < 0.05), but cholesterol, triglyceride, low density lipoprotein, alanine transaminase and aspartae transaminase increased significantly after use of T. polium (P < 0.05).
Positive_regulation (increased) of low density lipoprotein
3) Confidence 0.45 Published 2007 Journal Iran. Biomed. J. Section Body Doc Link 18051707 Disease Relevance 0.13 Pain Relevance 0
The calcium antagonist verapamil and the beta-blocker propranolol may increase LDL receptor activity either per se or by its antagonizing effect on the catecholamine action.
Spec (may) Positive_regulation (increase) of LDL receptor associated with beta blocker, catecholamine and antagonist
4) Confidence 0.41 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455133 Disease Relevance 0.17 Pain Relevance 0.59
Both hypothyroidism and hyperthyroidism enhance low density lipoprotein oxidation.
Positive_regulation (enhance) of low density lipoprotein associated with thyroid disease
5) Confidence 0.32 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 9329379 Disease Relevance 1.13 Pain Relevance 0.09
Copper-induced low density lipoprotein oxidation is not a risk discriminator for intermittent claudication.
Positive_regulation (induced) of low density lipoprotein associated with restless leg syndrome
6) Confidence 0.32 Published 1996 Journal VASA Section Title Doc Link 8659213 Disease Relevance 0.88 Pain Relevance 0.49
Various thiazide-type diuretics significantly increased the potentially atherogenic serum low-density lipoprotein cholesterol (LDL-C) and/or very-LDL-C (V-LDL-C) fractions, while the antiatherogenic high-density lipoprotein cholesterol (HDL-C) level was largely unchanged.
Positive_regulation (increased) of atherogenic serum low-density lipoprotein cholesterol associated with disorder of lipid metabolism
7) Confidence 0.26 Published 1984 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6204152 Disease Relevance 0.23 Pain Relevance 0
Various thiazide-type diuretics may significantly increase the potentially atherogenic serum low-density-lipoprotein cholesterol (LDL-C) and/or very-LDL-C-fractions, while the antiatherogenic high-density-lipoprotein cholesterol (HDL-C) is largely unchanged.
Spec (may) Positive_regulation (increase) of serum low-density-lipoprotein cholesterol associated with disorder of lipid metabolism
8) Confidence 0.25 Published 1983 Journal Hypertension Section Abstract Doc Link 6138309 Disease Relevance 0.18 Pain Relevance 0.03
Because hypercholesterolemia, especially increase in low-density lipoprotein (LDL), has been associated with fibrogenesis, we investigated the association of median nerve cross-sectional area and prevalence of idiopathic CTS with serum lipid measurements in middle-aged patients and controls.
Positive_regulation (increase) of low-density lipoprotein in median nerve associated with fibrosis, carpal tunnel syndrome and hyperlipidemia
9) Confidence 0.24 Published 2005 Journal Muscle Nerve Section Abstract Doc Link 15937877 Disease Relevance 0.88 Pain Relevance 0.51
The results show that there were significant (P < 0.05) increases in total serum cholesterol, triglyceride and low-density lipoprotein cholesterol (LDL-C) and a decrease in high-density lipoprotein cholesterol (HDL-C) in streptozotocin-induced diabetic rats.
Positive_regulation (increases) of low-density lipoprotein cholesterol associated with diabetes mellitus and disorder of lipid metabolism
10) Confidence 0.22 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2898543 Disease Relevance 0.85 Pain Relevance 0
The high dietary cholesterol was concerned with the increasing concentrations of serum and hepatic total cholesterol(TC), especially the level of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in serum, which is considered to be a primary risk factor of cardiovascular disease.
Positive_regulation (increasing) of low density lipoprotein associated with cardiovascular disease and disorder of lipid metabolism
11) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.70 Pain Relevance 0
The high dietary cholesterol was concerned with the increasing concentrations of serum and hepatic total cholesterol(TC), especially the level of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in serum, which is considered to be a primary risk factor of cardiovascular disease.
Positive_regulation (increasing) of low density lipoprotein associated with cardiovascular disease and disorder of lipid metabolism
12) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.59 Pain Relevance 0
This requirement is met, in part, by increased hepatic LDL receptor activity, which in turn reduces circulating LDL.
Positive_regulation (increased) of LDL receptor
13) Confidence 0.19 Published 2004 Journal Nutr J Section Body Doc Link PMC522822 Disease Relevance 0.16 Pain Relevance 0.36
RESULTS: We found significant increased cholesterol, low density lipoprotein cholesterol (LDL-C) and oxidized LDL-C in normal weight migraineurs.
Positive_regulation (increased) of low density lipoprotein cholesterol
14) Confidence 0.19 Published 2010 Journal Eur. J. Neurol. Section Body Doc Link 19968707 Disease Relevance 0.09 Pain Relevance 0
The macrophage appears to be at the beginning of a chain of events that starts with elevated low density lipoprotein (LDL).
Positive_regulation (elevated) of low density lipoprotein in macrophage
15) Confidence 0.17 Published 1996 Journal Adv. Neuroimmunol. Section Abstract Doc Link 8876769 Disease Relevance 0.65 Pain Relevance 0.10
It is hypothesized that risk factors such as hypertension, smoking, or elevated levels of low-density lipoprotein (LDL) cholesterol result in injury to the endothelial cell of the artery, and this injury initiates the inflammatory process.
Positive_regulation (elevated) of low-density lipoprotein in artery associated with nicotine addiction, inflammation, injury and hypertension
16) Confidence 0.16 Published 1999 Journal Heart Dis Section Abstract Doc Link 11720630 Disease Relevance 2.49 Pain Relevance 0.34
There was a significant increase (P<0.001) in the level of total cholesterol, triglycerides, low–density, and very low density lipoprotein in the group II animals fed with HFT in comparison with the normal untreated control animals.
Positive_regulation (increase) of low density lipoprotein associated with disorder of lipid metabolism
17) Confidence 0.13 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.54 Pain Relevance 0
Hypercholesterolemia along with high-cholesterol diet and oxidative stress increases serum LDL levels resulting in increased risk for the development of atherosclerosis.[43] Endothelial cells bind LDL and when activated by injury, these cells are attached to monocytes/macrophages and generate free radicals, which oxidize LDL, resulting in LPO and destruction of the receptor needed for the normal receptor-mediated clearance of LDL.[53] Atorvastatin is well known to prevent LPO and increases the LDL receptor expression.[52] In addition, atorvastatin has additional antioxidant property.[54] From the results, it becomes evident that treatment with MEEV also reduced the LPO in a dose-dependent manner, which may be through the mechanism similar to that of statin.
Positive_regulation (increases) of LDL receptor in macrophages associated with stress, atherosclerosis, injury and hyperlipidemia
18) Confidence 0.13 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.43 Pain Relevance 0
Data extracted from hospital charts showed that routine care typically did not collect sufficient information to stratify risk and assign treatment targets for LDL-cholesterol and that there were inconsistencies in identifying patients with normal or elevated levels of LDL-cholesterol in relation to risk.
Positive_regulation (elevated) of LDL-cholesterol
19) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2988621 Disease Relevance 0.08 Pain Relevance 0
These simple statements about target levels can be compared directly with measured levels of LDL-cholesterol to determine whether or not the patient has LDL-cholesterol that is elevated for their risk of coronary events.
Spec (whether) Positive_regulation (elevated) of LDL-cholesterol
20) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988621 Disease Relevance 0.06 Pain Relevance 0

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