INT108641

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk1d) kinase activity (Camk1d) cytoplasm (Camk1d)
Anatomy Link Frequency
hippocampus 1
Camk1d (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 1 97.32 Very High Very High Very High
Hippocampus 16 96.80 Very High Very High Very High
nMDA receptor 8 96.64 Very High Very High Very High
Spinal cord 3 92.80 High High
Inflammation 1 82.40 Quite High
Neuropathic pain 2 81.40 Quite High
allodynia 1 79.72 Quite High
Hyperalgesia 1 79.16 Quite High
Catecholamine 1 78.24 Quite High
cerebral cortex 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Convulsion 5 98.84 Very High Very High Very High
Nociception 1 82.88 Quite High
INFLAMMATION 1 82.40 Quite High
Neuropathic Pain 6 81.40 Quite High
Hyperalgesia 1 79.16 Quite High
Affective Disorder 4 76.96 Quite High
Autism 1 75.80 Quite High
Nervous System Injury 1 58.40 Quite High
Pain 1 57.60 Quite High
Sprains And Strains 47 39.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the B6F2 male-specific MMU2 locus, the expression of Camk1d, which is activated by calcium and calmodulin signaling, is fourfold higher in B6 hippocampus than in R3 hippocampus.
Gene_expression (expression) of Camk1d in hippocampus associated with hippocampus
1) Confidence 0.70 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.15 Pain Relevance 0.27
Each of these changes is prevented in PSD-95 mutant mice although CaM kinase II is present and can be activated.
Gene_expression (present) of CaM kinase
2) Confidence 0.55 Published 2003 Journal Curr. Biol. Section Abstract Doc Link 12593798 Disease Relevance 0.73 Pain Relevance 0.85
Following seizure induction, CaMKII-alpha expression was downregulated and CaMKII-delta expression upregulated while CaMKII-beta and CaMKII-gamma expression was unaffected.
Gene_expression (expression) of CaMKII-delta associated with convulsion
3) Confidence 0.00 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.34 Pain Relevance 0.13

General Comments

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