INT108642

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.87
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk1d) kinase activity (Camk1d) cytoplasm (Camk1d)
Anatomy Link Frequency
neocortex 1
spinal cord 1
Camk1d (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.88 Very High Very High Very High
nMDA receptor 14 98.84 Very High Very High Very High
Inflammation 2 89.36 High High
Neuropathic pain 4 88.36 High High
allodynia 2 86.68 High High
Hyperalgesia 2 86.12 High High
Dorsal horn 2 76.76 Quite High
cerebral cortex 1 75.00 Quite High
Analgesic 2 66.76 Quite High
tetrodotoxin 1 66.64 Quite High
Disease Link Frequency Relevance Heat
Convulsion 5 91.76 High High
Nociception 2 89.84 High High
INFLAMMATION 2 89.36 High High
Neuropathic Pain 12 88.36 High High
Hyperalgesia 2 86.12 High High
Nervous System Injury 2 65.36 Quite High
Pain 3 64.56 Quite High
Cancer 2 50.00 Quite Low
Cancer Pain 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each of these changes is prevented in PSD-95 mutant mice although CaM kinase II is present and can be activated.
Positive_regulation (activated) of CaM kinase
1) Confidence 0.41 Published 2003 Journal Curr. Biol. Section Abstract Doc Link 12593798 Disease Relevance 0.73 Pain Relevance 0.85
In wild-type mice following CCI, CaM kinase II inhibitors attenuate sensitization of behavioral reflexes, elevated constitutive (autophosphorylated) activity of CaM kinase II is detected in spinal cord, and increased amounts of phospho-Thr(286) CaM kinase II coimmunoprecipitate with NMDA receptor NR2A/B subunits.
Positive_regulation (increased) of CaM kinase in spinal cord associated with nmda receptor and spinal cord
2) Confidence 0.38 Published 2003 Journal Curr. Biol. Section Abstract Doc Link 12593798 Disease Relevance 0.79 Pain Relevance 0.91
Validations using Western blotting were successful for the CaM kinase and P2X6.
Positive_regulation (successful) of CaM kinase
3) Confidence 0.14 Published 2005 Journal Int. J. Radiat. Oncol. Biol. Phys. Section Body Doc Link 15817359 Disease Relevance 0 Pain Relevance 0
A transient downregulation in CaMKII-alpha and a transient increase in CaMKII-delta occurred throughout neocortex in the same temporal order.
Positive_regulation (increase) of CaMKII-delta in neocortex
4) Confidence 0.00 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.35 Pain Relevance 0.14

General Comments

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