INT108643

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 61
Total Number 63
Disease Relevance 8.63
Pain Relevance 8.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spine 8
brain 4
synapses 3
dentate gyrus 2
spinal cord 2
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 307 100.00 Very High Very High Very High
Spinal cord 66 100.00 Very High Very High Very High
imagery 383 98.64 Very High Very High Very High
Hyperalgesia 5 97.48 Very High Very High Very High
allodynia 1 96.80 Very High Very High Very High
Somatosensory cortex 56 96.56 Very High Very High Very High
Dorsal horn 59 95.64 Very High Very High Very High
Neuropathic pain 9 95.40 Very High Very High Very High
Glutamate receptor 204 95.24 Very High Very High Very High
medulla 17 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 80 99.92 Very High Very High Very High
Aids-related Complex 43 99.74 Very High Very High Very High
Targeted Disruption 791 99.48 Very High Very High Very High
Repression 6 98.80 Very High Very High Very High
Neuropathic Pain 13 98.36 Very High Very High Very High
Hyperalgesia 6 97.48 Very High Very High Very High
Cognitive Disorder 120 95.60 Very High Very High Very High
Schizophrenia 260 95.00 High High
INFLAMMATION 17 94.24 High High
Nociception 45 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSD-95 expression affects AMPA receptor-mediated excitatory synaptic transmission (Migaud et al, 1998; Beique et al, 2006; Carlisle et al, 2008) and is thought to involve indirect interactions through stargazin, SAP-97, Adam22, Lgi1 and Nsf (Leonard et al, 1998; Osten et al, 1998; Fukata et al, 2006).
Gene_expression (expression) of PSD-95
1) Confidence 0.76 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.09 Pain Relevance 0.08
Together, the physiological, biochemical, tissue and subcellular localization studies indicate that the presence of the TAP tag did not significantly alter the expression or function of PSD-95.


Gene_expression (expression) of PSD-95
2) Confidence 0.76 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.09 Pain Relevance 0.06
As shown in Figure 2B, the expression of PSD-95 in the hippocampal subfields was unaffected by the genetic manipulation and particularly in the stratum radiatum, where the electrophysiological experiments were carried out (described below), was normal.
Gene_expression (expression) of PSD-95
3) Confidence 0.76 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.11
Large PSDs are large sources of diffusing PSD-95, and a net diffusional flux is expected to carry PSD-95 from large to small synapses.
Gene_expression (sources) of PSD-95 in synapses
4) Confidence 0.76 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Spine densities in cells expressing PSD-95-XFP and mCherry (0.30 ± 0.06 spines/?
Gene_expression (expressing) of PSD-95 in spines
5) Confidence 0.76 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
However, analysis of spine morphology and synaptic strength in brain slices harvested from the experimental mice revealed that, under our conditions, the expression of PSD-95-GFP in vivo did not change synaptic strength or spine size (Figure S1).
Gene_expression (expression) of PSD-95-GFP in spine
6) Confidence 0.76 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.20
It has been shown that the overexpression of PSD-95 can enhance synaptic strength [38,39] and spine size [48].
Gene_expression (overexpression) of PSD-95 in spine
7) Confidence 0.76 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.19
Surprisingly, we found that expression of postsynaptic density-95 (PSD95) and synaptophysin (Syp) was significantly downregulated in hypothalamus of Mecp2?
Gene_expression (expression) of postsynaptic density-95 in hypothalamus
8) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.16 Pain Relevance 0
Surprisingly, we found that expression of postsynaptic density-95 (PSD95) and synaptophysin (Syp) was significantly downregulated in hypothalamus of Mecp2?
Gene_expression (expression) of PSD95 in hypothalamus
9) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.16 Pain Relevance 0
We next examined protein expression of TAP-tagged PSD-95 to ensure that introduction of the tag into the gene did not affect the expression and localization of the tagged protein.
Spec (examined) Gene_expression (expression) of TAP-tagged PSD-95
10) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0
Therefore large PSDs contain large PSD-95 clusters and are prominent sources of PSD-95, and the resulting concentration gradients along the dendrite will drive net PSD-95 flux from large PSDs towards small PSDs.
Gene_expression (sources) of PSD-95 in dendrite
11) Confidence 0.66 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 2A, the expression pattern of PSD-95 in PSD-95TAP/TAP brain was the same as in the brains of wt animals, with the highest expression in the CA1 area, dentate gyrus, cortex, cerebellum and lower expression in striatum and brainstem (Figure 2A).
Gene_expression (expression) of PSD-95 in cortex associated with medulla
12) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.05
The MASC MCC had 13 clusters, with cluster 1 containing PSD-95 (Supplementary Figure 6).
Gene_expression (containing) of PSD-95
13) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.18 Pain Relevance 0.05
We measured PSD-95 clusters (Gmax of photoactivated PSD-95-paGFP) and ?
Gene_expression (clusters) of PSD-95-paGFP
14) Confidence 0.66 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.07
To estimate the size of the PSD-95 clusters in PSDs containing PSD-95-paGFP, we measured the green fluorescence approximately 1–2 min after saturating photoactivation and background subtraction.
Gene_expression (containing) of PSD-95-paGFP
15) Confidence 0.66 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.11
Synaptic PSD-95 turned over rapidly (median retention times ?
Gene_expression (turned) of PSD-95
16) Confidence 0.66 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Synaptic PSD-95 turned over rapidly (median retention times ?
Gene_expression (Synaptic) of PSD-95
17) Confidence 0.66 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Using mutant mice expressing a truncated form of the PSD-95 molecule, we show their failure to develop the NMDA receptor-dependent hyperalgesia and allodynia seen in the CCI model of neuropathic pain, but normal inflammatory nociceptive behavior following the injection of formalin.
Gene_expression (expressing) of PSD-95 molecule associated with nociception, hyperalgesia, inflammation, allodynia, nmda receptor and neuropathic pain
18) Confidence 0.62 Published 2003 Journal Curr. Biol. Section Abstract Doc Link 12593798 Disease Relevance 0.91 Pain Relevance 0.98
The steady state level of PSD95 and Syp mRNAs in Mecp2?
Gene_expression (mRNAs) of PSD95
19) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0
These changes in spine density were accompanied by altered expression of proteins known to interact with PSD-95, including NR2B and SAP102, suggesting that PSD-95 plays a role in regulating the expression and activation of proteins found within the NMDA receptor complex.
Gene_expression (expression) of PSD-95 in spine associated with nmda receptor
20) Confidence 0.60 Published 2006 Journal Brain Res. Section Abstract Doc Link 16677619 Disease Relevance 0.08 Pain Relevance 0.28

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