INT108689

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.39
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 3 99.96 Very High Very High Very High
Gabapentin 3 99.48 Very High Very High Very High
Potency 2 99.04 Very High Very High Very High
Action potential 1 98.44 Very High Very High Very High
Analgesic 11 96.92 Very High Very High Very High
Root ganglion neuron 1 95.96 Very High Very High Very High
Abeta 1 93.28 High High
Adelta 1 92.88 High High
Pain 17 92.36 High High
anticonvulsant 1 91.20 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 1 97.44 Very High Very High Very High
Ganglion Cysts 2 95.64 Very High Very High Very High
Nervous System Injury 7 93.52 High High
Pain 11 92.36 High High
Syndrome 1 75.96 Quite High
Neuropathic Pain 5 75.56 Quite High
Photophobia 1 70.24 Quite High
Autoimmune Disease 1 66.40 Quite High
Viral Infection 1 63.32 Quite High
Injury 1 62.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we tested the effect of intrathecal ZD7288, an HCN channel inhibitor, and its interaction with intrathecal gabapentin in the rat formalin test.
Negative_regulation (inhibitor) of HCN channel associated with gabapentin and intrathecal
1) Confidence 0.38 Published 2009 Journal Eur J Anaesthesiol Section Abstract Doc Link 19322095 Disease Relevance 0 Pain Relevance 0.54
Pharmacological blockade of HCN activity using the specific inhibitor ZD7288 reverses abnormal hypersensitivity to light touch and decreases the firing frequency of ectopic discharges originating in Abeta and Adelta fibers by 90 and 40%, respectively, without conduction blockade.
Negative_regulation (blockade) of HCN associated with adelta, hypersensitivity and abeta
2) Confidence 0.37 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12598605 Disease Relevance 1.13 Pain Relevance 0.84
Although a number of HCN blockers are available, such as ZD-7288, ivabradine, and others, these drugs inhibit all HCN isoforms with the same potency.
Negative_regulation (inhibit) of HCN associated with potency
3) Confidence 0.24 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19519450 Disease Relevance 0.62 Pain Relevance 0.70
Although a number of HCN blockers are available, such as ZD-7288, ivabradine, and others, these drugs inhibit all HCN isoforms with the same potency.
Negative_regulation (blockers) of HCN associated with potency
4) Confidence 0.24 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19519450 Disease Relevance 0.64 Pain Relevance 0.71

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox