INT108691

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.91
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 101 99.36 Very High Very High Very High
antagonist 29 98.96 Very High Very High Very High
c fibre 19 97.88 Very High Very High Very High
antidepressant 2 95.68 Very High Very High Very High
qutenza 91 93.84 High High
trigeminal ganglion 59 89.16 High High
TRP channel 14 86.92 High High
IPN 5 85.36 High High
agonist 32 83.92 Quite High
Inflammation 68 83.36 Quite High
Disease Link Frequency Relevance Heat
Injury 23 99.36 Very High Very High Very High
Ganglion Cysts 74 89.16 High High
Inflammatory Pain 5 85.36 High High
INFLAMMATION 70 83.36 Quite High
Hyperalgesia 15 74.64 Quite High
Nociception 28 70.88 Quite High
Headache 7 67.76 Quite High
Pain 30 67.08 Quite High
Headache Disorders 1 61.84 Quite High
Neuropathic Pain 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the mechanism underlying this effect is not known, it could involve an alteration in post-translational modifications and/or protein interactions of TRPV1 in response to NGF or GDNF.
Regulation (alteration) of TRPV1 Binding (interactions) of associated with nerve growth factor
1) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 1.21 Pain Relevance 1.31
Although structural/functional studies have identified some of the key amino acids influencing the gating of the TRPV1 ion channel, the possible contributions of terminal regions to vanilloid receptor function remain elusive.
Regulation (influencing) of TRPV1 Binding (gating) of
2) Confidence 0.45 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12598622 Disease Relevance 0 Pain Relevance 0.09
Given that there are functional interactions between TRPA1 and TRPV1 in vitro and in vivo (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2007), it is interesting to speculate that a TRPA1/TRPV1 interaction may be responsible for the lower heat thresholds seen in the polymodal C-fibres that express TRPA1 in comparison to those that do not.
Spec (may) Regulation (responsible) of TRPV1 Binding (interaction) of associated with c fibre
3) Confidence 0.36 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.61 Pain Relevance 0.58
We hypothesized that calmodulin antagonists and some registered drugs may exert their blocking effect with another mechanisms on TRPV1 and not necessarily on their conventional target.
Spec (may) Regulation (effect) of TRPV1 Binding (target) of associated with antagonist
4) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.09 Pain Relevance 0.52

General Comments

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