INT1087

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 8.35
Pain Relevance 10.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) plasma membrane (Msr1)
Anatomy Link Frequency
semitendinosus 2
mononuclear phagocytes 2
dorsal root 2
neuronal 2
horn 2
Msr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 16 99.98 Very High Very High Very High
Clonidine 9 99.86 Very High Very High Very High
rapifen 11 99.84 Very High Very High Very High
noradrenaline 16 99.54 Very High Very High Very High
Serotonin 12 99.52 Very High Very High Very High
monoamine 15 99.44 Very High Very High Very High
agonist 7 99.22 Very High Very High Very High
fluoxetine 31 99.20 Very High Very High Very High
nMDA receptor 9 98.96 Very High Very High Very High
Dorsal horn 2 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 317 100.00 Very High Very High Very High
Targeted Disruption 112 100.00 Very High Very High Very High
Frailty 6 99.24 Very High Very High Very High
Atherosclerotic Plaque 5 98.60 Very High Very High Very High
Myeloid Leukemia 55 98.10 Very High Very High Very High
Infection 37 93.84 High High
Depression 3 93.56 High High
Immunization 5 91.08 High High
Non-diabetic Peripheral Neuropathy 2 89.92 High High
Injury 53 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of MSR-A and CD36 has been shown to reduce atherosclerotic plaque size [35] and foam-cell formation [36].
Negative_regulation (Inhibition) of MSR-A in plaque associated with atherosclerotic plaque
1) Confidence 0.57 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.59 Pain Relevance 0.03
This inhibition of the flexor (posterior biceps-semitendinosus) MSR was not altered by fluoxetine.
Negative_regulation (inhibition) of MSR in semitendinosus associated with fluoxetine
2) Confidence 0.50 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086701 Disease Relevance 0 Pain Relevance 0.45
These results support our previous proposal (ref. 18) that a supraspinal system involving 5-HT and noradrenaline antagonizes recurrent inhibition of the quadriceps MSR.
Negative_regulation (inhibition) of MSR in quadriceps associated with noradrenaline
3) Confidence 0.50 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086701 Disease Relevance 0 Pain Relevance 0.45
Diazepam (10 mg/kg) did not decrease MSR, but slightly reduced PSR.
Neg (not) Negative_regulation (decrease) of MSR
4) Confidence 0.49 Published 1984 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6151605 Disease Relevance 0.28 Pain Relevance 0
These results support our earlier proposal that a 5-HT system antagonizes bulbospinal inhibition of the MSR.
Negative_regulation (inhibition) of MSR
5) Confidence 0.44 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086122 Disease Relevance 0 Pain Relevance 0.47
This shows that the lack of SR-A receptors does not affect the establishment of a protective immune response against RAS.
Negative_regulation (lack) of SR-A
6) Confidence 0.42 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 0.80 Pain Relevance 0.03
It is concluded that inhibition of the MSR and PSR does not involve mediation by glycine, GABAA nor NMDA receptors, nor release of enkephalins nor noradrenaline.
Negative_regulation (inhibition) of MSR associated with nmda receptor, noradrenaline and enkephalin
7) Confidence 0.40 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.37
Inhibition of the MSR and PSR was not reduced by 1 microM naloxone, 1 microM strychnine, 1 microM bicuculline nor 10-30 microM APV.
Negative_regulation (Inhibition) of MSR associated with narcan
8) Confidence 0.40 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.23
Inhibition of the MSR was only elicited ipsilaterally and that of PSR was reduced by about 50% on stimulation of the contralateral thoracic cord; inhibition of CON FAST could be evoked from either side of the cord.
Negative_regulation (Inhibition) of MSR in thoracic
9) Confidence 0.40 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.08
Recurrent inhibition of the extensor (quadriceps) monosynaptic reflex (MSR) was antagonized by a 5-hydroxytryptamine (5-HT) precursor, 5-hydroxytryptophan (5-HTP, 75 mg/kg), and a specific 5-HT neuronal uptake blocker, fluoxetine-HC1 (Lilly 110140, 0.25-6 mg/kg), in unanaesthetized decerebrate cats.
Negative_regulation (inhibition) of MSR in neuronal associated with fluoxetine
10) Confidence 0.37 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086701 Disease Relevance 0 Pain Relevance 0.36
The MSR was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of MSR
11) Confidence 0.37 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 7640126 Disease Relevance 0.15 Pain Relevance 0.92
Cyproheptadine (2.5-5 mg/kg) or phenoxybenzamine-HC1 (2.5-5 mg/kg), administered alone, enhanced recurrent inhibition of the extensor but not of the flexor MSR.
Negative_regulation (inhibition) of MSR
12) Confidence 0.37 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086701 Disease Relevance 0 Pain Relevance 0.50
Neither spiroxatrine (0.1 microM) nor methysergide (5-10 nM) altered inhibition of the MSR.
Negative_regulation (inhibition) of MSR
13) Confidence 0.35 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.36
This was probably due to 5-HT2 receptor blockade, since 0.1 microM yohimbine had little blocking action and 1 microM idazoxan none, nor did 0.1 microM clonidine mimic inhibition of the MSR.
Negative_regulation (inhibition) of MSR associated with clonidine
14) Confidence 0.35 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.23
Imipramine HCl (0.125 - 4 mg/kg) was more potent in antagonizing bulbospinal inhibition of the dorsal root-ventral root MSR when administered intra-arterially to the spinal cord than when injected intra-arterially to the brain stem or intravenously, indicating that the spinal cord is the site of imipramine's action.
Negative_regulation (inhibition) of MSR in spinal cord associated with spinal cord
15) Confidence 0.32 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086122 Disease Relevance 0 Pain Relevance 0.51
Fluoxetine HCl (Lilly 110140, 0.25 - 6 mg/kg), a specific serotonin neuronal uptake blocker, also blocked this inhibition as well as bulbospinal inhibition of the flexor posterior biceps-semi-tendinosus MSR.
Negative_regulation (inhibition) of MSR in posterior associated with serotonin and fluoxetine
16) Confidence 0.32 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086122 Disease Relevance 0 Pain Relevance 0.48
The microinjection of gabapentin (1.5 and 5 nmol) into the ventral horn reduced both MSR and PSR, whereas the injection into the dorsal horn only inhibited the PSR, indicating that systemic gabapentin inhibits the MSR at the ventral horn and it inhibits the PSR at both the ventral and dorsal horns.
Negative_regulation (reduced) of MSR in horn associated with dorsal horn and gabapentin
17) Confidence 0.28 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15599106 Disease Relevance 0.22 Pain Relevance 0.89
Cyproheptadine (2.5--5 mg/kg); phenoxybenzamine hydrochloride (2.5-5 mg/kg) and a cold block enhanced the inhibition of this extensor MSR but a cold block failed to alter the inhibition in animals pretreated with p-CPA or a-MPT.
Negative_regulation (inhibition) of MSR in CPA
18) Confidence 0.26 Published 1977 Journal Brain Res. Section Abstract Doc Link 139193 Disease Relevance 0 Pain Relevance 0.38
Both 8-OH-DPAT (1-3 microM) and dipropyl-5-CT (1 microM) preferentially depressed the MSR.
Negative_regulation (depressed) of MSR
19) Confidence 0.26 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.35
Prazosin (0.1 microM) did not affect inhibition of the MSR but yohimbine (1 microM) blocked it as effectively as ketanserin.
Negative_regulation (inhibition) of MSR
20) Confidence 0.26 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.20

General Comments

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