INT10870

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 67
Total Number 70
Disease Relevance 43.27
Pain Relevance 12.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
nasal 2
lung 2
B-cells 2
anterior 1
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 294 100.00 Very High Very High Very High
Inflammation 265 100.00 Very High Very High Very High
Arthritis 59 100.00 Very High Very High Very High
Neuropeptide 18 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
rheumatoid arthritis 208 99.84 Very High Very High Very High
Pain 45 99.54 Very High Very High Very High
anesthesia 28 99.54 Very High Very High Very High
ketamine 14 99.32 Very High Very High Very High
spinal inflammation 31 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 430 100.00 Very High Very High Very High
INFLAMMATION 269 100.00 Very High Very High Very High
Arthritis 72 100.00 Very High Very High Very High
Corneal Disease 5 100.00 Very High Very High Very High
Multiple Myeloma 10 99.98 Very High Very High Very High
Rheumatoid Arthritis 209 99.84 Very High Very High Very High
Immunization 331 99.76 Very High Very High Very High
Viral Meningitis 116 99.72 Very High Very High Very High
Influenza Virus Infection 336 99.68 Very High Very High Very High
Bacterial Infection 11 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytoplasmic requirements for the radio-induced modulation of IgG receptors on B-cells.
Regulation (modulation) of IgG in B-cells
1) Confidence 0.59 Published 1982 Journal Immunol. Lett. Section Title Doc Link 6299936 Disease Relevance 0 Pain Relevance 0.07
The effect of X-ray irradiation on IgG membrane receptors of B murine lymphocytes was studied.
Regulation (effect) of IgG in lymphocytes
2) Confidence 0.43 Published 1982 Journal Immunol. Lett. Section Abstract Doc Link 6299936 Disease Relevance 0 Pain Relevance 0
The effects of two endogenous mammalian FMRFamide (Phe-Met-Arg-Phe-NH2)-related peptides, an octapeptide F8Fa (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) and an octadecapeptide A18Fa (Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Pro-Gln-Arg-Phe-NH2 ), and IgG from serum against them on the responses to aggression and defeat-induced analgesia were examined in subordinate mice in "resident-intruder" pairings.
Regulation (effects) of IgG associated with aggression and analgesia
3) Confidence 0.43 Published 1991 Journal Peptides Section Abstract Doc Link 2067975 Disease Relevance 0.30 Pain Relevance 0.41
Effects of mammalian FMRF-NH2-related peptides and IgG from antiserum against them on aggression and defeat-induced analgesia in mice.
Regulation (Effects) of IgG associated with aggression, neuropeptide and analgesia
4) Confidence 0.43 Published 1991 Journal Peptides Section Title Doc Link 2067975 Disease Relevance 0.38 Pain Relevance 0.86
However, as a result no significant differences in IgG levels were observed between the patients with ophthalmic ZSH and the control group (Table 2).
Neg (no) Regulation (differences) of IgG associated with zoster sine herpete
5) Confidence 0.41 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915869 Disease Relevance 0.88 Pain Relevance 0.03
In the present study determinations were made of the effects of NPFF and IgG from antiserum against NPFF on the spatial performance of male mice in a water maze task, whereby over one day in six blocks of four trials the animals had to acquire the location of a submerged hidden platform using distal visual cues.
Regulation (effects) of IgG
6) Confidence 0.37 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8233035 Disease Relevance 0 Pain Relevance 0.44
Sex differences in the effects of neuropeptide FF and IgG from neuropeptide FF on morphine- and stress-induced analgesia.
Regulation (effects) of IgG associated with stress, pain, neuropeptide, analgesia and morphine
7) Confidence 0.35 Published 1992 Journal Peptides Section Title Doc Link 1523172 Disease Relevance 0.42 Pain Relevance 1.69
In the present study, determinations were made of the effects of NPFF and IgG from antiserum against NPFF on morphine- and restraint stress-induced opioid analgesia in male and female deer mice.
Regulation (effects) of IgG associated with stress, opioid, analgesia and morphine
8) Confidence 0.35 Published 1992 Journal Peptides Section Abstract Doc Link 1523172 Disease Relevance 0.37 Pain Relevance 1.53
Thus, despite the accelerated decay of IgG in FcRn-deficient mice [13,15,16], the initial antibody titers following aerosol challenge were unaffected.
Neg (unaffected) Regulation (unaffected) of IgG
9) Confidence 0.29 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.96 Pain Relevance 0
Follow-up studies revealed changes in the oligoclonal IgG during the course of GBS and LMR.
Regulation (changes) of IgG associated with syndrome
10) Confidence 0.27 Published 1981 Journal J. Neurol. Section Abstract Doc Link 6181212 Disease Relevance 0.69 Pain Relevance 0
The results show that X-ray irradiation results in a modulation of IgG receptor molecules on B-cells.
Regulation (modulation) of IgG in B-cells
11) Confidence 0.26 Published 1982 Journal Immunol. Lett. Section Abstract Doc Link 6299936 Disease Relevance 0 Pain Relevance 0.08
Interestingly, four patients in the post-RTX group did not respond in any IgG subclass against influenza immunization.
Neg (not) Regulation (respond) of IgG associated with influenza virus infection and immunization
12) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.58 Pain Relevance 0
As glycosylation changes in IgG in RA are well established, the current study was undertaken to measure the expression of the carbohydrate antigen sialyl Lewis x (sLe(x)), on IgG in RA. sLe(x) is a major ligand for E-selectin.
Regulation (changes) of IgG associated with rheumatoid arthritis
13) Confidence 0.21 Published 1998 Journal Glycoconj. J. Section Abstract Doc Link 10372970 Disease Relevance 1.21 Pain Relevance 0.44
We next investigated whether SP-A binding could functionally affect IgG-mediated phagocytosis of C. neoformans by alveolar macrophages in vitro.
Regulation (affect) of IgG in alveolar macrophages
14) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2147053 Disease Relevance 0 Pain Relevance 0
In spite of this, however, the treatment did not have any effect on RF-IgM or anti-CCP IgG content in synovia with lymphoid aggregates, even though these tissues produced massively increased levels of autoantibodies compared with synovia with diffuse infiltration.
Regulation (effect) of IgG
15) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0.03
Similarly, the influenza-specific serum IgG response was also greater in the VAD mice than in the control mice during both the mild infection (VAD, 194 +/- 91 mg/L vs. control, 79 +/- 95 mg/L at 5 wk, P = 0.0002) and the severe infection [VAD median, 202 mg/L (25th, 75th percentiles, 153, 409 mg/L) vs. control, 123 mg/L (42, 165 mg/L), P = 0.0023].
Regulation (response) of IgG associated with influenza virus infection and infection
16) Confidence 0.16 Published 1996 Journal J. Nutr. Section Abstract Doc Link 8558330 Disease Relevance 1.17 Pain Relevance 0.15
IgA, IgG and IgM all dropped as well, but the change in IgG was the greatest, and the decreases were more marked in valve replacement patients than in aorto-coronary bypass patients.
Regulation (change) of IgG
17) Confidence 0.15 Published 1989 Journal Masui Section Abstract Doc Link 2614885 Disease Relevance 0.08 Pain Relevance 0.28
The radiotherapeutic SWCNT constructs, labeled with 225Ac, were also functionalized with multiple copies of E4G10 antibody and used to treat LS174T tumors vs low SA control, nontargeting high SA isotype IgG control, and growth control.
Regulation (control) of IgG in LS174T associated with cancer
18) Confidence 0.13 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.81 Pain Relevance 0.03
On day 21, the impairment of humoral responses was more pronounced with respect to influenza as compared with the pneumococcal vaccine and affected both IgG and light-chain production.
Regulation (affected) of IgG associated with influenza virus infection
19) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911904 Disease Relevance 0.83 Pain Relevance 0.21
Given that antibodies are extraordinarily powerful at neutralizing virus, preventing further infection, clearing antigen and even dampening inflammation via FcR ligation, the accelerated IgG and IgA responses in the lung most likely contribute, at least partially, to the enhanced viral clearance in PCN-treated mice.
Spec (likely) Regulation (responses) of IgG in lung associated with inflammation and infection
20) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.77 Pain Relevance 0.12

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