INT108723

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.26
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo)
Anatomy Link Frequency
platelet 5
monocyte 1
Thpo (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 25 99.96 Very High Very High Very High
Paracetamol 4 96.56 Very High Very High Very High
Angina 5 54.16 Quite High
headache 6 18.44 Low Low
anesthesia 3 7.20 Low Low
cva 9 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
peptic ulcer disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 183 99.92 Very High Very High Very High
Nicotine Addiction 10 98.08 Very High Very High Very High
Acute Liver Failure 8 97.32 Very High Very High Very High
Myelodysplastic Syndromes 12 96.60 Very High Very High Very High
Leukemia 3 96.56 Very High Very High Very High
Hematologic Neoplasms 3 93.60 High High
Cirrhosis 1 90.48 High High
Cv General 3 Under Development 8 83.00 Quite High
Infection 7 78.80 Quite High
Emergencies 3 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TPO levels from hospital day 2 were elevated in 43% of patients, normal in 47%, and decreased in 10% of patients.
Negative_regulation (decreased) of TPO
1) Confidence 0.59 Published 2003 Journal Hepatology Section Abstract Doc Link 12601353 Disease Relevance 0.88 Pain Relevance 0.26
In vitro, the plasma from cigarette smokers, but not from nonsmoking controls, primed platelet-monocyte binding, which was reduced when an inhibitor of TPO was used.
Negative_regulation (inhibitor) of TPO in monocyte associated with nicotine addiction
2) Confidence 0.55 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.88 Pain Relevance 0.08
In vitro, the plasma from UA patients, but not from SA patients or healthy controls, primed platelet aggregation and monocyte-platelet binding, which were both reduced when an inhibitor of TPO was used.
Negative_regulation (inhibitor) of TPO in platelet
3) Confidence 0.52 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 17161245 Disease Relevance 0.05 Pain Relevance 0
Inadequate low thrombopoietin (TPO) levels are associated with insufficient proliferation and differentiation of megakaryocytes, decreased proplatelet formation, and subsequent platelet release.
Negative_regulation (decreased) of thrombopoietin in platelet
4) Confidence 0.40 Published 2010 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2880346 Disease Relevance 0.41 Pain Relevance 0
Inadequate low thrombopoietin (TPO) levels are associated with insufficient proliferation and differentiation of megakaryocytes, decreased proplatelet formation, and subsequent platelet release.
Negative_regulation (decreased) of TPO in platelet
5) Confidence 0.40 Published 2010 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2880346 Disease Relevance 0.41 Pain Relevance 0
After cessation of TPO agonist this effect was reversible in all but 1 patient, who progressed to secondary acute myeloid leukemia.42

Increasing platelet survival: splenectomy, immunoglobulins and vinca loaded platelets

Negative_regulation (cessation) of TPO in platelets associated with leukemia and agonist
6) Confidence 0.39 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 0.54 Pain Relevance 0.17
We measured TPO and C-reactive protein (CRP), as well as monocyte-platelet binding and the platelet expression of P-selectin and of the TPO receptor, c-Mpl.
Negative_regulation (measured) of TPO in platelet
7) Confidence 0.33 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 17161245 Disease Relevance 0.08 Pain Relevance 0

General Comments

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