INT108728

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.65
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ATP1A2) plasma membrane (ATP1A2) locomotion (ATP1A2)
transmembrane transport (ATP1A2) cytoplasm (ATP1A2)
ATP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 32 99.64 Very High Very High Very High
depression 1 97.72 Very High Very High Very High
Calcium channel 1 93.96 High High
headache 1 87.16 High High
potassium channel 1 84.88 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 27 99.64 Very High Very High Very High
Hemiplegia 2 98.92 Very High Very High Very High
Headache 8 98.72 Very High Very High Very High
Depression 1 97.72 Very High Very High Very High
Epilepsy 2 95.64 Very High Very High Very High
Paresis 2 95.00 High High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further discuss the roles of CACNA1A, ATP1A2, and SCN1A in the pathophysiology of cortical spreading depression, which is the likely correlate of migraine aura.
Regulation (roles) of ATP1A2 associated with epilepsy, depression and migraine
1) Confidence 0.45 Published 2006 Journal Nervenarzt Section Abstract Doc Link 16915377 Disease Relevance 1.03 Pain Relevance 0.72
Here we describe a unique FHM family in which two novel allelic missense mutations in the Na,K-ATPase gene ATP1A2 segregate in the proband with hemiplegic migraine.
Regulation (segregate) of ATP1A2 associated with migraine
2) Confidence 0.44 Published 2007 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 17473835 Disease Relevance 0.74 Pain Relevance 0.62
CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM.
Regulation (reported) of ATP1A2 associated with migraine
3) Confidence 0.29 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19007941 Disease Relevance 0.64 Pain Relevance 0.54
CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM.
Regulation (reported) of FHM2 associated with migraine
4) Confidence 0.29 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19007941 Disease Relevance 0.64 Pain Relevance 0.54
Here, we report the FHM2 locus refining by linkage analysis on two large Italian families affected by pure FHM.
Regulation (affected) of FHM2 associated with migraine
5) Confidence 0.10 Published 2003 Journal Ann. Neurol. Section Abstract Doc Link 12601705 Disease Relevance 0.60 Pain Relevance 0.61

General Comments

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