INT108729

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (CACNA1A, Cacna1a) plasma membrane (CACNA1A, Cacna1a) nucleus (CACNA1A, Cacna1a)
transmembrane transport (CACNA1A, Cacna1a) cytoplasm (CACNA1A, Cacna1a) transport (Cacna1a)
CACNA1A (Homo sapiens)
Cacna1a (Mus musculus)
CACNA1A - T666M (1)
Pain Link Frequency Relevance Heat
Migraine 9 100.00 Very High Very High Very High
headache 1 98.92 Very High Very High Very High
Calcium channel 1 91.60 High High
potassium channel 1 56.96 Quite High
Disease Link Frequency Relevance Heat
Migraine With Aura 9 100.00 Very High Very High Very High
Headache 1 98.92 Very High Very High Very High
Paresis 1 98.08 Very High Very High Very High
Recurrence 1 79.20 Quite High
Channelopathies 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One exception is the recurrent T666M mutation in the FHM1 CACNA1A gene that was identified in almost one-third of FHM families and showed variable associated clinical features and severity, both within and among FHM families.
FHM (T666M) Binding (one-third) of FHM
1) Confidence 0.13 Published 2007 Journal J. Hum. Genet. Section Abstract Doc Link 17952365 Disease Relevance 0.33 Pain Relevance 0.25
The existence of slots generates predictions for how neurotransmission might be affected by changes in Ca2+ channel properties, which we tested by studying alpha1A mutations that are associated with familial hemiplegic migraine type 1 (FHM1).
FHM1 Binding (associated) of alpha1A associated with migraine with aura and migraine
2) Confidence 0.01 Published 2004 Journal Neuron Section Abstract Doc Link 15294146 Disease Relevance 0.25 Pain Relevance 0.10
Two chromosomal loci are associated to FHM: FHM1 on chromosome 19 and FHM2 on chromosome 1q21-23.
FHM Binding (associated) of FHM1 associated with migraine
3) Confidence 0.01 Published 2003 Journal Ann. Neurol. Section Abstract Doc Link 12601705 Disease Relevance 0.63 Pain Relevance 0.61

General Comments

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