INT108735

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 2
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 22 98.04 Very High Very High Very High
antagonist 1 87.44 High High
opioid receptor 2 83.52 Quite High
Inflammation 3 81.28 Quite High
Spinal cord 54 71.76 Quite High
Opioid 1 66.88 Quite High
Sciatic nerve 77 57.52 Quite High
Pain 7 50.00 Quite Low
allodynia 31 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 55 98.48 Very High Very High Very High
Targeted Disruption 98 93.44 High High
Apoptosis 1 82.60 Quite High
INFLAMMATION 3 81.28 Quite High
Nervous System Injury 32 5.00 Very Low Very Low Very Low
Hyperalgesia 17 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a first set of experiments, we assessed the influence of NOS1 or NOS2 deletion in the development and expression of peripheral neuropathic pain.
Regulation (influence) of Localization (deletion) of NOS2 associated with neuropathic pain
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.36 Pain Relevance 0.20
On the other hand in vivo endomorphins had suppressive effect on NO release as well as on NOS 2 and IL-1 protein concentration.
Regulation (effect) of Neg (NO) Localization (release) of NOS 2
2) Confidence 0.38 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20004470 Disease Relevance 0.16 Pain Relevance 0.26
Inhibitory effects of these drugs on lipopolysaccharide (LPS)-induction of inducible nitric oxide synthase (iNOS) and LPS-stimulated translocation of NficB were determined by use of RAW 264.7 murine macrophages.
Regulation (effects) of Localization (translocation) of iNOS in macrophages
3) Confidence 0.32 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0

General Comments

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