INT10874

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 89
Total Number 92
Disease Relevance 36.84
Pain Relevance 11.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
neutrophil 3
smooth muscle 2
brain structures 2
eyes 2
paw 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 47 99.90 Very High Very High Very High
Inflammation 1137 99.78 Very High Very High Very High
long-term potentiation 458 99.76 Very High Very High Very High
Analgesic 21 99.04 Very High Very High Very High
Neuropeptide 6 98.72 Very High Very High Very High
Pain 83 98.44 Very High Very High Very High
c fibre 6 97.96 Very High Very High Very High
Hippocampus 97 97.88 Very High Very High Very High
imagery 49 97.60 Very High Very High Very High
antagonist 40 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 552 100.00 Very High Very High Very High
Apoptosis 133 99.92 Very High Very High Very High
Pulmonary Disease 968 99.84 Very High Very High Very High
INFLAMMATION 1240 99.78 Very High Very High Very High
Age-related Macular Degeneration 473 99.78 Very High Very High Very High
Pulmonary Hypertension 297 99.64 Very High Very High Very High
Cognitive Disorder 764 99.56 Very High Very High Very High
Vomiting 163 99.44 Very High Very High Very High
Asthma 424 99.38 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 23 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, so-called intense pulsed light (IPL) has been evaluated for PDT (Kim et al 2005; Gold et al 2006), although there is a report on dramatically decreased PDT reaction using IPL compared to broad-band light source (Strasswimmer and Grande 2006).
Negative_regulation (decreased) of PDT in band
1) Confidence 0.50 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.08 Pain Relevance 0
Conversely, shRNA-mediated knockdown of twist1 in Th1 cells significantly enhanced their potential to induce chronic inflammation in a murine model of antigen-induced arthritis.
Negative_regulation (knockdown) of twist1 in Th1 cells associated with inflammation and arthritis
2) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.69 Pain Relevance 0.40
In addition, the Pa-PDT mediated inhibition on P-glycoprotein was reversed by JNK inhibitor, as the intensity of Rh-123 was found to be 42.7% in 0.6 ?
Negative_regulation (inhibition) of Pa-PDT
3) Confidence 0.42 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.37 Pain Relevance 0
Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively.
Negative_regulation (inhibitor) of PDE in paw associated with pressure and volume under development, inflammation and analgesic
4) Confidence 0.40 Published 2000 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11233080 Disease Relevance 0.61 Pain Relevance 0.58
Further, nimesulide (0.5 mg/kg) potentiated analgesic effect of rolipram but it failed to modulate the anti-inflammatory effect of PDE inhibitors.
Negative_regulation (inhibitors) of PDE associated with inflammation and analgesic
5) Confidence 0.40 Published 2000 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11233080 Disease Relevance 0.61 Pain Relevance 0.61
Historically, PDT has been limited by a lack of suitable photosensitive dyes.
Negative_regulation (limited) of PDT
6) Confidence 0.37 Published 2004 Journal Expert Opin Drug Saf Section Abstract Doc Link 15268651 Disease Relevance 0.60 Pain Relevance 0
The singlet oxygen is generally believed to be one of the key factors for the desired therapeutic effect of PDT (Weishaupt et al 1976; Moan and Sommer 1985).
Negative_regulation (effect) of PDT
7) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.43 Pain Relevance 0
Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively.
Negative_regulation (inhibitor) of PDE in paw associated with pressure and volume under development, inflammation and analgesic
8) Confidence 0.35 Published 2000 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11233080 Disease Relevance 0.61 Pain Relevance 0.59
OBJECTIVE: We sought to summarize the effectiveness of interventions to reduce ALA-PDT-related pain, and to explore factors contributing to pain induction.
Negative_regulation (reduce) of ALA-PDT
9) Confidence 0.31 Published 2009 Journal J. Am. Acad. Dermatol. Section Body Doc Link 19925929 Disease Relevance 0.10 Pain Relevance 0
Interestingly, we revealed that the expression of P-glycoprotein was down regulated dose-dependently in R-HepG2 cells at 2 h after Pa-PDT treatment (Figure 4A), with induction of phosphorylated JNK and down-regulation of a PDT-resistant protein p-Erk when compared to the control that was treated with 0.4 ?
Negative_regulation (regulation) of PDT
10) Confidence 0.31 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.13 Pain Relevance 0
Most importantly we showed that the observed PDT anti-tumor effects are completely abolished when there is no functional adaptive immune response.
Negative_regulation (abolished) of PDT associated with cancer
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.17 Pain Relevance 0.03
Lack of adaptive immune system abrogates PDT anti-tumor effects
Negative_regulation (abrogates) of PDT in immune system associated with cancer
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 0.91 Pain Relevance 0
Study groups receiving the combination of PDE inhibitors exhibited no additive or synergistic effects compared to each PDE inhibitor used on its own in altering TNF-?
Negative_regulation (inhibitor) of PDE
13) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.15 Pain Relevance 0.14
Inhibition of neutrophil recruitment was also associated with PDE mRNA inhibition in vivo.
Negative_regulation (inhibition) of PDE mRNA in neutrophil
14) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.32 Pain Relevance 0.13
Because PDE4B, 4D and 7A are expressed to different levels in different cell types, these data do not allow us to determine in which cellular subset in the BAL fluid the inhibition of PDE mRNA was the most efficient.
Negative_regulation (inhibition) of PDE mRNA
15) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.37 Pain Relevance 0.13
To determine whether inhibition of neutrophil recruitment was correlated with PDE mRNA inhibition in vivo, the expression of target mRNAs was measured in BAL cells collected the day after the last smoke exposure.
Spec (whether) Negative_regulation (inhibition) of PDE mRNA in neutrophil
16) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.07 Pain Relevance 0.07
Nevertheless, these results are consistent with the idea that downregulating different PDE subtypes in different cell populations which together orchestrate the inflammatory response is required to achieve a protective effect against neutrophils in vivo.
Negative_regulation (downregulating) of PDE in neutrophils associated with inflammatory response
17) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.31 Pain Relevance 0.14
These results demonstrate that concentrations of rolipram, similar to those which inhibit PDE, reduce the release of sensory neuropeptides from C-fibre endings, and suggest that the cyclic adenosine monophosphate (AMP) PDE type IV is specifically involved in this effect, as in other anti-inflammatory effects.
Negative_regulation (inhibit) of PDE associated with c fibre, adenocard, inflammation and neuropeptide
18) Confidence 0.23 Published 1994 Journal Eur. Respir. J. Section Abstract Doc Link 8162984 Disease Relevance 0.09 Pain Relevance 0.36
The drugs used were siguazodan, rolipram and zaprinast, which specifically inhibit PDE types, III, IV and V, respectively.
Negative_regulation (inhibit) of PDE
19) Confidence 0.23 Published 1994 Journal Eur. Respir. J. Section Abstract Doc Link 8162984 Disease Relevance 0 Pain Relevance 0.11
As theophylline might exert this effect through an inhibition of phosphodiesterases (PDE), and since many types of PDE have now been described, the aim of this study was to investigate the effects of three specific inhibitors of PDE on the electrical field stimulation (EFS) of the guinea-pig isolated main bronchus in vitro.
Negative_regulation (inhibition) of PDE in main bronchus
20) Confidence 0.23 Published 1994 Journal Eur. Respir. J. Section Abstract Doc Link 8162984 Disease Relevance 0 Pain Relevance 0

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