INT108761

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 13.92
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 3
choroid plexus 1
cerebrospinal fluid 1
microglia 1
hypothalamus 1
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Antihistamine 1 99.80 Very High Very High Very High
bradykinin 31 99.78 Very High Very High Very High
chemokine 18 99.52 Very High Very High Very High
opioid receptor 3 99.44 Very High Very High Very High
Central nervous system 393 99.08 Very High Very High Very High
Inflammation 66 97.96 Very High Very High Very High
ischemia 32 94.48 High High
Pain 8 93.52 High High
Hippocampus 36 93.20 High High
cva 12 90.08 High High
Disease Link Frequency Relevance Heat
Disease 154 100.00 Very High Very High Very High
Stress 34 100.00 Very High Very High Very High
Targeted Disruption 37 99.50 Very High Very High Very High
Necrosis 1 99.04 Very High Very High Very High
Cancer 166 98.64 Very High Very High Very High
Apoptosis 38 98.52 Very High Very High Very High
Hypoxia 9 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 258 98.32 Very High Very High Very High
Severe Combined Immunodeficiency 4 98.08 Very High Very High Very High
Viral Meningitis 36 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The V424I mutation localizes to the N-terminus of the ALMS1 protein while the H3882Y mutation localizes to the C-terminus of the protein [7].
Localization (localizes) of ALMS1
1) Confidence 0.70 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.49 Pain Relevance 0
However, the ALMS1 protein has been shown to be ubiquitously expressed and to localize subcellularly [9].
Localization (localize) of ALMS1
2) Confidence 0.70 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 1.57 Pain Relevance 0.04
The in vivo BBB permeation influx rate of [125I]TAPA after an i.v. bolus injection (7.3 pmol/g body weight) into mice was estimated to be 0.265 +/- 0.025 microL/(min.g of brain).
Localization (rate) of BBB in brain associated with body weight
3) Confidence 0.51 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12603838 Disease Relevance 0.10 Pain Relevance 0.12
A recent example of this is ghrelin, a substance produced by the stomach, which is transported across the BBB into the hypothalamus, where it induces hunger.
Localization (transported) of BBB in hypothalamus
4) Confidence 0.46 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.63 Pain Relevance 0.26
AD: Alzheimer's disease; BBB: blood-brain barrier; CNS: central nervous system; CSF: cerebrospinal fluid.


Localization (disease) of BBB in cerebrospinal fluid associated with central nervous system and disease
5) Confidence 0.46 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.87 Pain Relevance 0.20
In this paper, their permeability across the BBB
Localization (permeability) of BBB
6) Confidence 0.33 Published 2007 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2267214 Disease Relevance 0.90 Pain Relevance 0.26
This complex approach is known as molecular packaging strategy, where the peptide unit is part of a bulky molecule, dominated by groups that direct BBB penetration and prevent recognition by peptidases.
Localization (penetration) of BBB
7) Confidence 0.24 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0 Pain Relevance 0.13
For example, the extent of BBB equilibration for antihistamines and loperamide is low, thus decreasing their potential for central side effects versus peripheral effects.
Localization (equilibration) of BBB associated with antihistamine
8) Confidence 0.21 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.27
The physiochemical properties of the penetrating substance largely determine whether or not it can penetrate or be transported across the BBB.
Localization (transported) of BBB
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.05 Pain Relevance 0.04
The total brain exposure, and thus the pharmacological efficacy of a drug or drug candidate, depends on its drug uptake which in turn depends on a combination of factors, including the physical barrier presented by the BBB and the BCSF and the affinity of the substrate for specific transport systems located at both sides of these interfaces [26,27].
Localization (presented) of BBB in brain
10) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.59 Pain Relevance 0.19
The ability of a substance to penetrate the BBB or be transported across BBB is mainly dependent on its physiochemical properties.
Localization (penetrate) of BBB
11) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.74 Pain Relevance 0.22
A list of agents/condition and their effects on BBB are summarized in Table 1.
Localization (effects) of BBB
12) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.06 Pain Relevance 0
The ability of a substance to penetrate the BBB or be transported across BBB is mainly dependent on its physiochemical properties.
Localization (transported) of BBB
13) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.74 Pain Relevance 0.22
These Db:VP2121–130 epitope specific CD8 T cells then utilize perforin to deliver inflammatory components which ultimately result in activation of cellular components of the NVU, leading to rapid alteration of BBB tight junction proteins.
Localization (alteration) of BBB in T cells associated with inflammation
14) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.41 Pain Relevance 0.33
As quinacrine is known to be a substrate for P-glycoprotein multi-drug resistance (MDR) transporters, we circumvented its poor BBB permeability by utilizing MDR0/0 mice that are deficient in mdr1a and mdr1b genes.
Localization (permeability) of BBB
15) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2777304 Disease Relevance 0.17 Pain Relevance 0
Alternatively, emotions may render specific brain structures more vulnerable through increased secretion of stress hormones that breach the BBB in specific brain areas.
Localization (secretion) of BBB in brain associated with stress
16) Confidence 0.11 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.46 Pain Relevance 0.14
In addition, the preservation of BBB, the reduction in HIF-1?
Localization (preservation) of BBB
17) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.98 Pain Relevance 0.12
In a mouse model of HIVE based on animals with severe combined immunodeficiency (HIVE-SCID model), HIV-infected microglia and astrocytes seemed to regulate monocyte migration across the BBB via the release of ?
Localization (release) of BBB in microglia associated with acquired immune deficiency syndrome or hiv infection, severe combined immunodeficiency and viral meningitis
18) Confidence 0.09 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.62 Pain Relevance 0.26
As evidence that anti-INA Ab indeed penetrated the BBB and gained access to its cognate CNS targets, it was observed that there was IgG staining of the choroid plexus in INA+LPS treated mice (Figure 5A).
Localization (penetrated) of BBB in choroid plexus
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.45 Pain Relevance 0.12
When 5-HT released from these cells along with BK cross the BBB, the release of 5-HT at the axonal terminals in the serotonergic neurons in the brain will be inhibited, since the 5-HT1 autoreceptor have a higher affinity for 5-HT than do the 5-HT2 receptors.
Localization (release) of BBB in serotonergic neurons associated with bradykinin
20) Confidence 0.05 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15823715 Disease Relevance 1.03 Pain Relevance 0.40

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