INT108773

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.26
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
plasma 6
dendrites 2
brain 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 25 100.00 Very High Very High Very High
Eae 4 100.00 Very High Very High Very High
cINOD 40 99.98 Very High Very High Very High
diclofenac 2 96.16 Very High Very High Very High
aspirin 2 93.44 High High
Glutamate 4 79.68 Quite High
Inflammatory response 10 75.44 Quite High
Hippocampus 16 63.92 Quite High
Inflammation 56 56.84 Quite High
Central nervous system 20 43.44 Quite Low
Disease Link Frequency Relevance Heat
Generaliased Trisomy 5 99.44 Very High Very High Very High
Targeted Disruption 143 99.04 Very High Very High Very High
Syndrome 74 98.88 Very High Very High Very High
Disease 384 98.72 Very High Very High Very High
Repression 7 97.08 Very High Very High Very High
INFLAMMATION 84 96.40 Very High Very High Very High
Alzheimer's Dementia 120 92.32 High High
Death 27 92.12 High High
Apoptosis 36 89.16 High High
Cognitive Disorder 55 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presumably, the loss of FMRP/APP mRNA interaction results in rapid, pulsatile protein expression in dendrites.


Negative_regulation (loss) of APP mRNA Binding (interaction) of in dendrites
1) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.15 Pain Relevance 0
This strongly suggests a different composition of the vascular deposits in APP and TGF-?
Negative_regulation (deposits) of APP Binding (composition) of
2) Confidence 0.41 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.34 Pain Relevance 0.16
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Negative_regulation (inhibit) of APP Binding (interaction) of
3) Confidence 0.38 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Negative_regulation (inhibit) of APP Binding (interaction) of
4) Confidence 0.38 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
DownÂ’s syndrome (DS) patients, who are trisomic for chromosome 21 and thus have an extra copy of the APP gene, and FAD families with a duplicated APP gene locus [4] exhibit total A?
Negative_regulation (have) of APP gene Binding (copy) of associated with syndrome and generaliased trisomy
5) Confidence 0.38 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.41 Pain Relevance 0
Although the mechanisms by which these NSAIDs inhibit fA beta formation from A beta, and destabilize preformed fA beta in vitro are still unclear, NSAIDs may be promising for the prevention and treatment of AD.
Negative_regulation (inhibit) of fA beta Binding (formation) of associated with cinod and disease
6) Confidence 0.32 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16125740 Disease Relevance 0.72 Pain Relevance 0.82
These include inhibitors for Abeta-generating proteases, agents that prevent or reverse Abeta oligomerization, immunotherapies to reduce Abeta in brain and plasma, and drugs to modulate cholesterol-mediated effects on Abeta transport.
Negative_regulation (reverse) of Abeta Binding (oligomerization) of in plasma associated with eae and abeta
7) Confidence 0.30 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604663 Disease Relevance 0.93 Pain Relevance 0.42
These include inhibitors for Abeta-generating proteases, agents that prevent or reverse Abeta oligomerization, immunotherapies to reduce Abeta in brain and plasma, and drugs to modulate cholesterol-mediated effects on Abeta transport.
Negative_regulation (prevent) of Abeta Binding (oligomerization) of in plasma associated with eae and abeta
8) Confidence 0.30 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604663 Disease Relevance 0.93 Pain Relevance 0.42
These include inhibitors for Abeta-generating proteases, agents that prevent or reverse Abeta oligomerization, immunotherapies to reduce Abeta in brain and plasma, and drugs to modulate cholesterol-mediated effects on Abeta transport.
Negative_regulation (prevent) of Abeta in brain Binding (oligomerization) of in plasma associated with eae and abeta
9) Confidence 0.10 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604663 Disease Relevance 0.93 Pain Relevance 0.42
These include inhibitors for Abeta-generating proteases, agents that prevent or reverse Abeta oligomerization, immunotherapies to reduce Abeta in brain and plasma, and drugs to modulate cholesterol-mediated effects on Abeta transport.
Negative_regulation (reverse) of Abeta in brain Binding (oligomerization) of in plasma associated with eae and abeta
10) Confidence 0.10 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604663 Disease Relevance 0.93 Pain Relevance 0.42
Consequently, academic and pharmaceutical laboratories have focused on elucidating the mechanisms of Abeta production and developing strategies to diminish Abeta formation for treatment or prevention of AD.
Negative_regulation (diminish) of Abeta Binding (formation) of associated with disease and abeta
11) Confidence 0.08 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17105431 Disease Relevance 0.76 Pain Relevance 0.30

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