INT108780

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2011
Negated 0
Speculated 5
Reported most in Body
Documents 94
Total Number 99
Disease Relevance 59.71
Pain Relevance 16.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
macrophages 10
PGE2 6
lung 6
MDA-MB-468 5
hippocampus 4
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 211 100.00 Very High Very High Very High
COX2 102 100.00 Very High Very High Very High
qutenza 62 100.00 Very High Very High Very High
Inflammation 1139 99.98 Very High Very High Very High
cerebral cortex 15 99.84 Very High Very High Very High
Central nervous system 49 99.40 Very High Very High Very High
COX-2 inhibitor 144 99.28 Very High Very High Very High
rheumatoid arthritis 106 98.60 Very High Very High Very High
Hippocampus 18 98.60 Very High Very High Very High
cytokine 338 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hemophilus Infection 1246 100.00 Very High Very High Very High
Hyperalgesia 35 100.00 Very High Very High Very High
INFLAMMATION 1261 99.98 Very High Very High Very High
Cancer 1276 99.90 Very High Very High Very High
Malignant Neoplastic Disease 160 99.84 Very High Very High Very High
Meningitis 111 99.78 Very High Very High Very High
Targeted Disruption 312 99.70 Very High Very High Very High
Infection 774 99.64 Very High Very High Very High
Apoptosis 841 99.60 Very High Very High Very High
Sprains And Strains 295 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monkey oocyte responses to EP receptor agonists
Positive_regulation (responses) of Gene_expression (agonists) of EP receptor in oocyte associated with agonist
1) Confidence 0.49 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.22
Mouse oocyte responses to EP receptor agonists
Positive_regulation (responses) of Gene_expression (agonists) of EP receptor in Mouse associated with agonist
2) Confidence 0.49 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.14
In mice, the EP2 receptor has been reported to be highly expressed in cerebral cortex, striatum, and hippocampus [7,8].
Positive_regulation (highly) of Gene_expression (expressed) of EP2 receptor in hippocampus associated with hippocampus and cerebral cortex
3) Confidence 0.47 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.43 Pain Relevance 0.24
because of induction of PGE2 production, addition of KT5720 to H37Ra-infected M?
Positive_regulation (induction) of Gene_expression (production) of PGE2
4) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.60 Pain Relevance 0
VEGF increase due to EP2 and EP4 agonists
Positive_regulation (due) of Gene_expression (agonists) of EP2 associated with agonist
5) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.16 Pain Relevance 0.23
Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors.
Positive_regulation (capsaicin-induced) of Gene_expression (protection) of EP2 associated with qutenza
6) Confidence 0.39 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12604682 Disease Relevance 0 Pain Relevance 0.96
Western blot analysis (Fig. 1C) and immunofluorescence microscopy (Fig. 1D) confirmed elevated expression of EP2 receptor protein in the FPEP2 cells compared to the FPS32 cells while the FP receptor expression was not altered between the two cell lines.
Positive_regulation (elevated) of Gene_expression (expression) of EP2 receptor protein
7) Confidence 0.39 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
We initially confirmed that EP2 expression occurred in the cochlea and showed a similar pattern to EP4 expression [9].
Positive_regulation (occurred) of Gene_expression (expression) of EP2 in cochlea
8) Confidence 0.38 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.25 Pain Relevance 0.23
PGE2 is generated in most cells in response to mechanical, thermal or chemical injury and inflammatory insult, resulting in sensitization or direct activation of nearby sensory nerve endings.
Positive_regulation (generated) of Gene_expression (generated) of PGE2 in sensory nerve associated with inflammation and injury
9) Confidence 0.35 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 1.15 Pain Relevance 0.89
Numerous experimental models have convincingly demonstrated that the increased production of PGE2 in various tumours, including EOC, is involved in tumorigenesis [19].
Positive_regulation (increased) of Gene_expression (production) of PGE2 associated with cancer and ovarian cancer
10) Confidence 0.32 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.00 Pain Relevance 0.09
Therefore, it is important to regulate the production of PGE2 for the maintenance and successful accomplishment of function.
Positive_regulation (important) of Gene_expression (production) of PGE2
11) Confidence 0.30 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.05 Pain Relevance 0.09
infected with H37Rv could not be inhibited even by high concentrations of PGE2, indicating that EP2 is the major PGE2 receptor responsible for inhibition of mitochondrial cationic dye release.
Positive_regulation (concentrations) of Gene_expression (concentrations) of PGE2
12) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.05 Pain Relevance 0
In order to investigate prostanoid integrative signaling, we stably transfected the EP2 receptor into Ishikawa cells stably expressing the FP receptor.
Positive_regulation (transfected) of Gene_expression (transfected) of EP2
13) Confidence 0.28 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.14 Pain Relevance 0
In addition others have shown activation of the EP2 receptors can trigger the Wnt signaling pathway that involves phosphorylation of glycogen synthase kinase-3 (GSK-3) by Akt to activate ?
Positive_regulation (activation) of Gene_expression (receptors) of EP2
14) Confidence 0.28 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.41 Pain Relevance 0.12
by 5-LO gene silencing led to PGE2 production (Fig. 4 E).
Positive_regulation (led) of Gene_expression (production) of PGE2
15) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.83 Pain Relevance 0.08
Infection of macrophages with the avirulent H37Ra triggers production of high levels of the prostanoid PGE2, which promotes protection against mitochondrial inner membrane perturbation and necrosis.
Positive_regulation (levels) of Gene_expression (production) of PGE2 in macrophages associated with necrosis and infection
16) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2585850 Disease Relevance 1.47 Pain Relevance 0.05
Infection of macrophages with the avirulent H37Ra triggers production of high levels of the prostanoid PGE2, which promotes protection against mitochondrial inner membrane perturbation and necrosis.
Positive_regulation (triggers) of Gene_expression (production) of PGE2 in macrophages associated with necrosis and infection
17) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2585850 Disease Relevance 1.48 Pain Relevance 0.05
apoptosis is associated with increased PGE2 production.
Positive_regulation (increased) of Gene_expression (production) of PGE2 associated with apoptosis
18) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.29 Pain Relevance 0
The role of mPGES-1 for PGE2 production in these cells are essential since isolated peritoneal macrophages from mPGES-1 null mice produced minimal amounts of this prostanoids in response to pro-inflammatory stimuli (LPS) [50].
Positive_regulation (role) of Gene_expression (production) of PGE2 in peritoneal macrophages associated with inflammatory stimuli
19) Confidence 0.26 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.00 Pain Relevance 0.20
As shown in Fig. 1A, quantitative real-time RT-PCR revealed a significant increase of EP2 receptor expression above the parental FPS32 cells (P < 0.0001).
Positive_regulation (increase) of Gene_expression (expression) of EP2
20) Confidence 0.26 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0

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