INT10879

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Context Info
Confidence 0.65
First Reported 1985
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 14.01
Pain Relevance 8.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
plasma 3
uterine 3
hypothalamus 3
pituitary 3
hippocampal formation 1
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 134 99.98 Very High Very High Very High
anesthesia 12 99.98 Very High Very High Very High
fluoxetine 11 99.78 Very High Very High Very High
halothane 8 99.76 Very High Very High Very High
Hippocampus 36 99.40 Very High Very High Very High
tetrodotoxin 1 98.80 Very High Very High Very High
withdrawal 4 98.74 Very High Very High Very High
narcan 4 98.26 Very High Very High Very High
5HT 1 98.12 Very High Very High Very High
Enkephalin 8 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 535 100.00 Very High Very High Very High
Anxiety Disorder 144 99.60 Very High Very High Very High
Acidosis 2 98.92 Very High Very High Very High
Opiate Addiction 1 98.92 Very High Very High Very High
Neurodegenerative Disease 13 98.80 Very High Very High Very High
Targeted Disruption 246 98.28 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 222 97.96 Very High Very High Very High
Dysmenorrhea 8 97.72 Very High Very High Very High
Cyst 50 97.12 Very High Very High Very High
Amnesia 4 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, fluoxetine treatment increased PVN Avp mRNA levels in female Avpr1b wild type but not KO animals.
Positive_regulation (increased) of Avp mRNA in PVN associated with targeted disruption and fluoxetine
1) Confidence 0.65 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.58 Pain Relevance 0.94
We had previously found that chronic ethanol ingestion resulted in decreased levels of hypothalamic and extrahypothalamic vasopressin mRNA, and the current study investigated the effect of ethanol ingestion on prodynorphin mRNA levels.
Positive_regulation (resulted) of vasopressin
2) Confidence 0.55 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.09
Thus, amnesic model mice are deficient in brain AVP levels, and consequently, a certain level of AVP in the hypothalamus is required for maintaining the normal function such as the development of tolerance to morphine and the recovery from amnesia.
Positive_regulation (required) of AVP in hypothalamus associated with tolerance, amnesia and morphine
3) Confidence 0.50 Published 1993 Journal Brain Res. Section Abstract Doc Link 8508324 Disease Relevance 0.55 Pain Relevance 0.78
The fact that the NAB line's most common genotype for the Avp gene and surrounding sequence fully corresponds to the HAB-specific sequence helps to explain the often observed discrepancy between NAB and F1 mice, both of which are often used as controls.
Positive_regulation (genotype) of Avp associated with anxiety disorder
4) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.82 Pain Relevance 0.11
Collectively, these results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF(1) and V(1b) receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.
Positive_regulation (role) of AVP in hippocampal formation associated with antidepressant, antagonist and neurodegenerative disease
5) Confidence 0.49 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 1.11 Pain Relevance 0.41
Chronic stress from repeated (daily) exposure to an acute stressor leading to ACTH hyperresponsiveness to a single, novel stressor episode may also involve an increase in PVN Avp (Ma et al. 1999) and pituitary Avpr1b expression, and pituitary ACTH hyperresponsiveness (Aguilera 1994).
Positive_regulation (increase) of Avp in pituitary associated with stress
6) Confidence 0.48 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.72 Pain Relevance 0.08
Three analogues of posterior pituitary hormones, 1-deamino-2-D-Tyr(OEt)-4-Val-8-Orn-vasotocin(dE-VVT), 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin(dE-TVT) and 1-deamino-2-D-Tyr(OEt)-oxytocin(dE-OXY) were compared for their inhibitory effects on vasopressin (VP)-induced uterine activity in healthy women.
Positive_regulation (induced) of vasopressin in uterine
7) Confidence 0.46 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3942702 Disease Relevance 0.33 Pain Relevance 0.17
Three analogues of posterior pituitary hormones, 1-deamino-2-D-Tyr(OEt)-4-Val-8-Orn-vasotocin(dE-VVT), 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin(dE-TVT) and 1-deamino-2-D-Tyr(OEt)-oxytocin(dE-OXY) were compared for their inhibitory effects on vasopressin (VP)-induced uterine activity in healthy women.
Positive_regulation (induced) of VP in uterine
8) Confidence 0.46 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3942702 Disease Relevance 0.33 Pain Relevance 0.17
Corticotrophin-releasing factor (CRF) and vasopressin (AVP) are key regulators of the stress response via activation of CRF(1) and V(1b) receptors, respectively.
Positive_regulation (activation) of AVP associated with stress
9) Confidence 0.45 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 0.79 Pain Relevance 0.26
Corticotrophin-releasing factor (CRF) and vasopressin (AVP) are key regulators of the stress response via activation of CRF(1) and V(1b) receptors, respectively.
Positive_regulation (activation) of vasopressin associated with stress
10) Confidence 0.45 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 0.79 Pain Relevance 0.26
A study on the vasopressin induced delay in the gastrointestinal transit in mice: possible mechanism of action.
Positive_regulation (induced) of vasopressin
11) Confidence 0.44 Published 1993 Journal Life Sci. Section Title Doc Link 8103186 Disease Relevance 0 Pain Relevance 0.10
Oosterbaan and Swaab [3] also showed that while a rise in amniotic OT levels seems to reflect normal development of the human fetus, increased amniotic AVP levels may indicate fetal acidosis.
Positive_regulation (increased) of AVP associated with acidosis
12) Confidence 0.39 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.18 Pain Relevance 0.08
Based on current knowledge, these processes are receptor mediated, with a central role being ascribed to the activation of the OT/AVP and their receptor systems, particularly with regard to uterine contractions as well as decidual activation [31].
Positive_regulation (activation) of AVP in uterine associated with dismenorea
13) Confidence 0.34 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.19 Pain Relevance 0.10
Fibers projecting from SCN neurons that are immunoreactive for AVP and VIP exhibit a characteristic morphology, and project to the lateral septum, a series of medial hypothalamic areas extending from the preoptic to the posterior hypothalamic area and to the paraventricular thalamic nucleus.
Positive_regulation (immunoreactive) of AVP in paraventricular thalamic nucleus
14) Confidence 0.33 Published 2001 Journal Brain Res. Section Abstract Doc Link 11597605 Disease Relevance 0.08 Pain Relevance 0.27
Antibodies to 3'-5' AVP-binding peptide bound to cells, and the binding was inhibited by excess AVP.
Positive_regulation (excess) of AVP
15) Confidence 0.32 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.17
IR vasopressin content increased in hypothalamus and residual brain.
Positive_regulation (increased) of vasopressin in brain
16) Confidence 0.25 Published 1985 Journal Neurobiol. Aging Section Abstract Doc Link 3158833 Disease Relevance 0 Pain Relevance 0.45
Naloxone-precipitated withdrawal syndrome in the tolerant/dependent animals resulted in abrupt increases in the OXT and AVP levels of the hippocampus and in the OXT content of the basal forebrain structures.
Positive_regulation (increases) of AVP in hippocampus associated with narcan, hippocampus and withdrawal
17) Confidence 0.21 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 3556459 Disease Relevance 0.10 Pain Relevance 0.83
Arginine vasopressin (AVP) is a potent activator of renal adenyl cyclase [25].
Positive_regulation (activator) of AVP
18) Confidence 0.20 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.10 Pain Relevance 0.11
The study has revealed 3 types of reactions in hormones regulating water-electrolyte homeostasis: type I--a decrease in vasopressin (VP) concentration and renin-angiotensin-aldosterone system (RAAS) activity; type II--VP increase and RAAS activation; type III--an increase in VP content and RAAS disbalance.
Positive_regulation (activation) of VP
19) Confidence 0.18 Published 1992 Journal Anesteziol Reanimatol Section Abstract Doc Link 1524247 Disease Relevance 0.09 Pain Relevance 0.16
Our studies in Avpr1b KO mice (Lolait et al. 2007a,b; Stewart et al. 2008a,b) and similar studies on acute stress in Brattleboro rats (Domokos et al. 2008; Zelena et al. 2009) both often note a disparity between stress-induced ACTH versus CORT release in Avp/Avpr1b-deficient animals.
Positive_regulation (induced) of Avp associated with stress and targeted disruption
20) Confidence 0.17 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.93 Pain Relevance 0

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