INT108793

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 3.91
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PITX2) transcription factor binding (PITX2)
Anatomy Link Frequency
fat 1
brain 1
PITX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 62 99.20 Very High Very High Very High
drug abuse 1 99.20 Very High Very High Very High
member 8 1 99.02 Very High Very High Very High
opioid receptor 4 98.44 Very High Very High Very High
addiction 3 98.44 Very High Very High Very High
tolerance 10 95.68 Very High Very High Very High
Hyperalgesia 3 94.84 High High
cINOD 5 94.12 High High
Morphine 8 92.96 High High
Neuropathic pain 3 91.44 High High
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.20 Very High Very High Very High
Obesity 53 99.08 Very High Very High Very High
Apoptosis 17 98.24 Very High Very High Very High
Myopia 2 97.44 Very High Very High Very High
Hyperalgesia 3 94.84 High High
INFLAMMATION 22 93.60 High High
Disease 15 92.76 High High
Neuropathic Pain 3 91.44 High High
Cancer 50 90.48 High High
Diabetes Mellitus 46 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that RGS proteins endogenously expressed in C6 cells reduce agonist-induced mu-opioid receptor desensitization, down-regulation, and sensitivity to tolerance to inhibit adenylyl cyclase activity.
Gene_expression (expressed) of RGS associated with tolerance, agonist and opioid receptor
1) Confidence 0.75 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15383633 Disease Relevance 0.11 Pain Relevance 0.80
In turn, addictive drugs control the expression levels of several RGS proteins.
Gene_expression (expression) of RGS
2) Confidence 0.75 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20201861 Disease Relevance 0.09 Pain Relevance 0.26
Finally, we consider if RGS proteins represent viable targets for drug abuse medications.
Gene_expression (represent) of RGS associated with drug abuse
3) Confidence 0.65 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 15734717 Disease Relevance 0.10 Pain Relevance 0.21
We hypothesized that the up-regulated expression of one or more members of the regulator of G protein signaling (RGS) family can cause an attenuation of signaling via Gi/Go-coupled opioid receptors, and thereby play a role in the development of hyperalgesia and accompanying insensitivity to morphine observed in animal models of neuropathic pain.
Gene_expression (expression) of RGS associated with hyperalgesia, neuropathic pain, opioid receptor and morphine
4) Confidence 0.58 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604710 Disease Relevance 0.40 Pain Relevance 0.71
Among the RGS proteins expressed in the brain, RGS9-2 is very abundant in the striatum, a brain region involved in movement, motivation, mood and addiction.
Gene_expression (expressed) of RGS in brain associated with addiction
5) Confidence 0.58 Published 2009 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 19211160 Disease Relevance 0 Pain Relevance 0.16
We previously did not find any PITX2 nor FOXC1 mutation in these patients.
Spec (find) Gene_expression (mutation) of PITX2
6) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.63 Pain Relevance 0.05
Although further studies are needed to prove that an increased expression of Egr-1 by PTX-2 directly leads to NAG-1 induction and then apoptosis induction in p53-deficient Hep3B cells, the results of this study suggest that PTX-2 may be a good candidate for the development of a potential anti-tumorigenic agent in p53-deficient tumors.
Gene_expression (expression) of PTX-2 associated with cancer and apoptosis
7) Confidence 0.07 Published 2008 Journal Oncol. Rep. Section Abstract Doc Link 18202802 Disease Relevance 1.22 Pain Relevance 0.19
Only three RGS gene products were found at significantly high levels: Rgs14, Rgs20, and Snx13.
Gene_expression (products) of RGS
8) Confidence 0.05 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.06
Experimental manipulation of RGS protein expression can alter GPCR signaling, but the physiologic role of RGS proteins is unclear.
Gene_expression (expression) of RGS
9) Confidence 0.02 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.24 Pain Relevance 0.06
Their beta-arrestin, RGS protein, and GRK levels suggest the capacity to highly regulate GPCR signaling as well.
Gene_expression (levels) of RGS
10) Confidence 0.02 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.09 Pain Relevance 0.28
expression of RGS and CC3 was lower in these cells as
Gene_expression (expression) of RGS
11) Confidence 0.02 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
The SNPs rs689465, rs689466, rs20417 and rs5275, which showed a higher than 0.10 MAF in this first population subset, were selected for further characterization in a larger sample (Table 2).
Gene_expression (selected) of SNPs rs689465
12) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2992523 Disease Relevance 0.13 Pain Relevance 0
The SNPs rs689465, rs689466, rs20417 and rs5275 were selected for the case-control study and appear to be the most frequent SNPs in other Western populations [16,21,23,25,51-58].
Gene_expression (selected) of SNPs rs689465
13) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2992523 Disease Relevance 0.30 Pain Relevance 0
The variants selected were the potassium inwardly-rectifying channel J11 (KCNJ11) single nucleotide polymorphism (SNP) rs5219 (E23K variant); the peroxisome proliferator-activated receptor gamma (PPARG) SNP rs1801282 (Pro12Ala variant); the transcription factor 7-like 2 (TCF7L2) SNP rs7903146; the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) SNP rs4402960; the CDK5 regulatory subunit associated protein1-like 1 (CDKAL1) SNP rs10946398; the solute carrier family 30 (zinc transporter), member 8 (SLC30A8) SNP rs13266634; the hematopoietically expressed homeobox (HHEX) SNP rs1111875; and the fat mass and obesity associated (FTO) SNP rs9939609.
Gene_expression (expressed) of rs1111875 in fat associated with member 8 and obesity
14) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.58 Pain Relevance 0.10

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