INT108796

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 6.84
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR2) signal transduction (ESR2) mitochondrion (ESR2)
nucleus (ESR2) enzyme binding (ESR2) DNA binding (ESR2)
Anatomy Link Frequency
joint 3
molar 1
ESR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 39 100.00 Very High Very High Very High
Catecholamine 49 88.60 High High
agonist 84 44.88 Quite Low
noradrenaline 35 39.12 Quite Low
Clonidine 14 16.28 Low Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eating Disorder 35 99.92 Very High Very High Very High
Obesity 910 99.76 Very High Very High Very High
Endometriosis (extended) 14 99.38 Very High Very High Very High
Diabetes Mellitus 42 95.12 Very High Very High Very High
Toxicity 3 94.20 High High
Thinness 14 89.04 High High
Disorder Of Lipid Metabolism 35 67.12 Quite High
Metabolic Syndrome 7 62.68 Quite High
Body Weight 7 60.84 Quite High
Genetic Predisposition To Disease 7 8.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In future research, it will be important to investigate if there are interactions between ESR2 gene alleles and environmental factors such as food intake.


ESR2 Binding (interactions) of
1) Confidence 0.46 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.12 Pain Relevance 0.17
Two ESR2 SNPs, rs7154455 and rs3020450, displayed allelic association with obesity in the joint analysis of women and men, nominal P value 0.0003–0.01, Table 4.
ESR2 Binding (Two) of in joint associated with obesity
2) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.60 Pain Relevance 0
ESR2 rs928554 and rs4986938, but not rs1256049, have been associated with bulimic behavior [19] and rs1256049, but not rs4986938, with anorexia nervosa [20].
ESR2 Binding (associated) of associated with eating disorder
3) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.43 Pain Relevance 0
Two ESR2 SNPs, rs7154455 and rs3020450, displayed allelic association with obesity in the joint analysis of women and men, nominal P value 0.0003–0.01, Table 4.
ESR2 Binding (association) of in joint associated with obesity
4) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.67 Pain Relevance 0
For ESR2 SNPs rs1152582, rs1271572 and rs1269056, allelic associations with obesity were observed in women, nominal P value 0.03–0.05, but not in joint analysis of women and men, Table 4.
ESR2 Binding (associations) of in joint associated with obesity
5) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.91 Pain Relevance 0
This suggests that the allelic association of the two ESR2 SNPs in sample 1 was spurious.
ESR2 Binding (association) of
6) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.02 Pain Relevance 0
In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity.
ESR2 Binding (association) of associated with obesity
7) Confidence 0.35 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2238734 Disease Relevance 0.54 Pain Relevance 0
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
ER beta Binding (presence) of
8) Confidence 0.31 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0
Specifically, the extent to which acetaminophen altered the expression of estrogen-inducible alkaline phosphatase in endometrial adenocarcinoma (Ishikawa) cells and directly interacted with ERbeta and ERalpha was determined.
ERbeta Binding (interacted) of associated with paracetamol and endometriosis (extended)
9) Confidence 0.27 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.17 Pain Relevance 0.56
These studies indicate acetaminophen exerts weak antiestrogenic activity in Ishikawa cells without directly binding ERalpha or ERbeta.
ERbeta Binding (binding) of associated with paracetamol
10) Confidence 0.27 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.16 Pain Relevance 0.75
Competition binding assays with human ERalpha and ERbeta demonstrated 10(6)-fold molar excess acetaminophen did not directly interact significantly with the ligand-binding domain of either receptor.
ERbeta Neg (not) Binding (interact) of in molar associated with paracetamol
11) Confidence 0.20 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.22 Pain Relevance 0.88

General Comments

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