INT108798

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.26
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
chondrocytes 4
Blood 2
body 2
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.98 Very High Very High Very High
antagonist 4 99.66 Very High Very High Very High
Osteoarthritis 82 92.52 High High
Pain 42 86.04 High High
sNRI 13 85.20 High High
Duloxetine 12 78.40 Quite High
fibrosis 1 75.60 Quite High
Paresthesia 1 64.60 Quite High
Inflammatory response 6 59.04 Quite High
Arthritis 10 50.36 Quite High
Disease Link Frequency Relevance Heat
Osteoarthropathy 17 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 6 99.52 Very High Very High Very High
Body Weight 34 98.96 Very High Very High Very High
Periostitis 1 98.72 Very High Very High Very High
Lung Cancer 4 92.56 High High
Osteoarthritis 82 92.52 High High
Vomiting 10 90.12 High High
Endometriosis (extended) 6 88.96 High High
Hepatotoxicity 14 86.88 High High
Poisoning 9 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen inhibited both basal and estradiol-induced alkaline phosphatase activity in Ishikawa cells in a concentration-dependent manner.
Negative_regulation (inhibited) of Positive_regulation (induced) of alkaline phosphatase associated with paracetamol
1) Confidence 0.25 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.16 Pain Relevance 0.74
Treatment of PBMCs with IL-2 and their subsequent co-culture with hMSCs lysed the cells and prevented induction of ALP, therefore, no or very low detection of ALP could be observed (Figs. 5A and 5B).
Negative_regulation (prevented) of Positive_regulation (induction) of ALP
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.07 Pain Relevance 0
Laboratory tests showed decrease in bilirubin levels, and increase in GGT, ALP, AST, ALT, total cholesterol, HDL, LDL, and triglycerides, demonstrating potential effects on the metabolic system.
Negative_regulation (decrease) of Positive_regulation (increase) of ALP associated with disorder of lipid metabolism
3) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695227 Disease Relevance 0.42 Pain Relevance 0.11
Blood studies are usually unaffected by HOA except that often an elevated ESR of more than 50 mm/h is seen and in advanced cases an elevated alkaline phosphatase level can be found [6].
Neg (unaffected) Negative_regulation (unaffected) of Neg (except) Positive_regulation (elevated) of alkaline phosphatase in Blood associated with osteoarthropathy
4) Confidence 0.08 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2323011 Disease Relevance 1.74 Pain Relevance 0.18
They also demonstrated that cycloheximide, a well known protein synthesis inhibitor, prevented the quercetin-induced ALP activation, indicating that de novo protein synthesis is essential for this response.
Negative_regulation (prevented) of Positive_regulation (activation) of ALP
5) Confidence 0.07 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2685048 Disease Relevance 0.11 Pain Relevance 0.07
The fact that ICI 182780, an antagonist of the ER, also prevents the quercetin-induced increase in ALP activity, indicates that this receptor is directly involved in the effect of quercetin.
Negative_regulation (prevents) of Positive_regulation (increase) of ALP associated with antagonist
6) Confidence 0.04 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2685048 Disease Relevance 0.21 Pain Relevance 0.05
Similarly post-treatment with taurine at a dose of 50 mg/kg body weight daily for 2 weeks after NaAsO2 administration also decreased the elevated level of ALP (figure 1C).
Negative_regulation (decreased) of Positive_regulation (elevated) of ALP in body associated with body weight
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.80 Pain Relevance 0
Conversely, incubation with NOS inhibitors reversed the increase in alkaline phosphatase activity, whereas cGMP inhibitors reversed the increases in alkaline phosphatase activity and collagen expression, demonstrating that NO helps to mediate the terminal differentiation of chondrocytes.
Negative_regulation (reversed) of Positive_regulation (increase) of alkaline phosphatase in chondrocytes
8) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.36 Pain Relevance 0.15
Conversely, incubation with NOS inhibitors reversed the increase in alkaline phosphatase activity, whereas cGMP inhibitors reversed the increases in alkaline phosphatase activity and collagen expression, demonstrating that NO helps to mediate the terminal differentiation of chondrocytes.
Negative_regulation (reversed) of Positive_regulation (increases) of alkaline phosphatase in chondrocytes
9) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.39 Pain Relevance 0.17

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