INT108799

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.98
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 2
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.98 Very High Very High Very High
metalloproteinase 15 96.80 Very High Very High Very High
Inflammation 11 61.04 Quite High
imagery 17 11.36 Low Low
Osteoarthritis 30 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 2 99.84 Very High Very High Very High
Seminoma 30 99.12 Very High Very High Very High
Ovarian Cancer 25 96.64 Very High Very High Very High
Cancer 117 96.24 Very High Very High Very High
Testicular Cancer 10 92.08 High High
Osteoarthritis 33 90.76 High High
Pressure And Volume Under Development 11 88.20 High High
Immunization 15 86.64 High High
Carcinoma 5 84.76 Quite High
Embryonal Carcinoma 35 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum concentrations of PLAP and PLAP-like enzymes were
Regulation (concentrations) of Gene_expression (enzymes) of PLAP
1) Confidence 0.27 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.28 Pain Relevance 0
Polyclonal antibodies against PLAP and PLAP-like enzymes may
Regulation (antibodies) of Gene_expression (enzymes) of PLAP
2) Confidence 0.27 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.68 Pain Relevance 0
samples, ICA-PLAP would reveal other PLAP/PLAP-like phenotypes in
Regulation (reveal) of Gene_expression (phenotypes) of PLAP
3) Confidence 0.27 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0 Pain Relevance 0
Specifically, the extent to which acetaminophen altered the expression of estrogen-inducible alkaline phosphatase in endometrial adenocarcinoma (Ishikawa) cells and directly interacted with ERbeta and ERalpha was determined.
Regulation (altered) of Gene_expression (expression) of alkaline phosphatase associated with paracetamol and endometriosis (extended)
4) Confidence 0.27 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12604834 Disease Relevance 0.17 Pain Relevance 0.54
Exposure to 1 µM and 10 µM pinacidil resulted in a 1.8-fold and 2.2-fold increase in BSP expression, respectively (Fig. 10B, p<0.04), but no significant change in ALP expression.
Neg (no) Regulation (change) of Gene_expression (expression) of ALP
5) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
the presence of hPLAP (1 mg/mL), and the results were positive
Regulation (positive) of Gene_expression (presence) of hPLAP
6) Confidence 0.23 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.09 Pain Relevance 0
week of gestation had hPLAP activities that ranged from
Regulation (ranged) of Gene_expression (activities) of hPLAP
7) Confidence 0.23 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.16 Pain Relevance 0
There were significant differences in changes in urinary NTX and CTX levels and serum bone-specific ALP levels, but not in those in serum NTX levels, between the 2 groups (two-way ANOVA with repeated measurements, Table 2).
Regulation (changes) of Neg (not) Gene_expression (levels) of ALP
8) Confidence 0.07 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703758 Disease Relevance 0.15 Pain Relevance 0
Experiments performed with osteoblasts showed a weak but bipolar effect on alkaline phosphatase expression: stimulation at 1 ?
Regulation (effect) of Gene_expression (expression) of alkaline phosphatase in osteoblasts
9) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

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