INT1088

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Context Info
Confidence 0.40
First Reported 1976
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.65
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) plasma membrane (Msr1)
Anatomy Link Frequency
dorsal root 2
posterior 2
semitendinosus 2
Msr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 4 99.52 Very High Very High Very High
narcan 2 99.48 Very High Very High Very High
fluoxetine 5 99.36 Very High Very High Very High
antagonist 6 99.24 Very High Very High Very High
Clonidine 2 98.80 Very High Very High Very High
Pain 4 98.40 Very High Very High Very High
withdrawal 1 80.88 Quite High
Spinal cord 7 79.20 Quite High
Painful diabetic neuropathy 1 75.00 Quite High
monoamine 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 5 99.12 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 1 98.40 Very High Very High Very High
Diabetic Neuropathy 1 75.00 Quite High
Neuropathy 1 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the MSR and PSR was not reduced by 1 microM naloxone, 1 microM strychnine, 1 microM bicuculline nor 10-30 microM APV.
Neg (not) Negative_regulation (reduced) of Negative_regulation (Inhibition) of MSR associated with narcan
1) Confidence 0.40 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.23
Fluoxetine HCl (Lilly 110140, 0.25 - 6 mg/kg), a specific serotonin neuronal uptake blocker, also blocked this inhibition as well as bulbospinal inhibition of the flexor posterior biceps-semi-tendinosus MSR.
Negative_regulation (blocked) of Negative_regulation (inhibition) of MSR in posterior associated with serotonin and fluoxetine
2) Confidence 0.32 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086122 Disease Relevance 0 Pain Relevance 0.49
Inhibition of the MSR from 2-50 sec was greatly reduced by 5-HT2 receptor antagonists.
Negative_regulation (reduced) of Negative_regulation (Inhibition) of MSR associated with antagonist
3) Confidence 0.26 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8429918 Disease Relevance 0 Pain Relevance 0.18
Presynaptic inhibition of the flexor (posterior biceps-semitendinosus, PBST) MSR was however not blocked by imipramine, fluoxetine or a cold block nor enhanced by cyproheptadine or phenoxybenzamine.
Negative_regulation (blocked) of Negative_regulation (inhibition) of MSR in semitendinosus associated with fluoxetine
4) Confidence 0.23 Published 1977 Journal Brain Res. Section Abstract Doc Link 139193 Disease Relevance 0 Pain Relevance 0.39
By contrast, the presynaptic inhibition of the MSR and DSR elicited by preceding conditioning stimulation to the ipsilateral L4 dorsal root was not impaired.
Negative_regulation (impaired) of Negative_regulation (inhibition) of MSR in dorsal root
5) Confidence 0.23 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16102902 Disease Relevance 0.65 Pain Relevance 0.34

General Comments

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